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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   A p38 alpha-Selective Chemosensor for use in Unfractionated Cell Lysates [作者：STAINS CLIFF I; LUKOVIC ELVEDIN; IMPERIALI BARBARA,期刊：ACS CHEMICAL BIOLOGY, 页码：101-105 , 文章类型： Letter，,卷期：2011年6-1] Recent efforts have identified the p38 alpha Ser/Thr kinase as a potential target for the treatment of inflammatory diseases as well as non-small cell lung carcinoma. Despite the significance of p38 alpha no direct activ... Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses in Staphylococcus aureus [作者：CAMPBELL JENNIFER; SINGH ATUL K; MARIA JOHN P SANTA JR; KIM YOUNGHOON; BROWN STEPHANIE; SWOBODA JONATHAN G; MYLONAKIS ELEFTHERIOS; WILKINSON BRIAN J; WALKER SUZANNE,期刊：ACS CHEMICAL BIOLOGY, 页码：106-116 , 文章类型： Article，,卷期：2011年6-1] Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase (TP) with reduced susceptibility to beta-la... Fermenting Next Generation Glycosylated Therapeutics [作者：CHEN XI,期刊：ACS CHEMICAL BIOLOGY, 页码：14-17 , 文章类型： Article，,卷期：2011年6-1] Mutants of glycosyltransferases and:related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These dive... Reflections on Chemical Biology [作者：JOHNSSON KAI,期刊：ACS CHEMICAL BIOLOGY, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年6-1] Defining MAPK Interactomes [作者：JOHNSON GARY L,期刊：ACS CHEMICAL BIOLOGY, 页码：18-20 , 文章类型： Article，,卷期：2011年6-1] The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has... Retroviral Display in Gene Therapy, Protein Engineering, and Vaccine Development [作者：URBAN JOHANNES H; MERTEN CHRISTOPH A,期刊：ACS CHEMICAL BIOLOGY, 页码：61-74 , 文章类型： Article，,卷期：2011年6-1] The display and analysis of proteins expressed on biological surfaces has become an attractive tool for the study of molecular interactions In enzymology, protein engineering, and high-throughput screening. Among the gro... Transcript Profiling and RNA Interference as Tools To Identify Small Molecule Mechanisms and Therapeutic Potential [作者：PALCHAUDHURI RAHUL; HERGENROTHER PAUL J,期刊：ACS CHEMICAL BIOLOGY, 页码：21-33 , 文章类型： Article，,卷期：2011年6-1] The identification of the mechanism of action and therapeutic potential of bioactive small molecules remains a considerable challenge in the field of drug discovery and chemical biology. Apart from traditional target ide... Identification of Direct Protein Targets of Small Molecules [作者：LOMENICK BRETT; OLSEN RICHARD W; HUANG JING,期刊：ACS CHEMICAL BIOLOGY, 页码：34-46 , 文章类型： Article，,卷期：2011年6-1] Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To ove... Vigilance and Validation: Keys to Success in RNAi Screening [作者：SIGOILLOT FREDERIC D; KING RANDALL W,期刊：ACS CHEMICAL BIOLOGY, 页码：47-60 , 文章类型： Article，,卷期：2011年6-1] In the 12 years since the process of RNA interference (RNAi) was first discovered, great progress has been made in understanding its mechanism and exploiting its ability to silence gene expression to study gene function ... Using Small Molecules and Chemical Genetics To Interrogate Signaling Networks [作者：CARLSON SCOTT M; WHITE FOREST M,期刊：ACS CHEMICAL BIOLOGY, 页码：75-85 , 文章类型： Article，,卷期：2011年6-1] The limited clinical success of therapeutics targeting cellular signaling processes is due to multiple factors, including off-target effects and complex feedback regulation encoded within the signaling network. To unders... Small Molecule Probes of Cellular Pathways and Networks [作者：CASTORENO ADAM B; EGGERT ULRIKE S,期刊：ACS CHEMICAL BIOLOGY, 页码：86-94 , 文章类型： Article，,卷期：2011年6-1] Small molecules are important not only as therapeutics to treat disease but also as chemical tools to probe complex biological processes. The discovery of novel bioactive small molecules has largely been catalyzed by scr... Recombinant E. coil Prototype Strains for in Vivo Glycorandomization [作者：WILLIAMS GAVIN J; YANG JIE; ZHANG CHANGSHENG; THORSON JON S,期刊：ACS CHEMICAL BIOLOGY, 页码：95-100 , 文章类型： Letter，,卷期：2011年6-1] In vitro glycorandomization is a powerful strategy to alter the glycosylation patterns of natural products and small molecule therapeutics. Yet, such in vitro methods are often difficult to scale and can be costly given ...