- HDAC1, a novel marker for benign teratomas
[作者：Simboeck, E; Di Croce, L,期刊：EMBO journal, 页码：3893-3895 , 文章类型： Article，,卷期：2010年29-23]
- Histone deacetylases (HDACs) are non-redundant chromatin-modifying enzymes that are critical cellular regulators and are often overexpressed in cancers. Targeting them by HDAC inhibitors (HDACis) can induce growth arrest...
- Direct observation of stepped proteolipid ring rotation in E. coli FoF1-ATP synthase
[作者：Ishmukhametov, R; Hornung, T; Spetzler, D; Frasch, WD,期刊：EMBO journal, 页码：3911-3923 , 文章类型： Article，,卷期：2010年29-23]
- Although single-molecule experiments have provided mechanistic insight for several molecular motors, these approaches have proved difficult for membrane bound molecular motors like the FoF1-ATP synthase, in which proton ...
- Multiple C-terminal tail Ca2+/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization
[作者：Kim, EY; Rumpf, CH; Van Petegem, F; Arant, RJ; Findeisen, F; Cooley, ES; Isacoff, EY; Minor, DL,期刊：EMBO journal, 页码：3924-3938 , 文章类型： Article，,卷期：2010年29-23]
- Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca-V function. In this study, we report the structure of a Ca2+/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ heli...
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
[作者：Oh, WJ; Wu, CC; Kim, SJ; Facchinetti, V; Julien, LA; Finlan, M; Roux, PP; Su, B; Jacinto, E,期刊：EMBO journal, 页码：3939-3951 , 文章类型： Article，,卷期：2010年29-23]
- The mechanisms that couple translation and protein processing are poorly understood in higher eukaryotes. Although mammalian target of rapamycin (mTOR) complex 1 (mTORC1) controls translation initiation, the function of ...
- Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme
[作者：Ren, M; Guo, Q; Guo, LA; Lenz, M; Qian, F; Koenen, RR; Xu, H; Schilling, AB; Weber, C; Ye, RD; Dinner, AR; Tang, WJ,期刊：EMBO journal, 页码：3952-3966 , 文章类型： Article，,卷期：2010年29-23]
- Macrophage inflammatory protein-1 (MIP-1), MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1 alpha and MIP-1 beta form high-molecular-weig...
- A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes
[作者：Varier, RA; Outchkourov, NS; de Graaf, P; van Schaik, FMA; Ensing, HJL; Wang, FW; Higgins, JMG; Kops, GJPL; Timmers, HTM,期刊：EMBO journal, 页码：3967-3978 , 文章类型： Article，,卷期：2010年29-23]
- Histone methylation patterns are correlated with eukaryotic gene transcription. High-affinity binding of the plant homeodomain (PHD) of TFIID subunit TAF3 to trimethylated lysine-4 of histone H3 (H3K4me3) is involved in ...
- The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26
[作者：Diebold, ML; Koch, M; Loeliger, E; Cura, V; Winston, F; Cavarelli, J; Romier, C,期刊：EMBO journal, 页码：3979-3991 , 文章类型： Article，,卷期：2010年29-23]
- Binding of elongation factor Spt6 to Iws1 provides an effective means for coupling eukaryotic mRNA synthesis, chromatin remodelling and mRNA export. We show that an N-terminal region of Spt6 (Spt6N) is responsible for in...
- Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans
[作者：Lagger, S; Meunier, D; Mikula, M; Brunmeir, R; Schlederer, M; Artaker, M; Pusch, O; Egger, G; Hagelkruys, A; Mikulits, W; Weitzer, G; Muellner, EW; Susani, M; Kenner, L; Seiser, C,期刊：EMBO journal, 页码：3992-4007 , 文章类型： Article，,卷期：2010年29-23]
- Histone deacetylase (HDAC) inhibitors induce cell cycle arrest, differentiation or apoptosis in tumour cells and are, therefore, promising anti-cancer reagents. However, the specific HDAC isoforms that mediate these effe...
- Adhesion shapes T cells for prompt and sustained T-cell receptor signalling
[作者：Contento, RL; Campello, S; Trovato, AE; Magrini, E; Anselmi, F; Viola, A,期刊：EMBO journal, 页码：4035-4047 , 文章类型： Article，,卷期：2010年29-23]
- During T-cell migration, cell polarity is orchestrated by chemokine receptors and adhesion molecules and involves the functional redistribution of molecules and organelles towards specific cell compartments. In contrast,...
- Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch
[作者：Muto, A; Ochiai, K; Kimura, Y; Itoh-Nakadai, A; Calame, KL; Ikebe, D; Tashiro, S; Igarashi, K,期刊：EMBO journal, 页码：4048-4061 , 文章类型： Article，,卷期：2010年29-23]
Two transcription factors, Pax5 and Blimp-1, form a gene regulatory network (GRN) with a double-negative loop, which defines either B-cell (Pax5 high) or plasma cell (Blimp-1 high) status as a binary switch. However, ...
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