- Crystal Structure and Functional Analysis of Homocitrate Synthase, an Essential Enzyme in Lysine Biosynthesis
[作者:Bulfer, SL; Scott, EM; Couture, JF; Pillus, L; Trievel, RC,期刊:Journal of Biological Chemistry, 页码:35769-35780 , 文章类型: Article,,卷期:2009年284-51]
- Homocitrate synthase (HCS) catalyzes the first and committed step in lysine biosynthesis in many fungi and certain Archaea and is a potential target for antifungal drugs. Here we report the crystal structure of the HCS a...
- STRA8 Shuttles between Nucleus and Cytoplasm and Displays Transcriptional Activity
[作者:Tedesco, M; La Sala, G; Barbagallo, F; De Felici, M; Farini, D,期刊:Journal of Biological Chemistry, 页码:35781-35793 , 文章类型: Article,,卷期:2009年284-51]
- Stra8 (stimulated by retinoic acid 8) encodes a protein crucial for mammalian germ cells entering into premeiotic stages. Here, to elucidate the still unknown STRA8 molecular functions, we studied the cellular localizati...
- Fatty Acid- and Retinoid-binding Proteins Have Distinct Binding Pockets for the Two Types of Cargo
[作者:Jordanova, R; Groves, MR; Kostova, E; Woltersdorf, C; Liebau, E; Tucker, PA,期刊:Journal of Biological Chemistry, 页码:35818-35826 , 文章类型: Article,,卷期:2009年284-51]
- Parasitic nematodes cause serious diseases in humans, animals, and plants. They have limited lipid metabolism and are reliant on lipid-binding proteins to acquire these metabolites from their hosts. Several structurally ...
- Differential Effects of Lysophosphatidic Acid and Phosphatidylinositol 4,5-Bisphosphate on Actin Dynamics by Direct Association with the Actin-binding Protein Villin
[作者:Tomar, A; George, SP; Mathew, S; Khurana, S,期刊:Journal of Biological Chemistry, 页码:35278-35282 , 文章类型: Article,,卷期:2009年284-51]
- We have previously reported that the epithelial cell-specific actin-binding protein villin directly associates with phosphatidylinositol 4,5-bisphosphate (PIP2) through three binding sites that overlap with actin-binding...
- Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation
[作者:Martinez, GJ; Zhang, ZM; Chung, Y; Reynolds, JM; Lin, X; Jetten, AM; Feng, XH; Dong, C,期刊:Journal of Biological Chemistry, 页码:35283-35286 , 文章类型: Article,,卷期:2009年284-51]
- Transforming growth factor beta (TGF-beta) is a crucial cytokine with pleiotropic functions on immune cells. In CD4(+) T cells, TGF-beta is required for induction of both regulatory T and Th17 cells. However, the molecul...
- Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade
[作者:Ng, SS; Mahmoudi, T; Danenberg, E; Bejaoui, I; de Lau, W; Korswagen, HC; Schutte, M; Clevers, H,期刊:Journal of Biological Chemistry, 页码:35308-35313 , 文章类型: Article,,卷期:2009年284-51]
- Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon cancer. Because GSK3 is a key componen...
- Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction
[作者:Zhang, T; Li, YY; Yu, YK; Zou, P; Jiang, YQ; Sun, DX,期刊:Journal of Biological Chemistry, 页码:35381-35389 , 文章类型: Article,,卷期:2009年284-51]
- The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer. The loading of protein kinases to Hsp90 is actively mediated ...
- Human IgG1 Hinge Fragmentation as the Result of H2O2-mediated Radical Cleavage
[作者:Yan, BX; Yates, Z; Balland, A; Kleemann, GR,期刊:Journal of Biological Chemistry, 页码:35390-35402 , 文章类型: Article,,卷期:2009年284-51]
- Hinge cleavage of a recombinant human IgG1 antibody, generated during production in a Chinese hamster ovary cell culture, was observed in the purified material. The cleavage products could be reproduced by incubation of ...
- Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway ACTIVATION IN RESPONSE TO CADMIUM
[作者:Polge, C; Jaquinod, M; Holzer, F; Bourguignon, J; Walling, L; Brouquisse, R,期刊:Journal of Biological Chemistry, 页码:35412-35424 , 文章类型: Article,,卷期:2009年284-51]
- Heavy metals are known to generate reactive oxygen species that lead to the oxidation and fragmentation of proteins, which become toxic when accumulated in the cell. In this study, we investigated the role of the proteas...
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