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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Chemical Logic and Enzymatic Machinery for Biological Assembly of Peptidyl Nucleoside Antibiotics [作者：WALSH CHRISTOPHER T; ZHANG WENJUN,期刊：ACS CHEMICAL BIOLOGY, 页码：1000-1007 , 文章类型： Article，,卷期：2011年6-10] Peptidyl nucleoside antibiotics are a group of natural products targeting MraY, a bacterial translocase involved in the lipid-linked cycle in peptidoglycan biosynthesis. In this Perspective, we explore how Nature builds ... Selective Targeting of Disease-Relevant Protein Binding Domains by O-Phosphorylated Natural Product Derivatives [作者：GRAEBER MARTIN; JANCZYK WERONIKA; SPERL BIANCA; ELUMALAI NAGARAJAN; KOZANY CHRISTIAN; HAUSCH FELIX; HOLAK TAD A; BERG THORSTEN,期刊：ACS CHEMICAL BIOLOGY, 页码：1008-1014 , 文章类型： Article，,卷期：2011年6-10] Phosphorylation-dependent protein binding domains are crucially important for intracellular signaling pathways and thus highly relevant targets in chemical biology. By screening of chemical libraries against 12 structura... Chemoenzymatic Labeling of Protein C-Termini for Positive Selection of C-Terminal Peptides [作者：XU GUOQIANG; SHIN SUNG BIN Y; JAFFREY SAMIE R,期刊：ACS CHEMICAL BIOLOGY, 页码：1015-1020 , 文章类型： Article，,卷期：2011年6-10] Many proteomic experiments require selective labeling of either N- or C-termini of proteins and recovery of terminal peptides. Although N-termini can be selectively labeled, selective labeling of protein C-termini has no... Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson's Disease-Related Toxicity in Human Neurons [作者：RAMSDEN NIGEL; PERRIN JESSICA; REN ZHAO; LEE BYOUNG DAE; ZINN NICO; DAWSON VALINA L; TAM DANNY; BOVA MICHAEL; LANG MANJA; DREWES GERARD; BANTSCHEFF MARCUS; BARD FREDERIQUE; DAWSON TED M; HOPF CARSTEN,期刊：ACS CHEMICAL BIOLOGY, 页码：1021-1028 , 文章类型： Article，,卷期：2011年6-10] Leucine-rich repeat kinase-2 (LRRK2) mutations are the most important cause of familial Parkinson's disease, and non-selective inhibitors are protective in rodent disease models. Because of their poor potency and selecti... Selective Reduction of Methylsulfinyl-Containing Compounds by Mammalian MsrA Suggests a Strategy for Improved Drug Efficacy [作者：LEE BYUNG CHEON; FOMENKO DMITRI E; GLADYSHEV VADIM N,期刊：ACS CHEMICAL BIOLOGY, 页码：1029-1035 , 文章类型： Article，,卷期：2011年6-10] Identification of pathways of drug metabolism provides critical information regarding, efficacy and safety of these compounds. Particularly challenging cases involve stereospecific processes. We found that broad classes ... Discovery of a Cytokinin Deaminase [作者：GOBLE ALISSA M; FAN HAO; SALI ANDREJ; RAUSHEL FRANK M,期刊：ACS CHEMICAL BIOLOGY, 页码：1036-1040 , 文章类型： Article，,卷期：2011年6-10] An enzyme of unknown function within the amidohydrolase superfamily was discovered to catalyze the hydrolysis Of N-6-substituted adenine derivatives, several of which are cytokinins. Cytokinins are a common type of plant... Receptor-Mediated Cellular Uptake Mechanism That Couples to Intracellular Storage [作者：KAWAGUCHI RIKI; YU JIAMEI; TERSTEPANIAN MARIAM; ZHONG MING; CHENG GUO; YUAN QUAN; JIN MINGHAO; TRAVIS GABRIEL H; ONG DAVID; SUN HUI,期刊：ACS CHEMICAL BIOLOGY, 页码：1041-1051 , 文章类型： Article，,卷期：2011年6-10] Cells are known to take up molecules through membrane transport mechanisms such as active transport, channels, and facilitated transport. We report here a new membrane transport mechanism that employs neither cellular en... Protein-Induced Long Lifetime Luminescence of Nonmetal Probes [作者：ENKVIST ERKI; VAASA ANGELA; KASARI MARJE; KRIISA MARIE; IVAN TAAVI; LIGI KADRI; RAIDARU GERDA; URI ASKO,期刊：ACS CHEMICAL BIOLOGY, 页码：1052-1062 , 文章类型： Article，,卷期：2011年6-10] Time-resolved luminometry-based assays have great potential for measurements in complicated biological solutions and living cells as,the measured signal can be easily distinguished from nanosecond lifetime back ground fl... Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor [作者：VAN ARNAM ETHAN B; LESTER HENRY A; DOUGHERTY DENNIS A,期刊：ACS CHEMICAL BIOLOGY, 页码：1063-1068 , 文章类型： Article，,卷期：2011年6-10] G protein-coupled receptors (GPCRs) contain a number of conserved proline residues in their transmembrane helices, and it is generally assumed these play important functional and/or structural roles. Here we use unnatura... Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry [作者：ACHARYA PRIYAMVADA; DOGOISONAGIE CAJETAN; LALONDE JUDITH M; LAM SON N; LESLIE GEORGE J; LOUDER MARK K; FRYE LEAH L; DEBNATH ASIM K; GREENWOOD JEREMY R; LUONGO TIMOTHY S; MARTIN LOIC; WATTS K SHAWN; HOXIE JAMES A; MASCOLA JOHN R; BEWLEY CAROLE A; KWONG PETER D,期刊：ACS CHEMICAL BIOLOGY, 页码：1069-1077 , 文章类型： Article，,卷期：2011年6-10] Tyrosine sulfate-mediated interactions play an important role in HIV-1 entry. After engaging the CD4 receptor at the cell surface, the HIV-1 gp120 glycoprotein binds to the CCR5 co-receptor via an interaction that requir... Using Self-Assembled Monolayers To Understand alpha 8 beta 1-Mediated Cell Adhesion to RGD and FEI Motifs in Nephronectin [作者：SANCHEZCORTES JUAN; MRKSICH MILAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1078-1086 , 文章类型： Article，,卷期：2011年6-10] Nephronectin is an extracellular matrix protein that interacts with the alpha 8 beta 1 integrin receptor and plays a role in tissue and organ development, though the motifs that mediate adhesion to the receptor remain un... Proteasomal Degradation from Internal Sites Favors Partial Proteolysis via Remote Domain Stabilization [作者：KRAUT DANIEL A; MATOUSCHEK ANDREAS,期刊：ACS CHEMICAL BIOLOGY, 页码：1087-1095 , 文章类型： Article，,卷期：2011年6-10] The ubiquitin-proteasome system controls the concentrations of hundreds of regulatory proteins and removes misfolded and damaged proteins in eukaryotic cells. The proteasome recognizes ubiquitinated proteins and then eng... Similarities and Differences between Two Modes of Antagonism of the Thyroid Hormone Receptor [作者：SADANA PRABODH; HWANG JONG YEON; ATTIA RAMY R; ARNOLD LEGGY A; NEALE GEOFFREY; GUY R KIPLIN,期刊：ACS CHEMICAL BIOLOGY, 页码：1096-1106 , 文章类型： Article，,卷期：2011年6-10] Thyroid hormone (T3) mediates diverse physiological functions including growth, differentiation, and energy homeostasis through the thyroid hormone receptors (TR). The TR binds DNA at specific recognition sequences in th... proTeOn and proTeOff, New Protein Devices That Inducibly Activate Bacterial Gene Expression [作者：VOLZING KATHERINE; BILIOURIS KONSTANTINOS; KAZNESSIS YIANNIS N,期刊：ACS CHEMICAL BIOLOGY, 页码：1107-1116 , 文章类型： Article，,卷期：2011年6-10] Using an original workflow, we have modeled, constructed, and characterized two new molecular devices that inducibly activate gene expression in Escherichia coli. The devices, prokaryotic-TetOn and prokaryotic-TetOff, we... Immobilizing Reporters for Molecular Imaging of the Extracellular Microenvironment in Living Animals [作者：XIA ZUYONG; XING YUN; JEON JONGHO; KIM YOUNGPIL; GALL JESSICA; DRAGULESCUANDRASI ANCA; GAMBHIR SANJIV S; RAO JIANGHONG,期刊：ACS CHEMICAL BIOLOGY, 页码：1117-1126 , 文章类型： Article，,卷期：2011年6-10] We report here an immobilization strategy using a collagen,binding protein to deliver and confine synthetic reporters to the extracellular microenvironment in vivo for noninvasively imaging the activity of targets in the... Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1 [作者：OBIANYO OBIAMAKA; CAUSEY COREY P; JONES JUSTIN E; THOMPSON PAUL R,期刊：ACS CHEMICAL BIOLOGY, 页码：1127-1135 , 文章类型： Article，,卷期：2011年6-10] The protein arginine methyltransferases (PRMTs) are SAM-dependent enzymes that catalyze the mono- and dimethylation of peptidyl arginine residues. PRMT1 is the founding member of the PRMT family, and this isozyme is resp...