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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Initiation of protein synthesis: a target for antimicrobials [作者：Brandi, L; Fabbretti, A; Pon, CL; Dahlberg, AE; Gualerzi, CO,期刊：Expert Opinion on Therapeutic Targets, 页码：519-534 , 文章类型： Review，,卷期：2008年12-5] Background: Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. ... Protein kinase C isozymes as potential therapeutic targets in immune disorders [作者：Lee, MR; Duan, W; Tan, SL,期刊：Expert Opinion on Therapeutic Targets, 页码：535-552 , 文章类型： Review，,卷期：2008年12-5] Background: Members of the protein kinase C (PKC) family are key signalling mediators in immune responses, and pharmacological inhibition of PKCs may be useful for treating immune-mediated diseases. Objective: To review ... Novel therapeutic targets in the treatment of IBD [作者：Kaser, A; Tilg, H,期刊：Expert Opinion on Therapeutic Targets, 页码：553-563 , 文章类型： Review，,卷期：2008年12-5] Background: Advances in mucosal immunology have revealed a broad set of new therapeutic targets to resolve inflammation and symptoms in patients with inflammatory bowel diseases (IBD). Objective: Despite the enormous suc... The therapeutic potential of neuronal K(v)7 (KCNQ) channel modulators: an update [作者：Gribkoff, VK,期刊：Expert Opinion on Therapeutic Targets, 页码：565-581 , 文章类型： Review，,卷期：2008年12-5] Background: Neuronal KCNQ channels (K(V)7.2-5) represent attractive targets for the development of therapeutics for chronic and neuropathic pain, migraine, epilepsy and other neuronal hyperexcitability disorders, althoug... Upregulating substance P levels to treat obstructive sleep apnea [作者：Ursavas, A,期刊：Expert Opinion on Therapeutic Targets, 页码：583-588 , 文章类型： Review，,卷期：2008年12-5] Background: The neuropeptide (tachykinin) substance P is widely distributed in the central and peripheral nervous systems. Substance P has been suggested to function as a neurotransmitter, cotransmitter, or neuromodulato... Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer [作者：Yuen, JSP; Macaulay, VM,期刊：Expert Opinion on Therapeutic Targets, 页码：589-603 , 文章类型： Review，,卷期：2008年12-5] Background: The type 1 insulin-like growth factor receptor (IGF1R) plays a critical role in transformation, invasion and apoptosis protection, and is an attractive cancer treatment target. Objective: To review IGF1R anti... Targeting of extracellular proteases required for the progression of pancreatic cancer [作者：Ardito, CM; Briggs, CD; Crawford, HC,期刊：Expert Opinion on Therapeutic Targets, 页码：605-619 , 文章类型： Review，,卷期：2008年12-5] Background: Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States. Its lethality is due, in large part, to its resistance to traditional chemotherapeutics. As a r... Chemokines and antagonists in non-Hodgkin's lymphoma [作者：Golay, J; Introna, M,期刊：Expert Opinion on Therapeutic Targets, 页码：621-635 , 文章类型： Review，,卷期：2008年12-5] Background: Chemokines and their receptors are a large family of molecules that control the trafficking of immune cells during their development and in response to inflammation. Non Hodgkin's lymphoma (NHL) derives from ... Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications [作者：Huang, C; Li, M; Chen, CY; Yao, QZ,期刊：Expert Opinion on Therapeutic Targets, 页码：637-645 , 文章类型： Review，,卷期：2008年12-5] Background: Small interfering RNA (siRNA) has become a powerful tool in knocking down or silencing gene expression in most cells. siRNA-based therapy has shown great promise for many diseases such as cancer. Major target... The P2X(7) receptor as a therapeutic target [作者：Romagnoli, R; Baraldi, PG; Cruz-Lopez, O; Lopez-Cara, C; Preti, D; Borea, PA; Gessi, S,期刊：Expert Opinion on Therapeutic Targets, 页码：647-661 , 文章类型： Review，,卷期：2008年12-5] Background: The P2X7 receptor is present in a variety of cell types involved in pain, inflammatory processes and neuroclegenerative conditions, thus it may be an appealing target for pharmacological intervention. The ext...