个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism [作者：SILVIAN LAURA F; FRIEDMAN JESSICA E; STRAUCH KATHY; CACHERO TERESA G; DAY ERIC S; QIAN FANG; CUNNINGHAM BRIAN; FUNG AMY; SUN LIHONG; SU LIHE; ZHENG ZHONGLI; KUMARAVEL GNANASAMBANDAM; WHITTY ADRIAN,期刊：ACS CHEMICAL BIOLOGY, 页码：636-647 , 文章类型： Article，,卷期：2011年6-6] BIO8898 is one of several synthetic organic molecules that have recently been reported to inhibit receptor binding, and function of the constitutively trimeric tumor necrosis factor (TNF) family cytokine CD40 ligand (CD4... Probing Elongating and Branching beta-D-Galactosyltransferase Activities in Leishmania Parasites by Making Use of Synthetic Phosphoglycans [作者：SIZOVA OLGA V; ROSS ANDREW J; IVANOVA IRINA A; BORODKIN VLADIMIR S; FERGUSON MICHAEL A J; NIKOLAEV ANDREI V,期刊：ACS CHEMICAL BIOLOGY, 页码：648-657 , 文章类型： Article，,卷期：2011年6-6] Protozoan parasites of the genus Leishmania synthesize lipophosphoglycans (LPGs), phosphoglycans and proteophosphoglycans that contain phosphosaccharide repeat units of [(-6)Gal(beta 1-4)Man alpha 1-OPO3H-]. The repeat s... Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell Migration [作者：KAOUD TAMER S; MITRA SHREYA; LEE SUNBAE; TALIAFERRO JULIANA; CANTRELL MICHAEL; LINSE KLAUS D; VAN DEN BERG CARLA L; DALBY KEVIN N,期刊：ACS CHEMICAL BIOLOGY, 页码：658-666 , 文章类型： Article，,卷期：2011年6-6] Despite their lack of selectivity toward c-Jun N-terminal kinase (JNK) isoforms, peptides derived from the JIP (JNK Interacting Protein) scaffolds linked to the cell-penetrating peptide TAT are widely used to investigate... Innovative Research at the Interface of Chemistry and Biology [作者：SOARES JITESH,期刊：ACS CHEMICAL BIOLOGY, 页码：521-522 , 文章类型： Editorial Material，,卷期：2011年6-6] Light-Driven Cytochrome P450 Hydroxylations [作者：JENSEN KENNETH; JENSEN POUL ERIK; MOLLER BIRGER LINDBERG,期刊：ACS CHEMICAL BIOLOGY, 页码：533-539 , 文章类型： Article，,卷期：2011年6-6] Plants are light-driven "green" factories able to synthesize more; than 200,000 different bioactive natural products, many of which are high-value products used as drugs (e.g., artemisinin, taxol, and thapsigargin). In t... A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase [作者：TAYLOR DAVID M; BALABADRA UMA; XIANG ZHONGMIN; WOODMAN BEN; MEADE SARAH; AMORE ALLISON; MAXWELL MICHELE M; REEVES STEVEN; BATES GILLIAN P; LUTHICARTER RUTH; LOWDEN PHILIP A S; KAZANTSEV ALEKSEY G,期刊：ACS CHEMICAL BIOLOGY, 页码：540-546 , 文章类型： Article，,卷期：2011年6-6] Sirtuin 2 (SIRT2) deacetylase-dependent inhibition mediates neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington's disease model. This study sought to identify the first brain permeable SIRT2 i... Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish [作者：DEHNERT KAREN W; BEAHM BRENDAN J; HUYNH THINH T; BASKIN JEREMY M; LAUGHLIN SCOTT T; WANG WEI; WU PENG; AMACHER SHARON L; BERTOZZI CAROLYN R,期刊：ACS CHEMICAL BIOLOGY, 页码：547-552 , 文章类型： Article，,卷期：2011年6-6] Many developmental processes depend on proper fucosylation, but this post-translational modification is difficult to monitor in vivo. Here we applied a chemical reporter strategy to visualize fucosylated glycans in devel... Novel Chemically Defined Approach To Produce Multipotent Cells from Terminally Differentiated Tissue Syncytia [作者：JUNG DAWOON; WILLIAMS DARREN R,期刊：ACS CHEMICAL BIOLOGY, 页码：553-562 , 文章类型： Article，,卷期：2011年6-6] In urodele amphibians, a critical step in limb regeneration is the cellularization and dedifferentiation of skeletal muscle. In contrast, mammalian skeletal muscle does not undergo this response to injury. We have develo... Development of Activity-Based Probes