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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共26条记录   Peptidic Targeting of Phosphatidylserine for the MRI Detection of Apoptosis in Atherosclerotic Plaques [作者：Burtea, C; Laurent, S; Lancelot, E; Ballet, S; Murariu, O; Rousseaux, O; Port, M; Elst, LV; Corot, C; Muller, RN,期刊：Molecular Pharmaceutics, 页码：1903-1919 , 文章类型： Article，,卷期：2009年6-6] Molecular and cellular imaging of atherosclerosis has garnered more interest at the beginning of the 21st century, with aims to image in vivo biological properties of plaque lesions. Apoptosis seems an attractive target ... Classification of Cytochrome P-450 Activities Using Machine Learning Methods [作者：Hammann, F; Gutmann, H; Baumann, U; Helma, C; Drewe, J,期刊：Molecular Pharmaceutics, 页码：1920-1926 , 文章类型： Article，,卷期：2009年6-6] The cytochrome P-450 (GYP) system plays an integral part in the metabolism of drugs and other xenobiotics. Knowledge of the structural features required for interaction with any of the different isoforms of the CYP syste... Self-Assembled Micronanoplexes for Improved Biolistic Delivery of Nucleic Acids [作者：Svarovsky, SA; Gonzalez-Moa, MJ; Robida, MD; Borovkov, AY; Sykes, K,期刊：Molecular Pharmaceutics, 页码：1927-1933 , 文章类型： Article，,卷期：2009年6-6] A new method for biolistic delivery of nucleic acids using a combination of cationic micro- and nanoparticles is reported. The new method is simpler to perform than the conventional calcium/spermidine-based formulations ... Regulating Immune Response Using Polyvalent Nucleic Acid-Gold Nanoparticle Conjugates [作者：Massich, MD; Giljohann, DA; Seferos, DS; Ludlow, LE; Horvath, CM; Mirkin, CA,期刊：Molecular Pharmaceutics, 页码：1934-1940 , 文章类型： Article，,卷期：2009年6-6] The immune response of macrophage cells to internalized polyvalent nucleic acid-functionalized gold nanoparticles has been studied. This study finds that the innate immune response (as measured by interferon-beta levels)... The Drug Transporter-Metabolism Alliance: Uncovering and Defining the Interplay [作者：Benet, LZ,期刊：Molecular Pharmaceutics, 页码：1631-1643 , 文章类型： Review，,卷期：2009年6-6] Two decades ago the importance of transporter-enzyme interplay and its effects on drug bioavailability and hepatic disposition were first recognized. Here we review the history of uncovering and defining this interplay w... Hepatic OATP1B Transporters and Nuclear Receptors PXR and CAR: Interplay, Regulation of Drug Disposition Genes, and Single Nucleotide Polymorphisms [作者：Schwabedissen, HEMZ; Kim, RB,期刊：Molecular Pharmaceutics, 页码：1644-1661 , 文章类型： Review，,卷期：2009年6-6] Drug uptake transporters are now increasingly recognized as clinically relevant determinants of variable drug responsiveness and unexpected drug-drug interactions. Emerging evidence strongly suggests members of the organ... Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug-Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry [作者：Soars, MG; Webborn, PJH; Riley, RJ,期刊：Molecular Pharmaceutics, 页码：1662-1677 , 文章类型： Review，,卷期：2009年6-6] The ability to predict hepatic metabolic clearance is a key component in the design and selection of small molecule drug candidates within the pharmaceutical industry. The recognition that metabolism-transporter interpla... Interplay of Transporters and Enzymes in Drug and Metabolite Processing [作者：Pang, KS; Maeng, HJ; Fan, JH,期刊：Molecular Pharmaceutics, 页码：1734-1755 , 文章类型： Review，,卷期：2009年6-6] This review highlights the "interplay" between enzymes and transporters, essential components of eliminating organs for drug removal. The understanding of the interplay is important in