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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   From hyperglycemia to AGE-RAGE interaction on the cell surface: A dangerous metabolic route for diabetic patients [作者：Nogueira-Machado, JA; Chaves, MM,期刊：Expert Opinion on Therapeutic Targets, 页码：871-882 , 文章类型： Review，,卷期：2008年12-7] Background: Diabetes mellitus constitutes a serious public health problem. Recent advances in therapies are unable to control its vascular complications. New medications have been suggested but without comprehensive know... Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges [作者：Rokosz, LL; Beasley, JR; Carroll, CD; Lin, T; Zhao, J; Appell, KC; Webb, ML,期刊：Expert Opinion on Therapeutic Targets, 页码：883-903 , 文章类型： Review，,卷期：2008年12-7] At the time of writing, there are seven marketed kinase inhibitor drugs. The first kinase inhibitor, imatinib mesilate (Gleevec (R), Novartis), came to market in 2001, an inhibitor of the breakpoint cluster region (BCR)/... Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and forkhead signaling? [作者：Maiese, K; Chong, ZZ; Shang, YC; Hou, JL,期刊：Expert Opinion on Therapeutic Targets, 页码：905-916 , 文章类型： Review，,卷期：2008年12-7] Background: Disease entities such as diabetes, neurodegeneration and cardiovascular disorders affect a significant portion of the world's population. Objective: Given that cellular survival and longevity in multiple diso... The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury [作者：Suzuki, JI; Ogawa, M; Muto, S; Yamaguchi, Y; Itai, A; Isobe, M,期刊：Expert Opinion on Therapeutic Targets, 页码：783-794 , 文章类型： Article，,卷期：2008年12-7] Objective: Plasminogen activator inhibitor (PAI)-1 plays a role in neointimal formation after percutaneous coronary intervention (PCI), the effect of overexpression or lack of PAI-1 is controversial. Murine arterial inju... MAPK phosphatases as novel targets for rheumatoid arthritis [作者：Ralph, JA; Morand, EF,期刊：Expert Opinion on Therapeutic Targets, 页码：795-808 , 文章类型： Review，,卷期：2008年12-7] Background: Rheumatoid arthritis (RA) represents a challenge for therapeutic interventions due to complex inflammatory signalling pathways underlying its pathogenesis. The MAPK signalling network, a major effector limb o... Established and emerging vascular risk factors and the development of aortic stenosis: an opportunity for prevention? [作者：Tziomalos, K; Athyros, VG; Karagiannis, A; Mikhailidis, DP,期刊：Expert Opinion on Therapeutic Targets, 页码：809-820 , 文章类型： Review，,卷期：2008年12-7] Background: Aortic stenosis (AS) is the commonest valvular heart disease in the developed world. It is becoming increasingly accepted that the pathogenesis of AS and of its preceding abnormalities, aortic valve sclerosis... Molecular diagnosis of the viral component in cardiomyopathies: pathophysiological, clinical and therapeutic implications [作者：Halapas, A; Pissimissis, N; Lembessis, P; Rizos, I; Rigopoulos, AG; Kremastinos, DT; Koutsilieris, M,期刊：Expert Opinion on Therapeutic Targets, 页码：821-836 , 文章类型： Review，,卷期：2008年12-7] Background: Myocarditis is defined as the inflammation of myocardium associated with cardiac dysfunction. Despite this clear-cut definition, diagnosis and etiologic treatment continue to create considerable debate. Viral... Eag1 as a cancer target [作者：Pardo, LA; Suhmer, W,期刊：Expert Opinion on Therapeutic Targets, 页码：837-843 , 文章类型： Review，,卷期：2008年12-7] Background: Ion channels are drug targets for many diseases but have only recently started to be regarded as potential primary cancer targets. Many types of ion channels have been identified that could be useful in cance... Potential role of EPB41L3 (protein 4.1 B/Dal-1) as, a target for treatment of advanced prostate cancer [作者：Bernkopf, DB; Williams, ED,期刊：Expert Opinion on Therapeutic Targets, 页码：845-853 , 文章类型： Review，,卷期：2008年12-7] Background: Loss of erythrocyte membrane protein band 4.1-like 3 (EPB41L-3; aliases: protein 4.1B, differentially expressed in adenocarcinoma of the lung-1 (Dal-1)) expression has been implicated in tumor progression. Ob... Molecular targeting of E3 ligases - a therapeutic approach for cancer [作者：Lakshmanan, M; Bughani, U; Duraisamy, S; Diwan, M; Dastidar, S; Ray, A,期刊：Expert Opinion on Therapeutic Targets, 页码：855-870 , 文章类型： Review，,卷期：2008年12-7] Background: The ubiquitin-proteasomal degradation pathway plays a critical role in protein degradation and regulates a wide variety of cellular functions. This highly conserved post-translational modification of proteoly...