- Melanin-concentrating hormone receptor 1 antagonists: Synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
[作者:KASAI SHIZUO; KAMAURA MASAHIRO; KAMATA MAKOTO; ASO KAZUYOSHI; OGINO HITOMI; NAKANO YOSHIHIDE; WATANABE KAORU; KAISHO TOMOKO; TAWADA MICHIKO; NAGISA YASUTAKA; TAKEKAWA SHIRO; KATO KOKI; SUZUKI NOBUHIRO; ISHIHARA YUJI,期刊:Bioorganic & Medicinal Chemistry, 页码:6261-6273 , 文章类型: Article,,卷期:2011年19-21]
- Melanin-concentrating hormone receptor 1 (MCHR1) antagonists have been studied as potential agents for the treatment of obesity. Initial structure-activity relationship studies of in-house hit compound 1a and subsequent ...
- Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group
[作者:MILKIEWICZ KAREN L; AIMONE LISA D; ALBOM MARK S; ANGELES THELMA S; CHANG HONG; GROBELNY JENNIFER V; HUSTEN JEAN; LOSARDO CHRISTINE; MIKNYOCZKI SHEILA; MURTHY SEETHA; ROLONSTEELE DAMARIS; UNDERINER TED L; WEINBERG LINDA R; WORRELL CANDACE S; ZEIGLER KELLI S; DORSEY BRUCE D,期刊:Bioorganic & Medicinal Chemistry, 页码:6274-6284 , 文章类型: Article,,卷期:2011年19-21]
- The hepatocyte growth factor (HGF)-c-Met signaling axis is involved in the mediation of many biological activities, including angiogenesis, proliferation, cell survival, cell motility, and morphogenesis. Dysregulation of...
- Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents
[作者:ISHII MARINA; JORGE SALOMAO DORIA; DE OLIVEIRA ALEX ALFREDO; PALACEBERL FANNY; SONEHARA IEDA YURIKO; MESQUITA PASQUALOTO KERLY FERNANDA; TAVARES LEOBERTO COSTA,期刊:Bioorganic & Medicinal Chemistry, 页码:6292-6301 , 文章类型: Article,,卷期:2011年19-21]
- A series of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives was synthesized and their activity screened in vitro against Staphylococcus aureus, Trypanosoma cruzi, and Candida albicans. The bioactivity...
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