- Targeting of an Interrupted Polypurine:Polypyrimidine Sequence in Mammalian Cells by a Triplex-Forming Oligonucleotide Containing a Novel Base Analogue
[作者:Semenyuk, A; Darian, E; Liu, J; Majumdar, A; Cuenoud, B; Miller, PS; MacKerell, AD; Seidman, MM,期刊:Biochemistry, 页码:7867-7878 , 文章类型: Article,,卷期:2010年49-36]
- The DNA triple helix consists of a third strand of nucleic acid lying in the major groove of an intact DNA duplex. The most stable triplexes form on polypurine:polypyrimidine sequences, and pyrimidine interruptions in th...
- Mechanism of Potentiation of a Dysfunctional Epilepsy-Linked Mutated GABA(A) Receptor by a Neurosteroid (3 alpha, 21-Dihydroxy-5 alpha-pregnan-20-one): Transient Kinetic Investigations
[作者:Ramakrishnan, L; Hess, GP,期刊:Biochemistry, 页码:7892-7901 , 文章类型: Article,,卷期:2010年49-36]
- The malfunction of a mutated GABA(A) receptor (alpha 1 beta 2 gamma 2L(K289M)) in an inheritable form of epilepsy (GEES+, generalized epilepsy with febrile seizures plus) in humans [Baulac, S., Huberfeld, G., Gourfinkel-...
- Cell-Selective Lysis by Novel Analogues of Melittin against Human Red Blood Cells and Escherichia coli
[作者:Pandey, BK; Ahmad, A; Asthana, N; Azmi, S; Srivastava, RM; Srivastava, S; Verma, R; Vishwakarma, AL; Ghosh, JK,期刊:Biochemistry, 页码:7920-7929 , 文章类型: Article,,卷期:2010年49-36]
- Melittin is a good model antimicrobial peptide to understand the basis of its lytic activities against bacteria and mammalian cells. Novel analogues of melittin were designed by substituting the leucine residue(s) at the...
- Structural and Functional Studies of WlbA: A Dehydrogenase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-D-mannuronic Acid
[作者:Thoden, JB; Holden, HM,期刊:Biochemistry, 页码:7939-7948 , 文章类型: Article,,卷期:2010年49-36]
2,3-Diacetamido-2,3-dideoxy-D-mannuronic acid (ManNAc3NAcA) is an unusual dideoxy sugar first identified nearly 30 years ago in the lipopolysaccharide of Pseudomonas aeruginosa O:3a,d. It has since been observed in ot...
- Recombinant Expression, in Vitro Refolding, and Biophysical Characterization of the Human Glucagon-like Peptide-1 Receptor
[作者:Schroder-Tittmann, K; Bosse-Doenecke, E; Reedtz-Runge, S; Ihling, C; Sinz, A; Tittmann, K; Rudolph, R,期刊:Biochemistry, 页码:7956-7965 , 文章类型: Article,,卷期:2010年49-36]
- Activation of the glucagon-like peptide-1 receptor (GLP-1R) upon ligand binding leads to the release of insulin from pancreatic cells. This strictly glucose-dependent process renders the receptor and its ligands useful i...
- Selection for Nonamyloidogenic Mutants of Islet Amyloid Polypeptide (IAPP) Identifies an Extended Region for Amyloidogenicity
[作者:Fox, A; Snollaerts, T; Casanova, CE; Calciano, A; Nogaj, LA; Moffet, DA,期刊:Biochemistry, 页码:7783-7789 , 文章类型: Article,,卷期:2010年49-36]
- The aggregation of the 37-residue protein, islet amyloid polypeptide (IAPP), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic beta-islet cells in type II diabete...
- Structural and Functional Characterization of the Ga-Substituted Ferredoxin from Synechocystis sp PCC6803, a Mimic of the Native Protein
[作者:Xu, XF; Scanu, S; Chung, JS; Hirasawa, M; Knaff, DB; Ubbink, M,期刊:Biochemistry, 页码:7790-7797 , 文章类型: Article,,卷期:2010年49-36]
- In photosynthetic organisms, ferredoxin (Fd) interacts with many proteins, acting as a shuttle for electrons from Photosystem I to a group of enzymes involved in NADP(+) reduction, sulfur and nitrogen assimilation, and t...
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