- SIRT1: new avenues of discovery for disorders of oxidative stress
[作者:Chong, ZZ; Shang, YC; Wang, SH; Maiese, K,期刊:Expert Opinion on Therapeutic Targets, 页码:167-178 , 文章类型: Review,,卷期:2012年16-2]
- Introduction: The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxi...
- Pathophysiologic therapeutic targets in hypertension: a cardiological point of view
[作者:Fragasso, G; Maranta, F; Montanaro, C; Salerno, A; Torlasco, C; Margonato, A,期刊:Expert Opinion on Therapeutic Targets, 页码:179-193 , 文章类型: Review,,卷期:2012年16-2]
- Introduction: Treatment of arterial hypertension can be a difficult exercise. Anti-hypertensive treatments need to be administered, keeping in mind the pathophysiological mechanisms and correlates at the base of arterial...
- COX inhibitors for airway inflammation
[作者:Malhotra, S; Deshmukh, SS; Dastidar, SG,期刊:Expert Opinion on Therapeutic Targets, 页码:195-207 , 文章类型: Review,,卷期:2012年16-2]
- Introduction: The cyclooxygenase (COX) enzyme, which is responsible for the production of prostaglandins (PGs), key mediators of inflammation, may have the potential to become an attractive target for anti-inflammatory t...
- Targeting PPAR beta/delta for the treatment of type 2 diabetes mellitus
[作者:Salvado, L; Serrano-Marco, L; Barroso, E; Palomer, X; Vazquez-Carrera, M,期刊:Expert Opinion on Therapeutic Targets, 页码:209-223 , 文章类型: Review,,卷期:2012年16-2]
- Introduction: The nuclear receptors Peroxisome Proliferator-Activated Receptors (PPAR)alpha and PPAR gamma are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively. Evidence is now emerging t...
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