for Cathepsin X [作者：PAULICK MARGOT G; BOGYO MATTHEW,期刊：ACS CHEMICAL BIOLOGY, 页码：563-572 , 文章类型： Article，,卷期：2011年6-6] Cathepsin X is a lysosomal cysteine protease that functions as a carboxypeptidase with broad substrate specificity. Cathepsin X was discovered only recently, and its physiological roles are still not well understood. A n... Identification of a Polyoxometalate Inhibitor of the DNA Binding Activity of Sox2 [作者：NARASIMHAN KAMESH; PILLAY SHUBHADRA; BIN AHMAD NOR RIZAL; ZSOLT BIKADI; ESZTER HAZAI; YAN LI; KOLATKAR PRASANNA R; PERVUSHIN KONSTANTIN; JAUCH RALF,期刊：ACS CHEMICAL BIOLOGY, 页码：573-581 , 文章类型： Article，,卷期：2011年6-6] Aberrant expression of transcription factors is a frequent cause of disease, yet drugs that modulate transcription factor protein-DNA interactions are presently unavailable. To this end, the chemical tractability of the ... Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing [作者：FAN LIYING; LAGISETTI CHANDRAIAH; EDWARDS CAROL C; WEBB THOMAS R; POTTER PHILIP M,期刊：ACS CHEMICAL BIOLOGY, 页码：582-589 , 文章类型： Article，,卷期：2011年6-6] Two unrelated bacterial natural products, FR901464 and pladienolide B, have previously been shown to have significant antitumor activity in vivo. These compounds target the SF3b subunit of the spliceosome, with a derivat... Antibacterial Studies of Cationic Polymers with Alternating, Random, and Uniform Backbones [作者：SONG AIRONG; WALKER STEPHEN G; PARKER KATHLYN A; SAMPSON NICOLE S,期刊：ACS CHEMICAL BIOLOGY, 页码：590-599 , 文章类型： Article，,卷期：2011年6-6] Antibacterial polymers have potential as pharmaceuticals and as coatings for implantation devices. The design of these materials will be optimized when we have a complete understanding of the structural features that imp... Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer [作者：KOIDE YUICHIRO; URANO YASUTERU; HANAOKA KENJIRO; TERAI TAKUYA; NAGANO TETSUO,期刊：ACS CHEMICAL BIOLOGY, 页码：600-608 , 文章类型： Article，,卷期：2011年6-6] The absorption and emission wavelengths. of group 14 pyronines and rhodamines, which contain silicon, germanium, or tin at the 10 position of the xanthene chromophore, showed large bathochromic shifts compared to the ori... Mapping the Pro-Peptide of the Schistosoma mansoni Cathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors [作者：HORN MARTIN; JILKOVA ADELA; VONDRASEK JIRI; MARESOVA LUCIE; CAFFREY CONOR R; MARES MICHAEL,期刊：ACS CHEMICAL BIOLOGY, 页码：609-617 , 文章类型： Article，,卷期：2011年6-6] Blood flukes of the genus Schistosoma cause the disease schistosomiasis that infects over 200 million people worldwide. Treatment relies on just one drug, and new therapies are needed should drug resistance emerge. Schis... Identification of a Novel Non-retinoid Pan Inverse Agonist of the Retinoic Acid Receptors [作者：BUSBY SCOTT A; KUMAR NARESH; KURUVILLA DANA S; ISTRATE MONICA A; CONKRIGHT JULIANA J; WANG YONGJUN; KAMENECKA THEODORE M; CAMERON MICHAEL D; ROUSH WILLIAM R; BURRIS THOMAS P; GRIFFIN PATRICK R,期刊：ACS CHEMICAL BIOLOGY, 页码：618-627 , 文章类型： Article，,卷期：2011年6-6] Retinoids are potent forms of vitamin A and are involved in a broad, range of physiological processes and the pharmacological effects of retinoids are primarily mediated by the retinoic acid receptors (RARs) and the reti... Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening [作者：HUANG FEI; MOTLEKAR NUZHAT A; BURGWIN CHELSEA M; NAPPER ANDREW D; DIAMOND SCOTT L; MAZIN ALEXANDER V,期刊：ACS CHEMICAL BIOLOGY, 页码：628-635 , 文章类型： Article，,卷期：2011年6-6] RAD51 is a key protein of homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL). To better understand the cellular function(s) of human RAD5...