- Novel Mechanism for Fc epsilon RI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production
[作者:Pullen, NA; Barnstein, BO; Falanga, YT; Wang, ZQ; Suzuki, R; Tamang, TDL; Khurana, MC; Harry, EA; Draber, P; Bunting, KD; Mizuno, K; Wilson, BS; Ryan, JJ,期刊:Journal of Biological Chemistry, 页码:2045-2054 , 文章类型: Article,,卷期:2012年287-3]
- Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is swiftly and transiently induced by activation of the high affi...
- Hydrolysis of Secreted Sialoglycoprotein Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis
[作者:Lewis, WG; Robinson, LS; Perry, J; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL,期刊:Journal of Biological Chemistry, 页码:2079-2089 , 文章类型: Article,,卷期:2012年287-3]
- Bacterial vaginosis (BV) is a common polymicrobial imbalance of the vaginal flora associated with a wide variety of obstetric and gynecologic complications including serious infections and preterm birth. As evidenced by ...
- Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation
[作者:Fang, Z; Zhang, T; Dizeyi, N; Chen, S; Wang, HY; Swanson, KD; Cai, CM; Balk, SP; Yuan, X,期刊:Journal of Biological Chemistry, 页码:2090-2098 , 文章类型: Article,,卷期:2012年287-3]
- Androgen receptor (AR) plays a central role in prostate cancer (PCa) growth, with androgen deprivation or AR down-regulation causing cell-cycle arrest and accumulation of the p27 cyclin-dependent kinase inhibitor. The mo...
- V2 Vasopressin Receptor (V2R) Mutations in Partial Nephrogenic Diabetes Insipidus Highlight Protean Agonism of V2R Antagonists
[作者:Takahashi, K; Makita, N; Manaka, K; Hisano, M; Akioka, Y; Miura, K; Takubo, N; Iida, A; Ueda, N; Hashimoto, M; Fujita, T; Igarashi, T; Sekine, T; Iiri, T,期刊:Journal of Biological Chemistry, 页码:2099-2106 , 文章类型: Article,,卷期:2012年287-3]
- Inactivating mutations of the V2 vasopressin receptor (V2R) cause cross-linked congenital nephrogenic diabetes insipidus (NDI), resulting in renal resistance to the antidiuretic hormone AVP. In two families showing parti...
- Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain
[作者:Zuo, XP; Sheng, JP; Lau, HT; McDonald, CM; Andrade, M; Cullen, DE; Bell, FT; Iacovino, M; Kyba, M; Xu, GL; Li, XJ,期刊:Journal of Biological Chemistry, 页码:2107-2118 , 文章类型: Article,,卷期:2012年287-3]
- Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite these findings, it remains elusive how DNA ...
- Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
[作者:Egger, S; Chaikuad, A; Klimacek, M; Kavanagh, KL; Oppermann, U; Nidetzky, B,期刊:Journal of Biological Chemistry, 页码:2119-2129 , 文章类型: Article,,卷期:2012年287-3]
- Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. The catalytic reaction of UGDH is ...
- Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification
[作者:Pastore, C; Topalidou, I; Forouhar, F; Yan, AC; Levy, M; Hunt, JF,期刊:Journal of Biological Chemistry, 页码:2130-2143 , 文章类型: Article,,卷期:2012年287-3]
- Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs...
- Interferon-gamma Alters Downstream Signaling Originating from Epidermal Growth Factor Receptor in Intestinal Epithelial Cells FUNCTIONAL CONSEQUENCES FOR ION TRANSPORT
[作者:Paul, G; Marchelletta, RR; McCole, DF; Barrett, KE,期刊:Journal of Biological Chemistry, 页码:2144-2155 , 文章类型: Article,,卷期:2012年287-3]
- The epidermal growth factor receptor (EGFr) regulates many cellular functions, such as proliferation, apoptosis, and ion transport. Our aim was to investigate whether long term treatment with interferon-gamma (IFN-gamma)...
- Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy
[作者:Wang, YC; Pinto, JR; Solis, RS; Dweck, D; Liang, JS; Diaz-Perez, Z; Ge, Y; Walker, JW; Potter, JD,期刊:Journal of Biological Chemistry, 页码:2156-2167 , 文章类型: Article,,卷期:2012年287-3]
- The R21C substitution in cardiac troponin I (cTnI) is the only identified mutation within its unique N-terminal extension that is associated with hypertrophic cardiomyopathy (HCM) in man. Particularly, this mutation is l...
- Engagement of alpha IIb beta 3 (GPIIb/IIIa) with alpha nu beta 3 Integrin Mediates Interaction of Melanoma Cells with Platelets A CONNECTION TO HEMATOGENOUS METASTASIS
[作者:Lonsdorf, AS; Kramer, BF; Fahrleitner, M; Schonberger, T; Gnerlich, S; Ring, S; Gehring, S; Schneider, SW; Kruhlak, MJ; Meuth, SG; Nieswandt, B; Gawaz, M; Enk, AH; Langer, HF,期刊:Journal of Biological Chemistry, 页码:2168-2178 , 文章类型: Article,,卷期:2012年287-3]
- A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here...
- Structure-based Analysis of VDAC1 Protein DEFINING OLIGOMER CONTACT SITES
[作者:Geula, S; Naveed, H; Liang, J; Shoshan-Barmatz, V,期刊:Journal of Biological Chemistry, 页码:2179-2190 , 文章类型: Article,,卷期:2012年287-3]
- The outer mitochondrial membrane protein, the voltage-dependent anion channel (VDAC), is increasingly implicated in the control of apoptosis. Oligomeric assembly of VDAC1 was shown to be coupled to apoptosis induction, w...
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