- Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis
[作者：Norberg, E; Karlsson, M; Korenovska, O; Szydlowski, S; Silberberg, G; Uhlen, P; Orrenius, S; Zhivotovsky, B,期刊：EMBO journal, 页码：3869-3878 , 文章类型： Article，,卷期：2010年29-22]
Cellular calcium uptake is a controlled physiological process mediated by multiple ion channels. The exposure of cells to either one of the protein kinase C (PKC) inhibitors, staurosporine (STS) or PKC412, can trigger...
- Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication
[作者：Liao, TL; Wu, CY; Su, WC; Jeng, KS; Lai, MMC,期刊：EMBO journal, 页码：3879-3890 , 文章类型： Article，,卷期：2010年29-22]
- Influenza A virus RNA replication requires an intricate regulatory network involving viral and cellular proteins. In this study, we examined the roles of cellular ubiquitinating/ deubiquitinating enzymes (DUBs). We obser...
- Let's see how tmRNA rescues a stuck ribosome
[作者：Klaholz, BP,期刊：EMBO journal, 页码：3747-3749 , 文章类型： Editorial Material，,卷期：2010年29-22]
- In the current issue, Weis et al (2010a) and Fu et al (2010) provide cryo-electron microscopy snapshots of different states of the bacterial ribosome-rescuing complex with tmRNA. This regulatory RNA molecule remarkably c...
- The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions
[作者：Ritterhoff, S; Farah, CM; Grabitzki, J; Lochnit, G; Skurat, AV; Schmitz, ML,期刊：EMBO journal, 页码：3750-3761 , 文章类型： Article，,卷期：2010年29-22]
- Protein kinases are organized in hierarchical networks that are assembled and regulated by scaffold proteins. Here, we identify the evolutionary conserved WD40-repeat protein Han11 as an interactor of the kinase homeodom...
- Conformational flexibility of RNA polymerase III during transcriptional elongation
[作者：Fernandez-Tornero, C; Bottcher, B; Rashid, UJ; Steuerwald, U; Florchinger, B; Devos, DP; Lindner, D; Muller, CW,期刊：EMBO journal, 页码：3762-3772 , 文章类型： Article，,卷期：2010年29-22]
- RNA polymerase (Pol) III is responsible for the transcription of genes encoding small RNAs, including tRNA, 5S rRNA and U6 RNA. Here, we report the electron cryomicroscopy structures of yeast Pol III at 9.9 angstrom reso...
- Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
[作者：Yan, S; Sun, XX; Xiang, BG; Cang, H; Kang, XL; Chen, YY; Li, H; Shi, GY; Yeh, ETH; Wang, BL; Wang, XR; Yi, J,期刊：EMBO journal, 页码：3773-3786 , 文章类型： Article，,卷期：2010年29-22]
- The molecular chaperone heat shock protein 90 (Hsp90) and the co-chaperone/ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) control the turnover of client proteins. How this system decides to stabil...
- Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
[作者：Park, SY; Kim, HS; Kim, NH; Ji, S; Cha, SY; Kang, JG; Ota, I; Shimada, K; Konishi, N; Nam, HW; Hong, SW; Yang, WH; Roth, J; Yook, JI; Cho, JW,期刊：EMBO journal, 页码：3787-3796 , 文章类型： Article，,卷期：2010年29-22]
- Protein O-phosphorylation often occurs reciprocally with O-GlcNAc modification and represents a regulatory principle for proteins. O-phosphorylation of serine by glycogen synthase kinase-3 beta on Snail1, a transcription...
- The structural basis for catalysis and substrate specificity of a rhomboid protease
[作者：Vinothkumar, KR; Strisovsky, K; Andreeva, A; Christova, Y; Verhelst, S; Freeman, M,期刊：EMBO journal, 页码：3797-3809 , 文章类型： Article，,卷期：2010年29-22]
- Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular s...
- tmRNA-SmpB: a journey to the centre of the bacterial ribosome
[作者：Weis, F; Bron, P; Giudice, E; Rolland, JP; Thomas, D; Felden, B; Gillet, R,期刊：EMBO journal, 页码：3810-3818 , 文章类型： Article，,卷期：2010年29-22]
- Ribosomes mediate protein synthesis by decoding the information carried by messenger RNAs (mRNAs) and catalysing peptide bond formation between amino acids. When bacterial ribosomes stall on incomplete messages, the tran...
- Visualizing the transfer-messenger RNA as the ribosome resumes translation
[作者：Fu, J; Hashem, Y; Wower, I; Lei, JL; Liao, HY; Zwieb, C; Wower, J; Frank, J,期刊：EMBO journal, 页码：3819-3825 , 文章类型： Article，,卷期：2010年29-22]
- Bacterial ribosomes stalled by truncated mRNAs are rescued by transfer-messenger RNA (tmRNA), a dual-function molecule that contains a tRNA-like domain (TLD) and an internal open reading frame (ORF). Occupying the empty ...
- 5 '-Single-stranded/duplex DNA junctions are loading sites for E. coli UvrD translocase
[作者：Tomko, EJ; Jia, HF; Park, J; Maluf, NK; Ha, T; Lohman, TM,期刊：EMBO journal, 页码：3826-3839 , 文章类型： Article，,卷期：2010年29-22]
- Escherichia coli UvrD is a 3'-5' superfamily 1A helicase/translocase involved in a variety of DNA metabolic processes. UvrD can function either as a helicase or only as an single-stranded DNA (ssDNA) translocase. The swi...
- DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans
[作者：Hickman, AB; James, JA; Barabas, O; Pasternak, C; Ton-Hoang, B; Chandler, M; Sommer, S; Dyda, F,期刊：EMBO journal, 页码：3840-3852 , 文章类型： Article，,卷期：2010年29-22]
- Bacterial insertion sequences (ISs) from the IS200/IS605 family encode the smallest known DNA transposases and mobilize through single-stranded DNA transposition. Transposition by one particular family member, ISDra2 fro...
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