- Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands
[作者:Denis, C; Sauliere, A; Galandrin, S; Senard, JM; Gales, C,期刊:Current Pharmaceutical Design, 页码:128-144 , 文章类型: Review,,卷期:2012年18-2]
- Cell surface G protein-coupled receptors (GPCRs) drive numerous signaling pathways involved in the regulation of a broad range of physiologic processes. Today, they represent the largest target for modern drugs developme...
- The Plasticity of the 7TMR Signaling Machinery and the Search for Pharmacological Selectivity
[作者:Flordellis, CS,期刊:Current Pharmaceutical Design, 页码:145-160 , 文章类型: Review,,卷期:2012年18-2]
- Components of 7TMR signaling machinery once considered as rigid, fixed and inflexible entities, operating in a one-dimensional way, homogeneous spatially and temporally, are now proved to be structurally plastic, flexibl...
- The Multiple Layers of Signaling Selectivity at Protease-Activated Receptors
[作者:Kyriazis, I; Ellul, J; Katsakiori, P; Panayiotakopoulos, G; Flordellis, C,期刊:Current Pharmaceutical Design, 页码:161-174 , 文章类型: Review,,卷期:2012年18-2]
- The Protease-Activated Receptors (PARs) are G-protein-coupled receptors (GPCRs) characterized by a unique mechanism of activation. They carry built in their extended N-terminal structure their own activating agonist, in ...
- Current Treatment Strategies for Multiple Sclerosis - Efficacy Versus Neurological Adverse Effects
[作者:Weber, MS; Menge, T; Lehmann-Horn, K; Kronsbein, HC; Zettl, U; Sellner, J; Hemmer, B; Stuve, O,期刊:Current Pharmaceutical Design, 页码:209-219 , 文章类型: Review,,卷期:2012年18-2]
- Recent years have broadened the spectrum of therapeutic strategies and specific agents for treatment of multiple sclerosis (MS). While immune-modulating drugs remain the first-line agents for MS predominantly due to thei...
- Enkephalin Degrading Enzymes: Metalloproteases with High Potential for Drug Development
[作者:Khaket, TP; Singh, J; Attri, P; Dhanda, S,期刊:Current Pharmaceutical Design, 页码:220-230 , 文章类型: Review,,卷期:2012年18-2]
- Enkephalins play a great role in management of pain, blood pressure, hypertension and cardiovascular diseases. Enkephalins are short-lived molecules being rapidly hydrolyzed following their synaptic release by enkephalin...
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