- Natural Killer Cell Education and Tolerance
[作者：Orr, MT; Lanier, LL,期刊：Cell, 页码：847-856 , 文章类型： Review，,卷期：2010年142-6]
- Natural killer (NK) cells play a key role in the immune response to certain infections and malignancies by direct cytolysis of infected or transformed cells and by secretion of potent immune mediators. NK cells express a...
- Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
[作者：Duce, JA; Tsatsanis, A; Cater, MA; James, SA; Robb, E; Wikhe, K; Leong, SL; Perez, K; Johanssen, T; Greenough, MA; Cho, HH; Galatis, D; Moir, RD; Masters, CL; McLean, C; Tanzi, RE; Cappai, R; Barnham, KJ; Ciccotosto, GD; Rogers, JT; Bush, AI,期刊：Cell, 页码：857-867 , 文章类型： Article，,卷期：2010年142-6]
- Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe2+ elevation as well as extracellular Zn2+ accumulation within amyloid plaque. We found that the AD beta-amyloid protein precursor (APP) possesses fe...
- Switch between Large Hand-Over-Hand and Small Inchworm-like Steps in Myosin VI
[作者：Nishikawa, S; Arimoto, I; Ikezaki, K; Sugawa, M; Ueno, H; Komori, T; Iwane, AH; Yanagida, T,期刊：Cell, 页码：879-888 , 文章类型： Article，,卷期：2010年142-6]
- Many biological motor molecules move within cells using stepsizes predictable from their structures. Myosin VI, however, has much larger and more broadly distributed stepsizes than those predicted from its short lever ar...
- Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
[作者：Montessuit, S; Somasekharan, SP; Terrones, O; Lucken-Ardjomande, S; Herzig, S; Schwarzenbacher, R; Manstein, DJ; Bossy-Wetzel, E; Basanez, G; Meda, P; Martinou, JC,期刊：Cell, 页码：889-901 , 文章类型： Article，,卷期：2010年142-6]
- In response to many apoptotic stimuli, oligomerization of Bax is essential for mitochondrial outer membrane permeabilization and the ensuing release of cytochrome c. These events are accompanied by mitochondrial fission ...
- Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
[作者：Lu, LF; Boldin, MP; Chaudhry, A; Lin, LL; Taganov, KD; Hanada, T; Yoshimura, A; Baltimore, D; Rudensky, AY,期刊：Cell, 页码：914-929 , 文章类型： Article，,卷期：2010年142-6]
- Foxp3(+) regulatory T (Treg) cells maintain immune homeostasis by limiting different types of inflammatory responses. Here, we report that miR-146a, one of the miRNAs prevalently expressed in Treg cells, is critical for ...
- DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC
[作者：Rai, K; Sarkar, S; Broadbent, TJ; Voas, M; Grossmann, KF; Nadauld, LD; Dehghanizadeh, S; Hagos, FT; Li, YM; Toth, RK; Chidester, S; Bahr, TM; Johnson, WE; Sklow, B; Burt, R; Cairns, BR; Jones, DA,期刊：Cell, 页码：930-942 , 文章类型： Article，,卷期：2010年142-6]
- Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylas...
- Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding
[作者：Asher, G; Reinke, H; Altmeyer, M; Gutierrez-Arcelus, M; Hottiger, MO; Schibler, U,期刊：Cell, 页码：943-953 , 文章类型： Article，,卷期：2010年142-6]
- Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are largely unknown. Here we show that in l...
- Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
[作者：Vermeulen, M; Eberl, HC; Matarese, F; Marks, H; Denissov, S; Butter, F; Lee, KK; Olsen, JV; Hyman, AA; Stunnenberg, HG; Mann, M,期刊：Cell, 页码：967-980 , 文章类型： Article，,卷期：2010年142-6]
- Trimethyl-lysine (me3) modifications on histones are the most stable epigenetic marks and they control chromatin-mediated regulation of gene expression. Here, we determine proteins that bind these marks by high-accuracy,...
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