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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共32条记录   Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatly acid oxidation in moderately obese men [作者：Riserus, U; Sprecher, D; Johnson, T; Olson, E; Hirschberg, S; Liu, A; Fang, Z; Hegde, P; Richards, D; Sarov-Blat, L; Strum, JC; Basu, S; Cheeseman, J; Fielding, BA; Humphreys, SM; Danoff, T; Moore, NR; Murgatroyd, P; O'Rahilly, S; Sutton, P; Willson, T; Hassall, D; Frayn, KN; Karpe, F,期刊：Diabetes, 页码：332-339 , 文章类型： Article，,卷期：2008年57-2] OBJECTIEVE-Pharmacological use of peroxisome proliferator-activated receptor (PPAR)delta agonists and transgenic overexpression of PPAR delta in mice suggest amelioration of features of the metabolic syndrome through enh... Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism [作者：Santos, SHS; Fernandes, LR; Mario, EG; Ferreira, AM; Porto, LJ; Alvarez-Leite, J; Botion, L; Bader, M; Alenina, N; Santos, RS,期刊：Diabetes, 页码：340-347 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Metabolic syndrome is characterized by the variable coexistence of obesity, hyperinsulinemia, insulin resistance, dyslipidemia, and hypertension. It is well known that angiotensin (Ang) II is importantly involv... Fas-associated death receptor signaling evoked by human amylin in islet beta-cells [作者：Zhang, SP; Liu, H; Yu, H; Cooper, GJS,期刊：Diabetes, 页码：348-356 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Aggregation of human amylin (hA) into beta-sheet-containing oligomers is linked to islet beta-cell dysfunction and the pathogenesis of type 2 diabetes. Here, we investigated possible contributions of Fas-associ... Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the cohen diabetic rat [作者：Weksler-Zangen, S; Raz, I; Lenzen, S; Jorns, A; Ehrenfeld, S; Amir, G; Oprescu, A; Yagil, Y; Yagil, C; Zangen, DH; Kaiser, N,期刊：Diabetes, 页码：279-287 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-The Cohen diabetes-sensitive rat develops postprandial hyperglycemia when fed a high-sucrose, copper-poor diet, whereas the Cohen diabetes-resistant rat maintains normoglycemia. The pathophysiological basis of ... Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment [作者：Hojlund, K; Glintborg, D; Andersen, NR; Birk, JB; Treebak, JT; Frosig, C; Beck-Nielsen, H; Wojtaszewski, JFP,期刊：Diabetes, 页码：357-366 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Insulin resistance in skeletal muscle is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (PCOS). However, the molecular mechanisms underlying skeletal muscle insulin resistance a... Insulin action in the double incretin receptor knockout mouse [作者：Ayala, JE; Bracy, DP; Hansotia, T; Flock, G; Seino, Y; Wasserman, DH; Drucker, DJ,期刊：Diabetes, 页码：288-297 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-The incretins glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide have been postulated to play a role in regulating insulin action, although the mechanisms behind this relationship remain o... High visceral and low abdominal subcutaneous fat stores in the obese adolescent - A determinant of an adverse metabolic phenotype [作者：Taksali, SE; Caprio, S; Dziura, J; Dufour, S; Cali, AMG; Goodman, TR; Papademetris, X; Burgert, TS; Pierpont, BM; Savoye, M; Shaw, M; Seyal, AA; Weiss, R,期刊：Diabetes, 页码：367-371 , 文章类型： Article，,卷期：2008年57-2] OBJECTYVE-To explore whether an imbalance between the visceral and subcutaneous fat. depots and a corresponding dysregulation of the adipokine milieu is associated with excessive accumulation of fat in the liver and musc... 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age [作者：Hypponen, E; Boucher, BJ; Berry, DJ; Power, C,期刊：Diabetes, 页码：298-305 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Hypovitarninosis D and reduced IGF-1 are associated, individually, with metabolic syndrome. Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their comb... Serum vaspin concentrations in human obesity and type 2 diabetes [作者：You, BS; Kloting, N; Kratzsch, J; Lee, N; Park, JW; Song, ES; Ruschke, K; Oberbach, A; Fasshauer, M; Stumvoll, M; Bluher, M,期刊：Diabetes, 页码：372-377 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA ex... Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP [作者：Kim, YD; Park, KG; Lee, YS; Park, YY; Kim, DK; Nedumaran, B; Jang, WG; Cho, WJ; Ha, J; Lee, IK; Lee, CH; Choi, HS,期刊：Diabetes, 页码：306-314 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Metformin is an antidiabetic drug commonly used to treat type 2 diabetes. The aim of the study was to determine whether metformin regulates hepatic gluconeogenesis through the orphan nuclear receptor small hete... Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis [作者：van Harmelen, V; Eriksson, A; Astrom, G; Wahlen, K; Naslund, E; Karpe, F; Frayn, K; Oisson, T; Amdersson, J; Ryden, M; Arner, P,期刊：Diabetes, 页码：378-386 , 文章类型： Article，,卷期：2008年57-2] OBJECTAT-Visceral obesity increases risk of insulin resistance and type 2 diabetes. This may partly be due to a region-specific resistance to insulin's antilipolytic effect in visceral adipocytes. We investigated whether... Islet expression of M3 uncovers a key role for chemokines in the development and recruitment of diabetogenic cells in NOD mice [作者：Martin, AP; Grisotto, MG; Canasto-Chibuque, C; Kunkel, SL; Bromberg, JS; Furtado, GC; Lira, SA,期刊：Diabetes, 页码：387-394 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Type 1 diabetes is an autoimmune disease characterized by a local inflammatory reaction in and around islets followed by selective destruction of insulin-secreting beta-cells. We tested the hypothesis that chem... Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice - Imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics [作者：Lauritzen, HPMM; Galbo, H; Brandauer, J; Goodyear, LJ; Ploug, T,期刊：Diabetes, 页码：315-324 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Insulin stimulates glucose transport in skeletal muscle by GLUT4 translocation from intracellular compartments to sarcolemma and t-tubules. We studied in living animals the recruitment of GLUT4 vesicles in more... Marginal-zone B-Cells of Nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-Cells [作者：Marino, E; Batten, M; Groom, J; Walters, S; Liuwantara, D; Mackay, F; Grey, ST,期刊：Diabetes, 页码：395-404 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-B-cells are important for disease pathogenesis in the nonobese diabetic (NOD) mouse model of type 1 diabetes. Recent studies demonstrate that marginal-zone B-cells(MZBs), which connect innate with adaptive immu... Glucagon-like peptide-1 inhibits blood-brain glucose transfer in humans [作者：Lerche, S; Brock, B; Rungby, J; Botker, HE; Moller, N; Rodell, A; Bibby, BM; Holst, JJ; Schmitz, O; Gjedde, A,期刊：Diabetes, 页码：325-331 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Glucagon-like peptide-1 (GLP-1) has many effects on glucose homeostasis, mid GLP-1 receptors are broadly represented in many tissues including the brain. Recent research in rodents suggests a protective effect ... Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation [作者：Simon, G; Parker, M; Ramiya, V; Wasserfall, C; Huang, YF; Bresson, D; Schwartz, RF; Campbell-Thompson, M; Tenace, L; Brusko, T; Xue, S; Scaria, A; Lukason, M; Eisenbeis, S; Williams, J; Clare-Salzler, M; Schatz, D; Kaplan, B; von Herrath, M; Womer, K; Atkinson, MA,期刊：Diabetes, 页码：405-414 , 文章类型： Article，,卷期：2008年57-2] OBJECTIVE-Antilymphocyte serum can reverse overt type 1 diabetes in NOD mice; yet, the therapeutic parameters and immunological mechanisms underlying the ability for this agent to modulate autoimmune responses against be...