terms of deciphering the change of ... Scientific and Regulatory Perspectives on Metabolizing Enzyme-Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions [作者：Zhang, L; Zhang, YC; Huang, SM,期刊：Molecular Pharmaceutics, 页码：1766-1774 , 文章类型： Review，,卷期：2009年6-6] Both metabolizing enzymes and drug transporters play important roles in modulating drug absorption, distribution, metabolism and elimination. Acting alone or in concert with each other they can affect the pharmacokinetic... The Multifaceted Photocytotoxic Profile of Hypericin [作者：Theodossiou, TA; Hothersall, JS; De Witte, PA; Pantos, A; Agostinis, P,期刊：Molecular Pharmaceutics, 页码：1775-1789 , 文章类型： Review，,卷期：2009年6-6] Photodynamic therapy (PDT) is an established anticancer treatment employing a phototoxin (photosensitizer), visible light and oxygen. The latter is photochemically converted into reactive oxygen species, which are highly... Transport-Metabolism Interplay: LXR alpha-Mediated Induction of Human ABC Transporter ABCC2 (cMOAT/MRP2) in HepG2 Cells [作者：Adachi, T; Nakagawa, H; Hagiya, Y; Yasuoka, T; Ishikawa, T,期刊：Molecular Pharmaceutics, 页码：1678-1688 , 文章类型： Article，,卷期：2009年6-6] Human ATP-binding cassette (ABC) transporter ABCC2 (cMOAT/MRP2) plays a crucial role in the hepatobiliary transport of sulfate-, glucuronide-, and glutathione-conjugated metabolites as well as a variety of amphiphilic or... Formation and Efflux of ATP-Binding Cassette Transporter Substrate 2,4-Dinitrophenyl-S-Glutathione from Cultured Human Term Placental Villous Tissue Fragments [作者：Vaidya, SS; Walsh, SW; Gerk, PM,期刊：Molecular Pharmaceutics, 页码：1689-1702 , 文章类型： Article，,卷期：2009年6-6] Upon exposure to 1-chloro-2,4-dinitrobenzene (CDNB), the human placental tissue forms its glutathione conjugate 2,4-dinitrophenyl-S-glutathione (DNP-SG). The purpose of this study was to investigate the involvement of hu... Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides [作者：Xu, HY; Kulkarni, KH; Singh, R; Yang, Z; Wang, SWJ; Tam, VH; Hu, M,期刊：Molecular Pharmaceutics, 页码：1703-1715 , 文章类型： Article，,卷期：2009年6-6] The purposes of this study were to investigate how efflux transporters and UDP-glucuronosyltransferases (UGT) affect the disposition of naringenin. A rat intestinal perfusion model with bile duct cannulation was used alo... Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine [作者：Poirier, A; Funk, C; Scherrmann, JM; Lave, T,期刊：Molecular Pharmaceutics, 页码：1716-1733 , 文章类型： Article，,卷期：2009年6-6] A mechanistic model was applied to quantitatively derive the kinetic parameters from in vitro hepatic uptake transport data. These parameters were used as input to simulate in vivo elimination using a fully mechanistic p... Interplay of Drug Metabolism and Transport: A Real Phenomenon or an Artifact of the Site of Measurement? [作者：Endres, CJ; Endres, MG; Unadkat, JD,期刊：Molecular Pharmaceutics, 页码：1756-1765 , 文章类型： Article，,卷期：2009年6-6] The interdependence of both transport and metabolism on the disposition of drugs has recently gained heightened attention in the literature, and has been termed the "interplay of transport and metabolism". Such "interpla... Identification, Expression, and Functional Characterization of Full-Length and Splice Variants of Murine Organic Anion Transporting Polypeptide 1b2 [作者：Schwabedissen, HEMZ; Ware, JA; Tirona, RG; Kim, RB,期刊：Molecular Pharmaceutics, 页码：1790-1797 , 文章类型： Article，,卷期：2009年6-6] The family of organic anion transporting polypeptides (OATPs) plays an important role in mediating the cellular uptake of numerous endogenous and exogenous compounds. Members of this family include human OATP1B1 and OATP...