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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共28条记录   New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis [作者：KASHIWADA YOSHIKI; NISHIMURA KAZUYA; KURIMOTO SHINICHIRO; TAKAISHI YOSHIHISA,期刊：Bioorganic & Medicinal Chemistry, 页码：2790-2796 , 文章类型： Article，,卷期：2011年19-9] Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes,... Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids [作者：KAKIZAWA TAEKO; SANJOH AKIRA; KOBAYASHI AKANE; HATTORI YASUNAO; TERUYA KENTA; AKAJI KENICHI,期刊：Bioorganic & Medicinal Chemistry, 页码：2785-2789 , 文章类型： Article，,卷期：2011年19-9] A recombinant form of BACE1 (beta-site amyloid precursor protein cleaving enzyme-1) corresponding to positions 46-454 of the extracellular domain of the original membrane enzyme was prepared. The recombinant BACE1 (rBACE... Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors [作者：ZHU LINA; JIN JING; LIU CHANG; ZHANG CHONGJING; SUN YAN; GUO YANSHEN; FU DECAI; CHEN XIAOGUANG; XU BAILING,期刊：Bioorganic & Medicinal Chemistry, 页码：2797-2807 , 文章类型： Article，,卷期：2011年19-9] A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC... Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity [作者：MOUTEVELISMINAKAKIS PANAGIOTA; PAPAVASSILOPOULOU ELENI; MICHAS GEORGE; GEORGIKOPOULOU KALLIOPI; RAGOUSSI MARIAELENI; NEOPHYTOU NIKI; ZOUMPOULAKIS PANAGIOTIS; MAVROMOUSTAKOS THOMAS; HADJIPAVLOULITINA DIMITRA,期刊：Bioorganic & Medicinal Chemistry, 页码：2888-2902 , 文章类型： Article，,卷期：2011年19-9] A new class of 2-pyrrolidinone derivatives was designed, synthesized, and tested for their antioxidant and anti-inflammatory activities. The compounds were evaluated for their inhibitory activity against LOX. The most po... 2-Arylbenzothiazole, benzoxazole and benzimidazole derivatives as fluorogenic substrates for the detection of nitroreductase and aminopeptidase activity in clinically important bacteria [作者：CELLIER MARIE; FABREGA OLIVIER J; FAZACKERLEY ELIZABETH; JAMES ARTHUR L; ORENGA SYLVAIN; PERRY JOHN D; SALWATURA VINDHYA L; STANFORTH STEPHEN P,期刊：Bioorganic & Medicinal Chemistry, 页码：2903-2910 , 文章类型： Article，,卷期：2011年19-9] A series of 2-(2-nitrophenyl) benzothiazole 7, 2-(2-nitrophenyl) benzoxazole 10 and 2-(2-nitrophenyl) benzimidazole 13 derivatives have been synthesised and assessed as indicators of nitroreductase activity across a rang... Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging [作者：LI ZIJING; REN HUIYING; CUI MENGCHAO; DEUTHERCONRAD WINNIE; TANG RUIKUN; STEINBACH JOERG; BRUST PETER; LIU BOLI; JIA HONGMEI,期刊：Bioorganic & Medicinal Chemistry, 页码：2911-2917 , 文章类型： Article，,卷期：2011年19-9] We report the synthesis and evaluation of 4-benzylpiperazine ligands (BP-CH3, BP-F, BP-Br, BP-I, and BP-NO2) as potential sigma(1) receptor ligands. The X-ray crystal structure of BP-Br, which crystallized with monoclini... Comparing micellar, hemolytic, and antibacterial properties of di- and tricarboxyl dendritic amphiphiles [作者：MAISURIA BHADRESHKUMAR B; ACTIS MARCELO L; HARDRICT SHAUNTRECE N; FALKINHAM JOSEPH O III; COLE MICHAEL F; CIHLAR RONALD L; PETERS STEPHEN M; MACRI RICHARD V; SUGANDHI EKO W; WILLIAMS ANDRE A; POPPE MICHAEL A; ESKER ALAN R; GANDOUR RICHARD D,期刊：Bioorganic & Medicinal Chemistry, 页码：2918-2926 , 文章类型： Article，,卷期：2011年19-9] Homologous dicarboxyl dendritic amphiphiles-RCONHC(CH3)(CH2CH2COOH)(2), 4(n); and ROCO-NHC(CH3)(CH2CH2COOH)(2), 5(n), where R = n-CnH2n+1 and n = 13-22 carbon atoms-were synthesized. Critical micelle concentrations (CMCs... Development and SAR of functionally selective allosteric modulators of GABA(A) receptors [作者：ALHAMBRA CRISTOBAL; BECKER CHRIS; BLAKE TIMOTHY; CHANG AMY HUIFANG; DAMEWOOD JAMES R JR; DANIELS THALIA; DEMBOFSKY BRUCE T; GURLEY DAVID A; HALL JAMES E; HERZOG KEITH J; HORCHLER CAREY L; OHNMACHT CYRUS J; SCHMIESING RICHARD JON; DUDLEY ADAM; RIBADENEIRA MARIA D; KNAPPENBERGER KATHERINE S; MACIAG CARLA; STEIN MARK M; CHOPRA MANINDER; LIU XIAODONG F; CHRISTIAN EDWARD P; ARRIZA JEFFREY L; CHAPDELAINE MARC J,期刊：Bioorganic & Medicinal Chemistry, 页码：2927-2938 , 文章类型： Article，,卷期：2011年19-9] Positive modulators at the benzodiazepine site of alpha 2- and alpha 3-containing GABA(A) receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, we have discovered two series of compounds that are... Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity [作者：OKITSU TAKASHI; SATO KANA; IWATSUKA KINYA; SAWADA NATSUMI; NAKAGAWA KIMIE; OKANO TOSHIO; YAMADA SHOYA; KAKUTA HIROKI; WADA AKIMORI,期刊：Bioorganic & Medicinal Chemistry, 页码：2939-2949 , 文章类型： Article，,卷期：2011年19-9] Retinoid X receptor (RXR) agonists are interesting candidates for the treatment of metabolic syndrome. 9-Cis-retinoic acid (9cRA: 1) is a natural RXR agonist, that also works as a retinoic acid receptor (RAR) agonist. Th... Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy) propyl] adenine [作者：RUIZ JACQUELINE; BEADLE JAMES R; BULLER R MARK; SCHREIWER JILL; PRICHARD MARK N; KEITH KATHY A; LEWIS KENNETH C; HOSTETLER KARL Y,期刊：Bioorganic & Medicinal Chemistry, 页码：2950-2958 , 文章类型： Article，,卷期：2011年19-9] Alkoxyalkyl esters of cidofovir (CDV) are orally active agents which inhibit the replication of a variety of double stranded DNA (dsDNA) viruses including variola, vaccinia, ectromelia, herpes simplex virus, cytomegalovi... Metabolic stability of 6,7-dialkoxy-4-(2-, 3-and 4-[F-18]fluoroanilino)quinazolines, potential EGFR imaging probes [作者：VASDEV NEIL; DORFF PETER N; ONEIL JAMES P; CHIN FREDERICK T; HANRAHAN STEPHEN; VANBROCKLIN HENRY F,期刊：Bioorganic & Medicinal Chemistry, 页码：2959-2965 , 文章类型： Article，,卷期：2011年19-9] Epidermal growth factor receptors (EGFR), upregulated in many tumor types, have been a target for therapeutic development and molecular imaging. The objective of this study was to evaluate the distribution and metabolic ... Development of new indole-derived neuroprotective agents [作者：MOHAREB RAFAT M; AHMED HANAA H; ELMEGEED GAMAL A; ABDELHALIM MERVAT M; SHAFIC REHAM W,期刊：Bioorganic & Medicinal Chemistry, 页码：2966-2974 , 文章类型： Article，,卷期：2011年19-9] There is a great deal of interest in neurotrophin therapy to prevent neuronal degeneration. The present study aimed at synthesizing new functionalized indole derivatives with structures justifying neuroprotective activit... Synthesis of 4 beta-carbamoyl epipodophyllotoxins as potential antitumour agents [作者：KAMAL AHMED; KUMAR B ASHWINI; SURESH PAIDAKULA; JUVEKAR AARTI; ZINGDE SUREKHA,期刊：Bioorganic & Medicinal Chemistry, 页码：2975-2979 , 文章类型： Article，,卷期：2011年19-9] A series of new 4 beta-carbamoyl epipodophyllotoxin analogues have been synthesized and evaluated for their anticancer activity against eleven cancer cell lines including Zr-75-1, MCF7, KB, Gurav, DWD, Colo 205, A-549, H... Aromatic radiofluorination and biological evaluation of 2-aryl-6-[F-18] fluorobenzothiazoles as a potential positron emission tomography imaging probe for beta-amyloid plaques [作者：LEE BYUNG CHUL; KIM JI SUN; KIM BOM SAHN; SON JI YEON; HONG SOO KYUNG; PARK HYUN SOO; MOON BYUNG SEOK; JUNG JAE HO; JEONG JAE MIN; KIM SANG EUN,期刊：Bioorganic & Medicinal Chemistry, 页码：2980-2990 , 文章类型： Article，,卷期：2011年19-9] To develop agents for radionuclide imaging Ab plaques in vivo, we prepared three fluorine-substituted analogs of arylbenzothiazole class; compound 2 has a high affinity for Ab (K-i = 5.5 nM) and the specific binding to A... Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development [作者：SU JING; WANG QIANG; FENG JINHONG; ZHANG CONG; ZHU DEYU; WEI TIANDI; XU WENFANG; GU LICHUAN,期刊：Bioorganic & Medicinal Chemistry, 页码：2991-2996 , 文章类型： Article，,卷期：2011年19-9] Human aminopeptidase N (hAPN) is an appealing objective for the development of anti-cancer agents. The absence of mammalian APN experimental structure negatively impinges upon the progression of structure-based drug desi... Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [C-11]celecoxib and its major metabolite [C-11]SC-62807 and in vivo PET evaluation [作者：TAKASHIMAHIRANO MISATO; TAKASHIMA TADAYUKI; KATAYAMA YUMIKO; WADA YASUHIRO; SUGIYAMA YUICHI; WATANABE YASUYOSHI; DOI HISASHI; SUZUKI MASAAKI,期刊：Bioorganic & Medicinal Chemistry, 页码：2997-3004 , 文章类型： Article，,卷期：2011年19-9] Synthesis of [C-11] celecoxib, a selective COX-2 inhibitor, and [C-11]SC-62807, a major metabolite of celecoxib, were achieved and the potential of these PET probes for assessing the function of drug transporter in bilia...