- Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
[作者:Carson, JL; Terrin, ML; Noveck, H; Sanders, DW; Chaitman, BR; Rhoads, GG; Nemo, G; Dragert, K; Beaupre, L; Hildebrand, K; Macaulay, W; Lewis, C; Cook, DR; Dobbin, G; Zakriya, KJ; Apple, FS; Horney, RA; Magaziner, J,期刊:New England Journal of Medicine, 页码:2453-2462 , 文章类型: Article,,卷期:2011年365-26]
- BACKGROUNDThe hemoglobin threshold at which postoperative red-cell transfusion is warranted is controversial. We conducted a randomized trial to determine whether a higher threshold for blood transfusion would improve re...
- Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients
[作者:Kakkar, AK; Cimminiello, C; Goldhaber, SZ; Parakh, R; Wang, C; Bergmann, JF,期刊:New England Journal of Medicine, 页码:2463-2472 , 文章类型: Article,,卷期:2011年365-26]
- BACKGROUNDAlthough thromboprophylaxis reduces the incidence of venous thromboembolism in acutely ill medical patients, an associated reduction in the rate of death from any cause has not been shown.METHODSWe conducted a ...
- Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer
[作者:Burger, RA; Brady, MF; Bookman, MA; Fleming, GF; Monk, BJ; Huang, H; Mannel, RS; Homesley, HD; Fowler, J; Greer, BE; Boente, M; Birrer, MJ; Liang, SX,期刊:New England Journal of Medicine, 页码:2473-2483 , 文章类型: Article,,卷期:2011年365-26]
- BACKGROUNDVascular endothelial growth factor is a key promoter of angiogenesis and disease progression in epithelial ovarian cancer. Bevacizumab, a humanized anti-vascular endothelial growth factor monoclonal antibody, h...
- A Phase 3 Trial of Bevacizumab in Ovarian Cancer
[作者:Perren, TJ; Swart, AM; Pfisterer, J; Ledermann, JA; Pujade-Lauraine, E; Kristensen, G; Carey, MS; Beale, P; Cervantes, A; Kurzeder, C; du Bois, A; Sehouli, J; Kimmig, R; Stahle, A; Collinson, F; Essapen, S; Gourley, C; Lortholary, A; Selle, F; Mirza, MR; Leminen, A; Plante, M; Stark, D; Qian, WD; Parmar, MKB; Oza, AM,期刊:New England Journal of Medicine, 页码:2484-2496 , 文章类型: Article,,卷期:2011年365-26]
- BACKGROUNDAngiogenesis plays a role in the biology of ovarian cancer. We examined the effect of bevacizumab, the vascular endothelial growth factor inhibitor, on survival in women with this disease.METHODSWe randomly ass...
- SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
[作者:Wang, LL; Lawrence, MS; Wan, YZ; Stojanov, P; Sougnez, C; Stevenson, K; Werner, L; Sivachenko, A; DeLuca, DS; Zhang, L; Zhang, WD; Vartanov, AR; Fernandes, SM; Goldstein, NR; Folco, EG; Cibulskis, K; Tesar, B; Sievers, QL; Shefler, E; Gabriel, S; Hacohen, N; Reed, R; Meyerson, M; Golub, TR; Lander, ES; Neuberg, D; Brown, JR; Getz, G; Wu, CJ,期刊:New England Journal of Medicine, 页码:2497-2506 , 文章类型: Article,,卷期:2011年365-26]
- BACKGROUNDThe somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood.METHODS We obtained DNA samples from leukemia cells in 91...
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