- Conformational ensembles, signal transduction and residue hot spots: Application to drug discovery
[作者:Ozbabacan, SEA; Gursoy, A; Keskin, O; Nussinov, R,期刊:Current Opinion in Drug Discovery & Development, 页码:527-537 , 文章类型: Review,,卷期:2010年13-5]
- A key step in drug development is the identification of both a protein target and its topological cellular network location and interactions, with regard to information flow in disease-causing events and to medication ef...
- Current understanding and importance of histone phosphorylation in regulating chromatin biology
[作者:Perez-Cadahia, B; Drobic, B; Khan, P; Shivashankar, CC; Davie, JR,期刊:Current Opinion in Drug Discovery & Development, 页码:613-622 , 文章类型: Review,,卷期:2010年13-5]
- The core histones H2A, H2B, H3 and H4, undergo various post-translational modifications, such as acetylation, methylation and phosphorylation. Core histone phosphorylation has roles in several biological responses, inclu...
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