- How do tumours adapt to nutrient stress?
[作者：Wek, RC; Staschke, KA,期刊：EMBO journal, 页码：1946-1947 , 文章类型： Article，,卷期：2010年29-12]
- Reduced blood flow contributes to tumour hypoxia and nutrient deprivation forcing cancer cells to adapt to ensure survival. In this issue of The EMBO Journal, Ye et al show that a stress response pathway including the eI...
- Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway
[作者：Khandelwal, P; Ruiz, WG; Apodaca, G,期刊：EMBO journal, 页码：1961-1975 , 文章类型： Article，,卷期：2010年29-12]
- Compensatory endocytosis (CE) ensures recycling of membrane components and maintenance of plasma membrane size; however, the mechanisms, regulation, and physiological functions of clathrin-independent modes of CE are poo...
- A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4
[作者：Osman, C; Haag, M; Wieland, FT; Brugger, B; Langer, T,期刊：EMBO journal, 页码：1976-1987 , 文章类型： Article，,卷期：2010年29-12]
Cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes, has pivotal functions for the cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic...
- Essential role of p18(Hamlet)/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation
[作者：Cuadrado, A; Corrado, N; Perdiguero, E; Lafarga, V; Munoz-Canoves, P; Nebreda, AR,期刊：EMBO journal, 页码：2014-2025 , 文章类型： Article，,卷期：2010年29-12]
- The chromatin-remodelling complex SNF2-related CBP activator protein (SRCAP) regulates chromatin structure in yeast by modulating the exchange of histone H2A for the H2A.Z variant. Here, we have investigated the contribu...
- Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome
[作者：Li, DY; Li, H; Wang, T; Pan, H; Lin, G; Li, HL,期刊：EMBO journal, 页码：2037-2047 , 文章类型： Article，,卷期：2010年29-12]
- Mycobacterium tuberculosis (Mtb) possesses a proteasome system analogous to the eukaryotic ubiquitin-proteasome pathway. Mtb requires the proteasome to resist killing by the host immune system. The detailed assembly proc...
- Rad8(Rad5)/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast
[作者：Coulon, S; Ramasubramanyan, S; Alies, C; Philippin, G; Lehmann, A; Fuchs, RP,期刊：EMBO journal, 页码：2048-2058 , 文章类型： Article，,卷期：2010年29-12]
- Many DNA lesions cause pausing of replication forks at lesion sites; thus, generating gaps in the daughter strands that are filled-in by post-replication repair (PRR) pathways. In Saccharomyces cerevisiae, PRR involves t...
- Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4
[作者：Wong, JHY; Brown, JA; Suo, Z; Blum, P; Nohmi, T; Ling, H,期刊：EMBO journal, 页码：2059-2069 , 文章类型： Article，,卷期：2010年29-12]
- Y-family DNA polymerases bypass Pt-GG, the cisplatin-DNA double-base lesion, contributing to the cisplatin resistance in tumour cells. To reveal the mechanism, we determined three structures of the Y-family DNA polymeras...
- CaMKII alpha interacts with M4 muscarinic receptors to control receptor and psychomotor function
[作者：Guo, ML; Fibuch, EE; Liu, XY; Choe, ES; Buch, S; Mao, LM; Wang, JQ,期刊：EMBO journal, 页码：2070-2081 , 文章类型： Article，,卷期：2010年29-12]
- Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the mammalian brain and are essential for neuronal functions. These receptors are believed to be actively regulated by intracellular signals, although t...
- The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
[作者：Ye, JB; Kumanova, M; Hart, LS; Sloane, K; Zhang, HY; De Panis, DN; Bobrovnikova-Marjon, E; Diehl, JA; Ron, D; Koumenis, C,期刊：EMBO journal, 页码：2082-2096 , 文章类型： Article，,卷期：2010年29-12]
- The transcription factor ATF4 regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses, and it is overexpressed in human solid tumours, suggesting that it has an impo...
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