- Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease
[作者：Lan, H; Hoos, LM; Liu, L; Tetzloffl, G; Hu, WW; Abbondanzo, SJ; Vassileva, G; Gustafson, EL; Hedrick, JA; Davis, HR,期刊：Diabetes, 页码：2999-3006 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-FFAR1/GPR40 is a G-protein-coupled receptor expressed predominantly in pancreatic islets mediating free fatty acid-induced insulin secretion. However, the physiological role of FFAR1 remains controversial. It w...
- Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children Association With Progressive Insulin Resistance, Poor beta-Cell Function, and Increasing Visceral Fat
[作者：Goran, MI; Lane, C; Toledo-Corral, C; Weigensberg, MJ,期刊：Diabetes, 页码：3007-3012 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-To examine changes in risk factors in overweight and obese Hispanic children at high risk of developing type 2 diabetes.RESEARCH DESIGN AND METHODS-We recruited 128 overweight/obese Hispanic children with a fam...
- Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
[作者：Fiorina, P; Vergani, A; Dada, S; Jurewicz, M; Wong, M; Law, K; Wu, EX; Tian, Z; Abdi, R; Guleria, I; Rodig, S; Danussi-Joannopoulos, K; Bluestone, JR; Sayegh, MH,期刊：Diabetes, 页码：3013-3024 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVES-To investigate a B-cell-depleting strategy to reverse diabetes in naive NOD mice.RESEARCH DESIGN AND METHODS-We targeted the CD22 receptor on B-cells of naive NOD mice to deplete and reprogram B-cells to effec...
- Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
[作者：Martin, AP; Rankin, S; Pitchford, S; Charo, IF; Furtado, GC; Lira, SA,期刊：Diabetes, 页码：3025-3033 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-To define the mechanisms underlying the accumulation of monocytes/macrophages in the islets of Langerhans.RESEARCH DESIGN AND METHODS-We tested the hypothesis that macrophage accumulation into the islets is cau...
- Cytokine-Induced beta-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
[作者：Akerfeldt, MC; Howes, J; Chan, JY; Stevens, VA; Boubenna, N; McGuire, HM; King, C; Biden, TJ; Laybutt, DR,期刊：Diabetes, 页码：3034-3044 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-Cytokines contribute to beta-cell destruction in type 1 diabetes. Endoplasmic reticulum (ER) stress-mediated apoptosis has been proposed as a mechanism for beta-cell death. We tested whether ER stress was neces...
- beta-Cell Mass and Type 1 Diabetes Going, Going, Gone?
[作者：Akirav, E; Kushner, JA; Herold, KC,期刊：Diabetes, 页码：2883-2888 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE - beta-Cell regeneration is a fundamental but elusive goal for type 1 diabetes research. Our objective is to review newer human and animal studies of beta-cell destruction and regeneration and consider the impl...
- Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3
[作者：Bugger, H; Boudina, S; Hu, XX; Tuinei, J; Zaha, VG; Theobald, HA; Yun, UJ; McQueen, AP; Wayment, B; Litwin, SE; Abel, ED,期刊：Diabetes, 页码：2924-2932 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-Fatty acid-induced mitochondrial uncoupling and oxidative stress have been proposed to reduce cardiac efficiency and contribute to cardiac dysfunction in type 2 diabetes. We hypothesized that mitochondrial unco...
- Endurance Exercise as a Countermeasure for Aging
[作者：Lanza, IR; Short, DK; Short, KR; Raghavakaimal, S; Basu, R; Joyner, MJ; McConnell, JP; Nair, KS,期刊：Diabetes, 页码：2933-2942 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-We determined whether reduced insulin sensitivity, mitochondrial dysfunction, and other age-related dysfunctions are inevitable consequences of aging or secondary to physical inactivity.RESEARCH DESIGN AND METH...
- Lower Intrinsic ADP-Stimulated: Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
[作者：Phielix, E; Schranwen-Hinderling, VB; Mensink, M; Lenaers, E; Meex, R; Hoeks, J; Kooi, ME; Moonen-Kornips, E; Sels, JP; Hesselink, MKC; Schrauwen, P,期刊：Diabetes, 页码：2943-2949 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-A lower in vivo mitochondrial function has been reported in both type 2 diabetic patients and first-degree relatives of type 2 diabetic patients. The nature of this reduction is unknown. Here, we tested the hyp...
- Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
[作者：Marzban, L; Tomas, A; Becker, TC; Rosenberg, L; Oberholzer, J; Fraser, PE; Halban, PA; Verchere, CB,期刊：Diabetes, 页码：3045-3055 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-Islet amyloid, formed by aggregation of the beta-cell peptide islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of pancreatic islets in type 2 diabetes. Toxic LAPP aggregates likely con...
- Lymphocytes of Type 2 Diabetic Women Carry a High Load of Stable Chromosomal Aberrations A Novel Risk Factor for Disease-Related Early Death
[作者：Boehm, BO; Moller, P; Hogel, J; Winkelmann, BR; Renner, W; Rosinger, S; Seelhorst, U; Wellnitz, B; Maerz, W; Melzner, J; Bruderlein, S,期刊：Diabetes, 页码：2950-2957 , 文章类型： Article，,卷期：2008年57-11]
- OBJECTIVE-Diabetes is associated with an increased risk of death in women. Oxidative stress due to chronic hyperglycemia leads to the generation of reactive oxygen species and loss of chromosomal integrity. To clarify wh...
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