- Biofeedback Is Superior to Electrogalvanic Stimulation and Massage for Treatment of Levator Ani Syndrome
[作者:Chiarioni, G; Nardo, A; Vantini, I; Romito, A; Whitehead, WE,期刊:Gastroenterology, 页码:1321-1329 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Levator ani syndrome (LAS) might be treated using biofeedback to teach pelvic floor relaxation, electrogalvanic stimulation (EGS), or massage of levator muscles. We performed a prospective, randomized ...
- Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study
[作者:Rauch, A; Kutalik, Z; Descombes, P; Cai, T; Di Iulio, J; Mueller, T; Bochud, M; Battegay, M; Bernasconi, E; Borovicka, J; Colombo, S; Cerny, A; Dufour, JF; Furrer, H; Gunthard, HF; Heim, M; Hirschel, B; Malinverni, R; Moradpour, D; Mullhaupt, B; Witteck, A; Beckmann, JS; Berg, T; Bergmann, S; Negro, F; Telenti, A; Bochud, PY,期刊:Gastroenterology, 页码:1338-U173 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for hos...
- SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease
[作者:Schwimmer, JB; Dunn, W; Norman, GJ; Pardee, PE; Middleton, MS; Kerkar, N; Sirlin, CB,期刊:Gastroenterology, 页码:1357-U197 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: The appropriate alanine aminotransferase (ALT) threshold value to use for diagnosis of chronic liver disease in children is unknown. We sought to develop gender-specific, biology-based, pediatric ALT t...
- Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection
[作者:McHutchison, J; Goodman, Z; Patel, K; Makhlouf, H; Rodriguez-Torres, M; Shiffman, M; Rockey, D; Husa, P; Chuang, WL; Levine, R; Jonas, M; Theodore, D; Brigandi, R; Webster, A; Schultz, M; Watson, H; Stancil, B; Gardner, S,期刊:Gastroenterology, 页码:1365-U208 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Farglitazar (GI262570), an insulin-sensitizing agent, selectively binds and activates peroxisome proliferator-activated receptor gamma (PPAR gamma) and inhibits stellate cell activation. We evaluated i...
- Tumor Necrosis Factor and Interferon-gamma Down-regulate Klotho in Mice With Colitis
[作者:Thurston, RD; Larmonier, CB; Majewski, PM; Ramalingam, R; Midura-Kiela, M; Laubitz, D; Vandewalle, A; Besselsen, DG; Muhlbauer, M; Jobin, C; Kiela, PR; Ghishan, FK,期刊:Gastroenterology, 页码:1384-U231 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Klotho (KL) is an anti-inflammatory protein that protects the endothelium from nitric oxide (NO)-induced dysfunction, reduces the expression of endothelial adhesion molecules, and potentially regulates...
- In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice
[作者:Hunter, MM; Wang, A; Parhar, KS; Johnston, MJG; Van Rooijen, N; Beck, PL; Mckay, DM,期刊:Gastroenterology, 页码:1395-1405 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Infection with the rat tapeworm Hymenolepis diminuta reduces the severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Infection with H diminuta increases colonic expression of argin...
- Epithelial to Mesenchymal Transition Is Impaired in Colon Cancer Cells With Microsatellite Instability
[作者:Pino, MS; Kikuchi, H; Zeng, M; Herraiz, MT; Sperduti, I; Berger, D; Park, DY; Iafrate, AJ; Zukerberg, LR; Chung, DC,期刊:Gastroenterology, 页码:1406-1417 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Colorectal cancers (CRCs) displaying DNA microsatellite instability (MSI) are associated with a favorable natural history, but the molecular basis for this observation has not been defined. We sought t...
- The Mitochondrial Protein hTID-1 Partners With the Caspase-Cleaved Adenomatous Polyposis Cell Tumor Suppressor to Facilitate Apoptosis
[作者:Qian, J; Perchiniak, EM; Sun, K; Groden, J,期刊:Gastroenterology, 页码:1418-1428 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: The adenomatous polyposis cell (APC) tumor suppressor is a multifunctional protein involved in cell migration, proliferation, differentiation, and apoptosis. Cleavage of APC and the subsequent release ...
- Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer
[作者:Mlecnik, B; Tosolini, M; Charoentong, P; Kirilovsky, A; Bindea, G; Berger, A; Camus, M; Gillard, M; Bruneval, P; Fridman, WH; Pages, F; Trajanoski, Z; Galon, J,期刊:Gastroenterology, 页码:1429-1440 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Colorectal cancer is a complex disease involving immune defense mechanisms within the tumor. Herein, we used data integration and biomolecular network reconstruction to generate hypotheses about the me...
- Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas
[作者:Thirlwell, C; Will, OCC; Domingo, E; Graham, TA; McDonald, SAC; Oukrif, D; Jeffrey, R; Gorman, M; Rodriguez-Justo, M; Chin-Aleong, J; Clark, SK; Novelli, MR; Jankowski, JA; Wright, NA; Tomlinson, IPM; Leedham, SJ,期刊:Gastroenterology, 页码:1441-U298 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: According to the somatic mutation theory, monoclonal colorectal lesions arise from sequential mutations in the progeny of a single stem cell. However, studies in a sex chromosome mixoploid mosaic (XO/X...
- Prostaglandin E2 Prevents Helicobacter-Induced Gastric Preneoplasia and Facilitates Persistent Infection in a Mouse Model
[作者:Toller, IM; Hitzler, I; Sayi, A; Mueller, A,期刊:Gastroenterology, 页码:1455-U315 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Persistent infection with the human pathogen Helicobacter pylori increases the risk of gastric cancer. In this study, we investigated the role of cyclooxygenase-2 (COX-2) and its main product, prostagl...
- Lack of Retinoic Acid Leads to Increased Langerin-Expressing Dendritic Cells in Gut-Associated Lymphoid Tissues
[作者:Chang, SY; Cha, HR; Chang, JH; Ko, HJ; Yang, H; Malissen, B; Iwata, M; Kweon, MN,期刊:Gastroenterology, 页码:1468-U332 , 文章类型: Article,,卷期:2010年138-4]
- BACKGROUND & AIMS: Retinoic acid (RA) is a crucial factor for maintaining homeostasis in the gut, including lymphocyte homing, immunoglobulin (Ig) A production, and T regulatory cells (Treg) and T helper cell 17 (T(H)17)...
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