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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共34条记录   Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes [作者：TSUCHIYA HIRONORI; UENO TAKAHIRO; MIZOGAMI MAKI,期刊：Bioorganic & Medicinal Chemistry, 页码：3410-3415 , 文章类型： Article，,卷期：2011年19-11] Amide-type pipecoloxylidide local anesthetics, bupivacaine, and ropivacaine, show cardiotoxic effects with the potency depending on stereostructures. Cardiotoxic drugs not only bind to cardiomyocyte membrane channels to ... Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study [作者：ELSAYED MAGDA A A; ABDELAZIZ NAGLAA I; ABDELAZIZ ALAA A M; ELAZAB ADEL S; ASIRI YOUSIF A; ELTAHIR KAMAL E H,期刊：Bioorganic & Medicinal Chemistry, 页码：3416-3424 , 文章类型： Article，,卷期：2011年19-11] New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4-trifuorobutane-1,3-dione 1. The newly synthesized compounds were investigated in vivo for t... Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents [作者：WYFFELS LEONIE; GRAY BRIAN D; BARBER CHRISTY; WOOLFENDEN JAMES M; PAK KOON Y; LIU ZHONGLIN,期刊：Bioorganic & Medicinal Chemistry, 页码：3425-3433 , 文章类型： Article，,卷期：2011年19-11] The aim of this study was the development of Tc-99m labeled bis(zinc(II)-dipicolylamine) (Zn2+-DPA) coordination complexes, and the in vivo evaluation of their usefulness as radiotracers for the detection of cell death. ... Probes for narcotic receptor mediated phenomena. Part 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans [作者：KIM JINHEE; DESCHAMPS JEFFREY R; ROTHMAN RICHARD B; DERSCH CHRISTINA M; FOLK JOHN E; CHENG KEJUN; JACOBSON ARTHUR E; RICE KENNER C,期刊：Bioorganic & Medicinal Chemistry, 页码：3434-3443 , 文章类型： Article，,卷期：2011年19-11] A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of thes... Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides [作者：KUMAR RAJU RANJITH; PERUMAL SUBBU; CARLOS MENENDEZ J; YOGEESWARI PERUMAL; SRIRAM DHARMARAJAN,期刊：Bioorganic & Medicinal Chemistry, 页码：3444-3450 , 文章类型： Article，,卷期：2011年19-11] The 1,3-dipolar cycloaddition of nitrile oxides generated in situ from benzohydroximinoyl chloride and triethylamine to 2-aminopyranopyridine-3-carbonitriles and 2-aminochromene-3-carbonitriles occurred chemoselectively ... 1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: Further insights into a class of triple re-uptake inhibitors [作者：MICHELI FABRIZIO; CAVANNI PAOLO; BETTATI MICHELA; BONANOMI GIORGIO; DI FABIO ROMANO; FAZZOLARI ELETTRA; MARCHIORO CARLA; ROSCIC MAJA; TARSI LUCA; VISENTINI FILIPPO; ZONZINI LAURA; WORBY ANGELA,期刊：Bioorganic & Medicinal Chemistry, 页码：3451-3461 , 文章类型： Article，,卷期：2011年19-11] Further exploration around the recently disclosed potent triple re-uptake inhibitor 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane led to the identification of a new series of potent triple re-up... Structure-activity relationship of 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts and 2N-substituted 4(5)-aryl-2-amino-1H-imidazoles as inhibitors of biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa [作者：STEENACKERS HANS P L; ERMOLATEV DENIS S; SAVALIYA BHARAT; DE WEERDT AMI; DE COSTER DAVID; SHAH ANAMIK; VAN DER EYCKEN ERIK V; DE VOS DIRK E; VANDERLEYDEN JOZEF; DE KEERSMAECKER SIGRID C J,期刊：Bioorganic & Medicinal Chemistry, 页码：3462-3473 , 文章类型： Article，,卷期：2011年19-11] A library of 80 1-substituted 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts and 54 2N-substituted 4(5)-aryl-2-amino-1H-imidazoles was synthesized and tested for the antagonistic effect against biofilm for... Synthesis and biological evaluation of loxoprofen derivatives [作者：YAMAKAWA NAOKI; SUEMASU SHINTARO; MATOYAMA MASAAKI; TANAKA KENICHIRO; KATSU TAKASHI; MIYATA KEISHI; OKAMOTO YOSHINARI; OTSUKA MASAMI; MIZUSHIMA TOHRU,期刊：Bioorganic & Medicinal Chemistry, 页码：3299-3311 , 文章类型： Article，,卷期：2011年19-11] Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX acti... Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors [作者：LUAN XUDONG; GAO CHUNMEI; ZHANG NANNAN; CHEN YUZONG; SUN QINSHENG; TAN CHUNYAN; LIU HONGXIA; JIN YIBAO; JIANG YUYANG,期刊：Bioorganic & Medicinal Chemistry, 页码：3312-3319 , 文章类型： Article，,卷期：2011年19-11] VEGFR-2 and Src kinases both play important roles in cancers. In certain cancers, Src works synergistically with VEGFR-2 to promote its activation. Development of multi-target drugs against VEGFR-2 and Src is of therapeu... Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans [作者：EUGENIA CHIARI MARIA; VERA DOMINGO MARIANO A; MARIA PALACIOS SARA; CECILIA CARPINELLA MARIA,期刊：Bioorganic & Medicinal Chemistry, 页码：3474-3482 , 文章类型： Article，,卷期：2011年19-11] To aid the pharmaceutical and cosmetic industry in the development of alternatives to prevent melanin-related hyperpigmentation disorders, the plant Dalea elegans was submitted to fractionation with the aim of obtaining ... Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles [作者：KHOJE ABHIJIT DATTA; CHARNOCK COLIN; WAN BAOJIE; FRANZBLAU SCOTT; GUNDERSEN LISELOTTE,期刊：Bioorganic & Medicinal Chemistry, 页码：3483-3491 , 文章类型： Article，,卷期：2011年19-11] 6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tuberculosis (Mtb) in vitro. Analogs modified in the six-membered ring (imidazopyridines, pyrrolopyridines, benzimidazoles... Synthesis and in vitro evaluation of novel pro-drugs for the treatment of nephropathic cystinosis [作者：OMRAN ZIAD; MOLONEY KEVIN A; BENYLLES AMINA; KAY GRAEME; KNOTT RACHEL M; CAIRNS DONALD,期刊：Bioorganic & Medicinal Chemistry, 页码：3492-3496 , 文章类型： Article，,卷期：2011年19-11] As part of our continuing work to obtain new pro-drugs for the treatment of nephropathic cystinosis, a number of glutaric and succinic acid derivatives of cystamine have been designed, synthesised and biologically evalua... Hairpin conformation of an 11-mer peptide [作者：MEI CHONG GEOK; JAHR NICOLE; SINGER DAVID; BERGER STEFAN,期刊：Bioorganic & Medicinal Chemistry, 页码：3497-3501 , 文章类型： Article，,卷期：2011年19-11] An 11-mer peptide taken from a subsequence of the human protein ubiquitin was synthesized. The peptide has been fully characterized by NMR spectroscopy using chemical shift analysis and by NOE measurements. The conformat... Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1) [作者：KOUZNETSOVA VALENTINA L; TSIGELNY IGOR F; NAGLE MEGHA A; NIGAM SANJAY K,期刊：Bioorganic & Medicinal Chemistry, 页码：3320-3340 , 文章类型： Article，,卷期：2011年19-11] Organic anion transporter 1 (Oat1), first identified as NKT, is a multispecific transporter responsible for the handling of drugs and toxins in the kidney and choroid plexus, but its normal physiological role appears to ... Surface modified dendrimers: Synthesis and characterization for cancer targeted drug delivery [作者：SHARMA ANUPAMA; GAUTAM SURYA PRAKASH; GUPTA ARUN KUMAR,期刊：Bioorganic & Medicinal Chemistry, 页码：3341-3346 , 文章类型： Article，,卷期：2011年19-11] Dendrimers represents a highly branched three-dimensional structure that provides a high degree of surface functionality and versatility. PAMAM dendrimers are used as well-defined nanocontainers to conjugate, complex or ... Synthesis and characterization of selective dopamine D-2 receptor ligands using aripiprazole as the lead compound [作者：VANGVERAVONG SUWANNA; ZHANG ZHANBIN; TAYLOR MICHELLE; BEARDEN MELISSA; XU JINBIN; CUI JINQUAN; WANG WEI; LUEDTKE ROBERT R; MACH ROBERT H,期刊：Bioorganic & Medicinal Chemistry, 页码：3502-3511 , 文章类型： Article，,卷期：2011年19-11] A series of compounds structurally related to aripiprazole (1), an atypical antipsychotic and antidepressant used clinically for the treatment of schizophrenia, bipolar disorder, and depression, have been prepared and ev...