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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Diagnosis of viral cardiomyopathy by analysis of peripheral blood? [作者：Fett, JD,期刊：Expert Opinion on Therapeutic Targets, 页码：1073-1075 , 文章类型： Editorial Material，,卷期：2008年12-9] Polymerase chain reaction testing has become an important tool in assessing the role of virus in inflammatory cardiomyopathies, including fulminant myocarditis, lymphocytic myocarditis, peripartum cardiomyopathy, unknown... Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: the role of bosentan [作者：Antoniu, SA,期刊：Expert Opinion on Therapeutic Targets, 页码：1077-1084 , 文章类型： Review，,卷期：2008年12-9] Background: Idiopathic pulmonary fibrosis (IPF) is a rapidly lethal disease characterized by anarchic, progressive fibrosis. Pulmonary fibrosis is the result of interactions between many effector cells and cytokines and ... Targeting tumor necrosis factor alpha in psoriasis and psoriatic arthritis [作者：Fantuzzi, F; Del Giglio, M; Gisondi, P; Girolomoni, G,期刊：Expert Opinion on Therapeutic Targets, 页码：1085-1096 , 文章类型： Review，,卷期：2008年12-9] Background: Psoriasis is an immune-mediated chronic inflammatory disease triggered and maintained by inflammatory mediators, including TNF-alpha. Objective/methods: To summarize the role of anti-TNF-alpha agents psoriasi... Regulation of pituitary adenylyl cyclase-activating polypeptide (PACAP, ADCYAP1: adenylyl cyclase-activating polypeptide 1) in the treatment of schizophrenia [作者：Matsttzaki, S; Tohyama, M,期刊：Expert Opinion on Therapeutic Targets, 页码：1097-1108 , 文章类型： Review，,卷期：2008年12-9] Background: Deficiency of pituitary adenylyl cyclase-activating polypeptide (PACAP) and its specific receptor, PAC1, causes a schizophrenia-like phenotype in mice. In addition, the relation of the PACAP and PAC1 genes to... NF-kappa B in carcinoma therapy and prevention [作者：Brown, M; Cohen, J; Arun, P; Chen, Z; Van Waes, C,期刊：Expert Opinion on Therapeutic Targets, 页码：1109-1122 , 文章类型： Review，,卷期：2008年12-9] Background: NF-kappa B includes a family of signal-activated transcription factors that normally regulate responses to injury and infection but which are aberrantly activated in many carcinomas. Objective: To review the ... Development of therapeutic approaches to 'triple negative' phenotype breast cancer [作者：Shiu, KK; Tan, DSP; Reis, JS,期刊：Expert Opinion on Therapeutic Targets, 页码：1123-1137 , 文章类型： Review，,卷期：2008年12-9] Background: Triple negative phenotype (TNP) breast cancers are characterised by the lack of expression of oestrogen and progesterone receptors and of human EGF receptor 2 (HER2) overexpression/amplification. This subgrou... Akt as a therapeutic target in cancer [作者：Steelman, LS; Stadelman, KM; Chappell, WH; Horn, S; Basecke, J; Cervello, M; Nicoletti, F; Libra, M; Stivala, F; Martelli, AM; McCubrey, JA,期刊：Expert Opinion on Therapeutic Targets, 页码：1139-1165 , 文章类型： Review，,卷期：2008年12-9] Background: The phosphatidylinositol 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/v-akt murine thymoma viral oncogene homolog (Akt)/mammalian target of rapamycin (mTOR) pathway is central in the transmission of ... Muscarinic acetylcholine receptors as therapeutic targets for obesity [作者：Maresca, A; Supuran, CT,期刊：Expert Opinion on Therapeutic Targets, 页码：1167-1175 , 文章类型： Review，,卷期：2008年12-9] Background: There are five types of muscarinic acetylcholine receptors (mAChRs), M-1 - M-5, which regulate several central and peripheral functions. Transgenic mice deficient in these receptors have been generated. Objec... Ghrelin and ghrelin receptor inhibitors: agents in the treatment of obesity [作者：Soares, JB; Roncon-Albuquerque, R; Leite-Moreira, A,期刊：Expert Opinion on Therapeutic Targets, 页码：1177-1189 , 文章类型： Review，,卷期：2008年12-9] Background: Current medical treatment of obesity is highly ineffective. Soon after its discovery as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R), ghrelin was shown to stimulate food intake (... Voltage-gated Na+ channels: Potential for beta subunits as therapeutic targets [作者：Brackenbury, WJ; Isom, LL,期刊：Expert Opinion on Therapeutic Targets, 页码：1191-1203 , 文章类型： Review，,卷期：2008年12-9] Background: Voltage gated Na+ channels (VGSCs) contain a pore-forming a subunit and one or more beta subunits. VGSCs are involved in a wide variety of pathophysiologies, including epilepsy, cardiac arrhythmia, multiple s... Could starvation minimize chemotherapy-induced toxicities? [作者：Russo, A; Rizzo, S,期刊：Expert Opinion on Therapeutic Targets, 页码：1205-1207 , 文章类型： Article，,卷期：2008年12-9] Background: In their recent paper Raffaghello, et al. examined the use of short-term starvation (STS) to induce differential stress resistance (DSR), that is increased protection of normal over cancer cells against chemo...