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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor [作者：ZHANG MENGMENG; CHO EUN JEONG; BURSTEIN GAYLE; SIEGEL DIONICIO; ZHANG YAN,期刊：ACS CHEMICAL BIOLOGY, 页码：511-519 , 文章类型： Article，,卷期：2011年6-5] The unstructured C-terminal domain (CTD) of eukaryotic RNA polymerase II dynamically regulates the process of transcription by recruiting different factors to nascent mRNA through its multiple phosphorylation patterns. A... Honoring Stuart Schreiber [作者：SOARES JITESH,期刊：ACS CHEMICAL BIOLOGY, 页码：385-386 , 文章类型： Editorial Material，,卷期：2011年6-5] Biophysics at the Cutting Edge: A Report from the 55th Annual Meeting of the Biophysical Society [作者：PAL PRITHWISH,期刊：ACS CHEMICAL BIOLOGY, 页码：395-400 , 文章类型： Editorial Material，,卷期：2011年6-5] Chromophore-Assisted Light Inactivation of HaloTag Fusion Proteins Labeled with Eosin in Living Cells [作者：TAKEMOTO KIWAMU; MATSUDA TOMOKI; MCDOUGALL MARK; KLAUBERT DIETER H; HASEGAWA AKIRA; LOS GEORGYI V; WOOD KEITH V; MIYAWAKI ATSUSHI; NAGAI TAKEHARU,期刊：ACS CHEMICAL BIOLOGY, 页码：401-406 , 文章类型： Article，,卷期：2011年6-5] Chromophore-assisted light inactivation (CALI) is a potentially powerful tool for the acute disruption of a target protein inside living cells with high spatiotemporal resolution. This technology, however, has not been w... ABC Transporters Required for Export of Wall Teichoic Acids Do Not Discriminate between Different Main Chain Polymers [作者：SCHIRNER KATHRIN; STONE LAURA K; WALKER SUZANNE,期刊：ACS CHEMICAL BIOLOGY, 页码：407-412 , 文章类型： Article，,卷期：2011年6-5] The cell envelopes of Gram-positive bacteria comprise two major constituents, peptidoglycan and teichoic acids. Wall teichoic acids (WTAs) are anionic glycophosphate polymers that play important roles in bacterial cell g... Binding and pK(a) Modulation of a Polycyclic Substrate Analogue in a Type II Polyketide Acyl Carrier Protein [作者：HAUSHALTER ROBERT W; FILIPP FABIAN V; KO KWANGSEUK; YU RICKY; OPELLA STANLEY J; BURKART MICHAEL D,期刊：ACS CHEMICAL BIOLOGY, 页码：413-418 , 文章类型： Article，,卷期：2011年6-5] Type II polyketide synthases are biosynthetic enzymatic pathways responsible for the production of complex aromatic natural products with important biological activities. In these systems, biosynthetic intermediates are ... NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time [作者：DOSE ALEXANDER; LIOKATIS STAMATIOS; THEILLET FRANCOISXAVIER; SELENKO PHILIPP; SCHWARZER DIRK,期刊：ACS CHEMICAL BIOLOGY, 页码：419-424 , 文章类型： Article，,卷期：2011年6-5] Histone deacetylases (HDACs) and histone acetyl-transferases (HATs) are universal regulators of eukaryotic transcriptional activity and emerging therapeutic targets for human diseases. Here we describe the generation of ... Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers [作者：SUMIYA ERIKO; SHIMOGAWA HIROKI; SASAKI HIROAKI; TSUTSUMI MASATO; YOSHITA KENICHI; OJIKA MAKOTO; SUENAGA KIYOTAKE; UESUGI MOTONARI,期刊：ACS CHEMICAL BIOLOGY, 页码：425-431 , 文章类型： Article，,卷期：2011年6-5] Natural products provide a rich source of biological tools, but elucidating their molecular targets remains challenging. Here we report a cell morphological profiling of a natural product library, which permitted the ide... Alkylation of Cysteine 468 in Stat3 Defines a Novel Site for Therapeutic Development [作者：BUETTNER RALF; CORZANO RENZO; RASHID RUMANA; LIN JIANPING; SENTHIL MAHESWARI; HEDVAT MICHAEL; SCHROEDER ANNE; MAO ALLEN; HERRMANN ANDREAS; YIM JOHN; LI HONGZHI; YUAN YATECHING; YAKUSHIJIN KENICHI; YAKUSHIJIN FUMIKO; VAIDEHI NAGARAJAN; MOORE ROGER; GUGIU GABRIEL; LEE TERRY D; YIP RICHARD; CHEN YUAN; JOVE RICHARD; HORNE DAVID; WILLIAMS