The microtubule-stabilizing agent (+)-peloruside A has emerged as a potential therapeutic agent for the treatment of cancer. Two total syntheses have been published and these reports have stimulated additional studies...
Significant advances have been made in the development of therapeutic cancer vaccines, with vaccines for renal, colorectal and prostate cancers showing real promise. This review describes progress in the development o...
Insulin-like growth factor (IGF)-mediated signaling pathways have long been recognized as important targets for cancer therapy. The development of antibodies against the IGF type I receptor (IGF-IR) started in the ear...
Recent progress in the understanding of polyketide synthase (PKS) continues to fuel the growth of combinatorial biosynthesis for natural product structural diversity. The structural analysis of many components of PKS,...
G protein-coupled receptors constitute one of the major classes of drug targets, so understanding the mechanisms of signaling through these receptors is of great importance. This review covers some of the recent advan...
Since the discovery of RNA interference (RNAi) as a means to silence the expression of specific genes, small interfering RNA (siRNA) oligonucleotides have been recognized as powerful tools for targeting therapeuticall...
The number of small interfering RNA (siRNA)-based therapeutics that are in or nearing human clinical trials is rapidly expanding. This review summarizes recent in vivo data obtained from studies on siRNA therapeutics ...
Hematopoietic stem cell-targeted gene therapy using replication-incompetent viral vectors holds promise for the treatment of lympho-hematopoietic disorders. In the last several years, success has been obtained in a se...
Immunoinformatics is an emerging specialization of bioinformatics that focuses upon the structure, function and interactions of the molecules involved in immunity. Two major cell types, T-cells and B-cells, play signi...
In recent years, PEGylation has become widely used as a post-production modification methodology for improving the biomedical efficacy and physicochemical properties of therapeutic proteins. Several marketed drugs tha...