- Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells
[作者:Luo, Y; Ling, Y; Guo, WS; Pang, J; Liu, WP; Fang, YQ; Wen, XQ; Wei, K; Gao, X,期刊:Journal of controlled release, 页码:278-288 , 文章类型: Article,,卷期:2010年147-2]
- Docetaxel (Dtxl) remains the preferred choice of improving the survival of patients with hormone refractory prostate cancer (HRPC), but many patients suffer from modest drug response and significant toxicity. In the pres...
- In vitro and in vivo characterisation of a novel peptide delivery system: Amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes
[作者:Cheng, WP; Thompson, C; Ryan, SM; Aguirre, T; Tetley, L; Brayden, DJ,期刊:Journal of controlled release, 页码:289-297 , 文章类型: Article,,卷期:2010年147-2]
- The cationic peptide, salmon calcitonin (sCT) was complexed with the cationic amphiphilic polyelectrolyte, poly(allyl)amine, grafted with palmitoyl and quaternary ammonium moieties at pH 5.0 and 7.4 to yield particulates...
- Hydrogels of collagen-inspired telechelic triblock copolymers for the sustained release of proteins
[作者:Teles, H; Vermonden, T; Eggink, G; Hennink, WE; de Wolf, FA,期刊:Journal of controlled release, 页码:298-303 , 文章类型: Article,,卷期:2010年147-2]
- We studied the release of entrapped protein from transient gels made of thermosensitive, collagen-inspired ABA triblock copolymers with tailorable properties and with mid blocks of two different lengths (similar to 37 kD...
- Nanoparticles by spray drying using innovative new technology: The Buchi Nano Spray Dryer B-90
[作者:Li, XA; Anton, N; Arpagaus, C; Belleteix, F; Vandanune, TF,期刊:Journal of controlled release, 页码:304-310 , 文章类型: Article,,卷期:2010年147-2]
- Spray drying technology is widely known and used to transform liquids (solutions, emulsions, suspension, slurries, pastes or even melts) into solid powders. Its main applications are found in the food, chemical and mater...
- Mesenchymal stem cells: A promising targeted-delivery vehicle in cancer gene therapy
[作者:Hu, YL; Fu, YH; Tabata, Y; Gao, JQ,期刊:Journal of controlled release, 页码:154-162 , 文章类型: Review,,卷期:2010年147-2]
- The targeting drug delivery systems (TDDS) have attracted extensive attention of researchers in recent years. More and more drug/gene targeted delivery carriers, such as liposome, magnetic nanoparticles, ligand-conjugate...
- Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: An original drug delivery pathway
[作者:Bildstein, L; Dubernet, C; Marsaud, V; Chacun, H; Nicolas, V; Gueutin, C; Sarasin, A; Benech, H; Lepetre-Mouelhi, S; Desmaele, D; Couvreur, P,期刊:Journal of controlled release, 页码:163-170 , 文章类型: Article,,卷期:2010年147-2]
- We have designed an amphiphilic prodrug of gemcitabine (dFdC) by its covalent coupling to a derivative of squalene, a natural lipid. The resulting bioconjugate self-assembled spontaneously in water as nanoparticles that ...
- Multimodal release of transforming growth factor-beta 1 and the BB isoform of platelet derived growth factor from PEGylated fibrin gels
[作者:Drinnan, CT; Zhang, G; Alexander, MA; Pulido, AS; Suggs, LJ,期刊:Journal of controlled release, 页码:180-186 , 文章类型: Article,,卷期:2010年147-2]
- We designed a growth factor release system to potentially stabilize neovascularization in the treatment of ischemic tissue. In this study, the release of PDGF-BB and TGF-beta 1 was controlled with distinct kinetics from ...
- Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system
[作者:Choi, DH; Park, CH; Kim, IH; Chun, HJ; Park, K; Han, DK,期刊:Journal of controlled release, 页码:193-201 , 文章类型: Article,,卷期:2010年147-2]
- To effectively harness the great potential of stem cells, we designed a dual growth factor delivery system for the application toward stem cell differentiation into specific lineages. This system carries a core shell str...
- The mechanism of protein release from triglyceride microspheres
[作者:Zaky, A; Elbakry, A; Ehmer, A; Breunig, M; Goepferich, A,期刊:Journal of controlled release, 页码:202-210 , 文章类型: Article,,卷期:2010年147-2]
- The purpose of this study was to reveal factors that have an impact on the protein release kinetics from triglyceride microspheres prepared by spray congealing. We investigated the effect of protein particle size, morpho...
- Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo
[作者:Bal, SM; Kruithof, AC; Zwier, R; Dietz, E; Bouwstra, JA; Lademann, J; Meinke, MC,期刊:Journal of controlled release, 页码:218-224 , 文章类型: Article,,卷期:2010年147-2]
- Microneedles can enhance the penetration of vaccines into the skin for transcutaneous vaccination. In this study for the first time the influence of microneedle geometry on the transport through the formed conduits was v...
- Trans-scleral iontophoretic delivery of low molecular weight therapeutics
[作者:Gungor, S; Delgado-Charro, MB; Ruiz-Perez, B; Schubert, W; Isom, P; Moslemy, P; Patane, MA; Guy, RH,期刊:Journal of controlled release, 页码:225-231 , 文章类型: Article,,卷期:2010年147-2]
- The fundamental understanding of ocular drug delivery using iontophoresis is not at the same level as that for transdermal electrotransport. Research has therefore been undertaken to characterise the electrical propertie...
- A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging
[作者:Kaunisto, E; Abrahmsen-Alami, S; Borgquist, P; Larsson, A; Nilsson, B; Axelsson, A,期刊:Journal of controlled release, 页码:232-241 , 文章类型: Article,,卷期:2010年147-2]
- In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water...
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