JOHN C,期刊：ACS CHEMICAL BIOLOGY, 页码：432-443 , 文章类型： Article，,卷期：2011年6-5] Stat3 is a latent transcription factor that promotes cell survival and proliferation and is often constitutively active in multiple cancers. Inhibition of Stat3 signaling pathways suppresses cell survival signals and lea... Genetic Targeting of a Voltage-Sensitive Dye by Enzymatic Activation of Phosphonooxymethyl-ammonium Derivative [作者：NG DAVID N; FROMHERZ PETER,期刊：ACS CHEMICAL BIOLOGY, 页码：444-451 , 文章类型： Article，,卷期：2011年6-5] Optical recording of action potentials in individual neurons requires cell-selective targeting with a fluorescent, voltage-sensitive probe. We report on a new labeling system that takes advantage of recent developments i... Identification and Optimization of Small Molecules That Restore E-Cadherin Expression and Reduce Invasion in Colorectal Carcinoma Cells [作者：STOOPS SYDNEY L; PEARSON A SCOTT; WEAVER CONNIE; WATERSON ALEX G; DAYS EMILY; FARMER CHRIS; BRADY SUZANNE; WEAVER C DAVID; BEAUCHAMP R DANIEL; LINDSLEY CRAIG W,期刊：ACS CHEMICAL BIOLOGY, 页码：452-465 , 文章类型： Article，,卷期：2011年6-5] E-cadherin is a transmembrane protein that maintains intercellular contacts and cell polarity in epithelial tissue. The down-regulation of E-cadherin contributes to the induction of the epithelial-to-mesenchymal transiti... Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4 [作者：SLACK JESSICA L; CAUSEY COREY P; LUO YUAN; THOMPSON PAUL R,期刊：ACS CHEMICAL BIOLOGY, 页码：466-476 , 文章类型： Article，,卷期：2011年6-5] The protein arginine deiminases (PADs), which catalyze the hydrolysis of peptidyl-arginine to form peptidyl-citrulline, are potential targets for the development of a rheumatoid arthritis (RA) therapeutic, as well as oth... Decoupling of the Catalytic and Transport Activities of Complex I from Rhodothermus marinus by Sodium/Proton Antiporter Inhibitor [作者：BATISTA ANA P; MARREIROS BRUNO C; PEREIRA MANUELA M,期刊：ACS CHEMICAL BIOLOGY, 页码：477-483 , 文章类型： Article，,卷期：2011年6-5] The energy transduction by complex I from Rhodothermus marinus was addressed by studying the influence of 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on the activities of this enzyme. EIPA is an inhibitor of both Na+/H+ ant... An Unusual Cell Penetrating Peptide Identified Using a Plasmid Display-Based Functional Selection Platform [作者：GAO SHAN; SIMON MELISSA J; HUE CHRISTOPHER D; MORRISON BARCLAY III; BANTA SCOTT,期刊：ACS CHEMICAL BIOLOGY, 页码：484-491 , 文章类型： Article，,卷期：2011年6-5] Cell penetrating peptides (CPPs) have tremendous potential for use in gene and drug delivery applications. The selection of new CPPs with desired capabilities from randomized peptide libraries is challenging, since the C... Discovery of a Potential Allosteric Ligand Binding Site in CDK2 [作者：BETZI STEPHANE; ALAM RIAZUL; MARTIN MATHEW; LUBBERS DONNA J; HAN HUIJONG; JAKKARAJ SUDHAKAR R; GEORG GUNDA I; SCHOENBRUNN ERNST,期刊：ACS CHEMICAL BIOLOGY, 页码：492-501 , 文章类型： Article，,卷期：2011年6-5] Cyclin-dependent kinases (CDKs) are key regulatory enzymes in cell cycle progression and transcription. Aberrant activity of CDKs has been implicated in a number of medical conditions, and numerous small molecule CDK inh... Identification, in Vitro Activity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules [作者：BAXTER BONNIE K; DIDONE LOUIS; OGU DUANA; SCHOR STANFORD; KRYSAN DAMIAN J,期刊：ACS CHEMICAL BIOLOGY, 页码：502-510 , 文章类型： Article，,卷期：2011年6-5] Although protein kinases have recently emerged as important drug targets, the anti-infective potential of protein kinase inhibitors has. not been developed extensively. We identified the mammalian PDK1 inhibitor KP-372-1...