- Poglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
[作者：Ravikumar, B; Gerrard, J; Man, CD; Firbank, MJ; Lane, A; English, PT; Cobelli, C; Taylor, R,期刊：Diabetes, 页码：2288-2295 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Hepatic triglyceride is closely associated with hepatic insulin resistance and is known to be decreased by thiazolididinediones. We studied the effect of pioglitazone on hepatic triglyceride content and the con...
- Carcinoembryonic antigen-related cell adhesion molecule 1 - A link between insulin and lipid metabolism
[作者：DeAngelis, AM; Heinrich, G; Dai, T; Bowman, TA; Patel, PR; Lee, SJ; Hong, EG; Jung, DY; Assmann, A; Kulkarni, RN; Kim, JK; Najjar, SM,期刊：Diabetes, 页码：2296-2303 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant-negative transgene (L-SACC1 mice) impaired insulin clearance, caused insulin resistance, and incr...
- Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
[作者：van den Hoek, AM; van Heijningen, C; der Elst, JPSV; Ouwens, DM; Havekes, LM; Romijn, JA; Kalsbeek, A; Pijl, H,期刊：Diabetes, 页码：2304-2310 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-We recently showed that intracerebroventricular infusion of neuropeptide Y (NPY) hampers inhibition of endogenous glucose production (EGP) by insulin in mice. The downstream mechanisms responsible for these eff...
- Deletion of Cd39/Entpd1 results in hepatic insulin resistance
[作者：Enjyoji, K; Kotani, K; Thukral, C; Blumel, B; Sun, XF; Wu, Y; Imai, M; Friedman, D; Csizmadia, E; Bleibel, W; Kahn, BB; Robson, SC,期刊：Diabetes, 页码：2311-2320 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Extracellular nucleotides are important mediators of inflammatory responses and could also impact metabolic homeostasis. Type 2 purinergic (P2) receptors bind extracellular nucleotides and are expressed by majo...
- Pyruvate dehydrogenase kinase 4 - Regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue
[作者：Cadoudal, T; Distel, E; Durant, S; Fouque, F; Blouin, JM; Collinet, M; Bortoli, S; Forest, C; Benelli, C,期刊：Diabetes, 页码：2272-2279 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Pyruvate dehydrogenase complex (PDC) serves as the metabolic switch between glucose and fatty acid utilization. PDC activity is inhibited by PDC kinase (PDK). PDC shares the same substrate, i.e., pyruvate, as g...
- Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
[作者：Soro-Paavonen, A; Watson, AMD; Li, J; Paavonen, K; Koitka, A; Calkin, AC; Barit, D; Coughlan, MT; Drew, BG; Lancaster, GI; Thomas, M; Forbes, JM; Nawroth, PP; Bierhaus, A; Cooper, ME; Jandeleit-Dahm, KA,期刊：Diabetes, 页码：2461-2469 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Activation of the receptor for advanced glycation end products (RAGE) in diabetic vasculature is considered to be a key mediator of atherogenesis. This study examines the effects of deletion of RAGE on the deve...
- Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis
[作者：Caglayan, E; Stauber, B; Collins, AR; Lyon, CJ; Yin, F; Liu, J; Rosenkranz, S; Erdmann, E; Peterson, LE; Ross, RS; Tangirala, RK; Hsueh, WA,期刊：Diabetes, 页码：2470-2479 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Cardiac fibrosis is an important component of diabetic cardiomyopathy. Peroxisome proliferator-activated receptor gamma (PPAR gamma) ligands repress proinflammatory gene expression, including that of osteoponti...
- Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36
[作者：Rogers, PM; Mashtalir, N; Rathod, MA; Dubuisson, O; Wang, Z; Dasuri, K; Babin, S; Gupta, A; Markward, N; Cefalu, WT; Dhurandhar, NV,期刊：Diabetes, 页码：2321-2331 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Experimental infection of rat's with human adenovirus type 36 (Ad-36) promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the pharmacologic effect of thiozolinediones. To exploit t...
- Palmitate impairs and eieosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
[作者：Kato, T; Shimano, H; Yamamoto, T; Ishikawa, M; Kumadaki, S; Matsuzaka, T; Nakagawa, Y; Yahagi, N; Nakakuki, M; Hasty, AH; Takeuchi, Y; Kobayashi, K; Takahashi, A; Yatoh, S; Suzuki, H; Sone, H; Yamada, N,期刊：Diabetes, 页码：2382-2392 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for Lipogenesis.RESE...
- Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice
[作者：Fukuda, A; Kawaguchi, Y; Furuyama, K; Kodama, S; Horiguchi, M; Kuhara, T; Kawaguchi, M; Terao, M; Doi, R; Wright, CVE; Hoshino, M; Chiba, T; Uemoto, S,期刊：Diabetes, 页码：2421-2431 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells. In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent neonatal diabetes associated with panc...
- Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes
[作者：Makinen, VP; Forsblom, C; Thorn, LM; Waden, J; Gordin, D; Heikkila, O; Hietala, K; Kyllonen, L; Kyto, J; Rosengard-Barlund, M; Saraheimo, M; Tolonen, N; Parkkonen, M; Kaski, K; Ala-Korpela, M; Groop, PH,期刊：Diabetes, 页码：2480-2487 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIEVE-Poor glycemic control, elevated triglycerides, and albuminuria are associated with vascular complications in diabetes. However, few studies have investigated combined associations between metabolic markers, di...
- Cholinergic regulation of ghrelin and peptide YY release may be impaired in obesity
[作者：Maier, C; Riedl, M; Vila, G; Nowotny, P; Wolzt, M; Clodi, M; Ludvik, B; Luger, A,期刊：Diabetes, 页码：2332-2340 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Ghrelin and peptide YY (PYY) are both hormones derived from the gastrointestinal tract involved in appetite regulation. The cholinergic part of the vagal nerve is involved in the regulation of glucose and insul...
- Rapamycin monotherapy in patients with type 1 diabetes modifies CD4(+)CD25(+)FOXP3(+) regulatory T-Cells
[作者：Monti, P; Scirpoli, M; Maffi, P; Piemonti, L; Secchi, A; Bonifacio, E; Roncarolo, MG; Battaglia, M,期刊：Diabetes, 页码：2341-2347 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Rapamycin is an immunosuppressive drug currently used to prevent graft rejection in humans, which is considered permissive for tolerance induction. Rapamycin allows expansion of both murine and human naturally ...
- Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
[作者：Butty, V; Campbell, C; Mathis, D; Benoist, C,期刊：Diabetes, 页码：2348-2359 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-The unfolding of type 1 diabetes involves a number of steps: defective immunological tolerance, priming of anti-islet autoimmunity, and destruction of insulin-producing P-cells. A number of genetic loci contrib...
- Formation of composite endothelial cell-mesenchymal stem cell islets - A novel approach to promote islet revascularization
[作者：Johansson, U; Rasmusson, I; Niclou, SP; Forslund, N; Gustavsson, L; Nilsson, B; Korsgren, O; Magnusson, PU,期刊：Diabetes, 页码：2393-2401 , 文章类型： Article，,卷期：2008年57-9]
- OBJECTIVE-Mesenchymal stern cells (MSCs) contribute to endothelial cell (EC) migration by producing proteases, thereby paving the way into the tissues for ECs. MSCs were added to our previously described composite EC isl...
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