- The more, the better: the BICD family gets bigger
[作者：Terenzio, M; Schiavo, G,期刊：EMBO journal, 页码：1625-1626 , 文章类型： Article，,卷期：2010年29-10]
- Balancing the flow of organelles and molecular complexes to and from the cell periphery is very important, and this is especially true for neurons, which are an extreme example of polarised cells. Neurons need to precise...
- Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
[作者：Schlager, MA; Kapitein, LC; Grigoriev, I; Burzynski, GM; Wulf, PS; Keijzer, N; de Graaff, E; Fukuda, M; Shepherd, IT; Akhmanova, A; Hoogenraad, CC,期刊：EMBO journal, 页码：1637-1651 , 文章类型： Article，,卷期：2010年29-10]
- Membrane and secretory trafficking are essential for proper neuronal development. However, the molecular mechanisms that organize secretory trafficking are poorly understood. Here, we identify Bicaudal-D-related protein ...
- Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion
[作者：Krull, S; Dorries, J; Boysen, B; Reidenbach, S; Magnius, L; Norder, H; Thyberg, J; Cordes, VC,期刊：EMBO journal, 页码：1659-1673 , 文章类型： Article，,卷期：2010年29-10]
- Amassments of heterochromatin in somatic cells occur in close contact with the nuclear envelope (NE) but are gapped by channel- and cone-like zones that appear largely free of heterochromatin and associated with the nucl...
- Nuclear deadenylation/polyadenylation factors regulate 3 ' processing in response to DNA damage
[作者：Cevher, MA; Zhang, XK; Fernandez, S; Kim, S; Baquero, J; Nilsson, P; Lee, S; Virtanen, A; Kleiman, FE,期刊：EMBO journal, 页码：1674-1687 , 文章类型： Article，,卷期：2010年29-10]
- We previously showed that mRNA 3' end cleavage reaction in cell extracts is strongly but transiently inhibited under DNA-damaging conditions. The cleavage stimulation factor-50 (CstF-50) has a role in this response, prov...
- The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing
[作者：Herranz, H; Hong, X; Perez, L; Ferreira, A; Olivieri, D; Cohen, SM; Milan, M,期刊：EMBO journal, 页码：1688-1698 , 文章类型： Article，,卷期：2010年29-10]
- MicroRNAs (miRNAs) have been implicated in cell-cycle regulation and in some cases shown to have a role in tissue growth control. Depletion of miRNAs was found to have an effect on tissue growth rates in the wing primord...
- Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress
[作者：Zhang, LY; Park, CH; Wu, J; Kim, H; Liu, WJ; Fujita, T; Balasubramani, M; Schreiber, EM; Wang, XF; Wan, Y,期刊：EMBO journal, 页码：1726-1737 , 文章类型： Article，,卷期：2010年29-10]
- Recent studies have shown a critical function for the ubiquitin-proteasome system (UPS) in regulating the signalling network for DNA damage responses and DNA repair. To search for new UPS targets in the DNA damage signal...
- Replication through an abasic DNA lesion: structural basis for adenine selectivity
[作者：Obeid, S; Blatter, N; Kranaster, R; Schnur, A; Diederichs, K; Welte, W; Marx, A,期刊：EMBO journal, 页码：1738-1747 , 文章类型： Article，,卷期：2010年29-10]
- Abasic sites represent the most frequent DNA lesions in the genome that have high mutagenic potential and lead to mutations commonly found in human cancers. Although these lesions are devoid of the genetic information, a...
- The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
[作者：Lee, YR; Yuan, WC; Ho, HC; Chen, CH; Shih, HM; Chen, RH,期刊：EMBO journal, 页码：1748-1761 , 文章类型： Article，,卷期：2010年29-10]
- Death-associated protein kinase (DAPK) was identified as a mediator of interferon (IFN)-induced cell death. How IFN controls DAPK activation remains largely unknown. Here, we identify the BTB-Kelch protein KLHL20 as a ne...
- Viral apoptosis is induced by IRF-3-mediated activation of Bax
[作者：Chattopadhyay, S; Marques, JT; Yamashita, M; Peters, KL; Smith, K; Desai, A; Williams, BRG; Sen, GC,期刊：EMBO journal, 页码：1762-1773 , 文章类型： Article，,卷期：2010年29-10]
Upon infection with many RNA viruses, the cytoplasmic retinoic acid inducible gene-I (RIG-I) pathway activates the latent transcription factor IRF-3, causing its nuclear translocation and the induction of many antivir...
- Mitochondrial fission and remodelling contributes to muscle atrophy
[作者：Romanello, V; Guadagnin, E; Gomes, L; Roder, I; Sandri, C; Petersen, Y; Milan, G; Masiero, E; Del Piccolo, P; Foretz, M; Scorrano, L; Rudolf, R; Sandri, M,期刊：EMBO journal, 页码：1774-1785 , 文章类型： Article，,卷期：2010年29-10]
- Mitochondria are crucial organelles in the production of energy and in the control of signalling cascades. A machinery of pro-fusion and fission proteins regulates their morphology and subcellular localization. In muscle...
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