- Synthesis of All Possible A-ring Diastereomers at the 1-and 3-Positions of 1 alpha,25-Dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3 (ED-71) Using C-2-Symmetrical Epoxide as a Common Starting Material
[作者:Kubodera, N; Hatakeyama, S,期刊:Anticancer Research, 页码:3571-3578 , 文章类型: Article,,卷期:2009年29-9]
- The active vitamin D-3, 1a,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), is now well recognized as a potent regulator of cell proliferation and differentiation in addition to possessing a regulatory effect on calcium and pho...
- Antiproliferative and Calcemic Actions of Trans-Decalin CD-Ring Analogs of 1,25-Dihydroxyvitamin D-3
[作者:Eelen, G; Verlinden, L; Laureys, J; Marcelis, S; De Clercq, P; Mathieu, C; Bouillon, R; Verstuyf, A,期刊:Anticancer Research, 页码:3579-3584 , 文章类型: Article,,卷期:2009年29-9]
- Background: 1,25-Dihydroxyvitamin D-3 [1,25(OH)(2)D-3] has potent antiproliferative actions but calcemic effects obstruct its application in the treatment of hyperproliferative disorders. Therefore, analogs of 1,25(OH)(2...
- Microarray Analysis of MCF-7 Breast Cancer Cells Treated with 1,25-Dihydroxyvitamin D-3 or a 17-Methyl-D-ring Analog
[作者:Vanoirbeek, E; Eelen, G; Verlinden, L; Marchal, K; Engelen, K; De Moor, B; Beullens, I; Marcelis, S; De Clercq, P; Bouillon, R; Verstuyf, A,期刊:Anticancer Research, 页码:3585-3590 , 文章类型: Article,,卷期:2009年29-9]
- Background: 1 alpha,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] is the biological active form of vitamin D. Its antiproliferative capacities make it a potential drug to treat diseases such as cancer. The clinical use of 1,...
- Fish Oil Enhances the Antiproliferative Effect of 1 alpha,25-Dihydroxyvitamin D-3 on Liver Cancer Cells
[作者:Chiang, KC; Persons, KS; Istfan, NW; Holick, MF; Chen, TC,期刊:Anticancer Research, 页码:3591-3596 , 文章类型: Article,,卷期:2009年29-9]
- Background: Laboratory and epidemiological studies have indicated that la,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3] and dietary omega 3 (omega 3)-polyunsaturated fatty acids (PUFAs) are capable of inhibiting the pro...
- Expression of Prostaglandin Metabolising Enzymes COX-2 and 15-PGDH and VDR in Human Granulosa Cells
[作者:Thill, M; Becker, S; Fischer, D; Cordes, T; Hornemann, A; Diedrich, K; Salehn, D; Friedrich, M,期刊:Anticancer Research, 页码:3611-3618 , 文章类型: Article,,卷期:2009年29-9]
- Background: Prostaglandins (PGs) within the periovulatory follicle are essential for various female reproductive functions such as follicular development and maturation. In animal models, granulosa cells express the PG s...
- Prostaglandin Metabolizing Enzymes in Correlation with Vitamin D Receptor in Benign and Malignant Breast Cell Lines
[作者:Thill, M; Fischer, D; Becker, S; Cordes, T; Dittmer, C; Diedrich, K; Salehin, D; Friedrich, M,期刊:Anticancer Research, 页码:3619-3625 , 文章类型: Article,,卷期:2009年29-9]
- Background: The antiproliferative effects of calcitriol (1,25(OH)(2)D-3) mediated via the vitamin D receptor (VDR), render the biologically active form of vitamin D a promising target in breast cancer therapy. Furthermor...
- 25-Hydroxyvitamin D-3 1 alpha-Hydroxylase Splice Variants in Benign and Malignant Ovarian Cell Lines and Tissue
[作者:Fischer, D; Thome, M; Becker, S; Cordes, T; Diedrich, K; Friedrich, M; Thill, M,期刊:Anticancer Research, 页码:3627-3633 , 文章类型: Article,,卷期:2009年29-9]
- Calcitriol is judged to have a positive effect on control of the immune system, cell growth and differentiation and therefore, the prevention of cancer genesis. The aim of this study was to detect any possible difference...
- Expression of 25-Hydroxyvitamin D-3-24-Hydroxylase in Benign and Malignant Ovarian Cell Lines and Tissue
[作者:Fischer, D; Thome, M; Becker, S; Cordes, T; Diedrich, K; Friedrich, M; Thill, M,期刊:Anticancer Research, 页码:3635-3639 , 文章类型: Article,,卷期:2009年29-9]
- Calcitriol (1,25-dihydroxyvitamin D-3, 1,25(OH)(2)D-3) plays a pivotal role in maintaining calcium and phosphate homeostasis. Aside from that, it supports the native and attenuates the acquired immune system and has posi...
- Vitamin D-24-Hydroxylase in Benign and Malignant Breast Tissue and Cell Lines
[作者:Fischer, D; Becker, S; Cordes, T; Bucker, B; Diedrich, K; Friedrich, M; Salehin, D; Thill, M,期刊:Anticancer Research, 页码:3641-3645 , 文章类型: Article,,卷期:2009年29-9]
- Tissue-specific expression of 25-hydroxyvitamin D1 alpha-hydroxylase (1 alpha-OHase) and vitamin D-hydroxylase (24-OHase) may act as the pivotal link between 25-hydroxyvitamin D-3 (25(OH)D-3) serum levels and the antican...
- Cross-talk between Vitamin D Receptor (VDR)- and Peroxisome Proliferator-activated Receptor (PPAR)-signaling in Melanoma Cells
[作者:Sertznig, P; Dunlop, T; Seifert, M; Tilgen, W; Reichrath, J,期刊:Anticancer Research, 页码:3647-3658 , 文章类型: Article,,卷期:2009年29-9]
- The expression and signaling of the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor (PPAR) alpha, delta, gamma was investigated in the melanoma cell line MeWo. Using real-time PCR, the mRNA of the...
- Expression of 25-Hydroxyvitamin D-1 alpha-Hydroxylase (1 alpha OHase, CYP27B1) Splice Variants in HaCaT Keratinocytes and Other Skin Cells: Modulation by Culture Conditions and UV-B Treatment In Vitro
[作者:Seifert, M; Tilgen, W; Reichrath, J,期刊:Anticancer Research, 页码:3659-3667 , 文章类型: Article,,卷期:2009年29-9]
- In vitro and in vivo studies have demonstrated that the biologically active vitamin D metabolite 1,25-dihydroxyvitamin D (1,25(OH)(2)D-3, calcitriol) suppresses proliferation and induces differentiation in various cell t...
- Reduced Serum 25-Hydroxyvitamin D Levels in Stage IV Melanoma Patients
[作者:Nurnberg, B; Graber, S; Gartner, B; Geisel, J; Pfohler, C; Schadendorf, D; Tilgen, W; Reichrath, J,期刊:Anticancer Research, 页码:3669-3674 , 文章类型: Article,,卷期:2009年29-9]
- Background: Reduced serum 25-hydroxyvitamin D-3 (25(OH)D) levels are associated with an increased incidence and an unfavorable outcome of various types of cancer. However, the influence of serum 25(OH)D on the incidence ...
- Calcium, Vitamin D and Cancer
[作者:Peterlik, M; Grant, WB; Cross, HS,期刊:Anticancer Research, 页码:3687-3698 , 文章类型: Article,,卷期:2009年29-9]
- A low vitamin D status and inadequate calcium intake are important risk factors for various types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D-3 photoproduction in the skin found a hig...
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