- IGF-I Bioactivity in an Elderly Population Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome
[作者：Brugts, MP; van Duijn, CM; Hofland, LJ; Witteman, JC; Lamberts, SWJ; Janssen, JAMJL,期刊：Diabetes, 页码：505-508 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-There is a complex relationship between IGF-I, IGF binding proteins, growth hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method for measuring IGF-I bioactivity in human ser...
- Engineered Zinc Finger Protein-Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes
[作者：Pawson, EJ; Duran-Jimenez, B; Surosky, R; Brooke, HE; Spratt, SK; Tomlinson, DR; Gardiner, NJ,期刊：Diabetes, 页码：509-518 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The objectives of the study were to evaluate retrograde axonal transport of vascular endothelial growth factor A (VEGF-A) protein to sensory neurons after intramuscular administration of an engineered zinc fing...
- Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation
[作者：Fioramonti, X; Marsollier, N; Song, ZT; Fakira, KA; Patel, RM; Brown, S; Duparc, T; Pica-Mendez, A; Sanders, NM; Knauf, C; Valet, P; McCrimmon, RJ; Beuve, A; Magnan, C; Routh, VH,期刊：Diabetes, 页码：519-528 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The response of ventromedial hypothalamic (VMH) glucose-inhibited neurons to decreased glucose is impaired under conditions where the counterregulatory response (CRR) to hypoglycemia is impaired (e.g., recurren...
- Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
[作者：Oudit, GY; Liu, GC; Zhong, JC; Basu, R; Chow, FL; Zhou, J; Loibner, H; Janzek, E; Schuster, M; Penninger, JM; Herzenberg, AM; Kassiri, Z; Scholey, JW,期刊：Diabetes, 页码：529-538 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Diabetic nephropathy is one of the most common causes of end-stage renal failure. Inhibition of ACE2 function accelerates diabetic kidney injury, whereas renal ACE2 is downregulated in diabetic nephropathy. We ...
- A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose
[作者：Paterson, AD; Waggott, D; Boright, AP; Hosseini, SM; Shen, EQ; Sylvestre, MP; Wong, I; Bharaj, B; Cleary, PA; Lachin, JM; Below, JE; Nicolae, D; Cox, NJ; Canty, AJ; Sun, L; Bull, SB,期刊：Diabetes, 页码：539-549 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Glycemia is a major risk factor for the development of long-term complications in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control in individuals with type 1 diabetes...
- Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
[作者：Lin, HV; Plum, L; Ono, H; Gutierrez-Juarez, R; Shanabrough, M; Borok, E; Horvath, TL; Rossetti, L; Accili, D,期刊：Diabetes, 页码：337-346 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The sites of insulin action in the central nervous system that regulate glucose metabolism and energy expenditure are incompletely characterized. We have shown that mice with hypothalamic deficiency (L1) of ins...
- Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
[作者：Huang, W; Metlakunta, A; Dedousis, N; Zhang, PL; Sipula, I; Dube, JJ; Scott, DK; O'Doherty, RM,期刊：Diabetes, 页码：347-357 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Increased activity of the innate immune system has been implicated in the pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 diabetes. In this study, we addressed the pot...
- Cytokines Interleukin-1 beta and Tumor Necrosis Factor-alpha Regulate Different Transcriptional and Alternative Splicing Networks in Primary beta-Cells
[作者：Ortis, F; Naamane, N; Flamez, D; Ladriere, L; Moore, F; Cunha, DA; Colli, ML; Thykjaer, T; Thorsen, K; Orntoft, TF; Eizirik, DL,期刊：Diabetes, 页码：358-374 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Cytokines contribute to pancreatic beta-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global...
- Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells
[作者：Lipina, C; Stretton, C; Hastings, S; Hundal, JS; Mackie, K; Irving, AJ; Hundal, HS,期刊：Diabetes, 页码：375-385 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-The endogenous cannabinoid (or endocannabinoid) system (ECS) is part of a central neuromodulatory system thought to play a key role in the regulation of feeding behavior and energy balance. However, increasing ...
- Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes Dissociation of Adipocyte Hypertrophy From Inflammation
[作者：Han, CY; Kargi, AY; Omer, M; Chan, CK; Wabitsch, M; O'Brien, KD; Wight, TN; Chait, A,期刊：Diabetes, 页码：386-396 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Obesity is associated with monocyte-macrophage accumulation in adipose tissue. Previously, we showed that glucose-stimulated production by adipocytes of serum amyloid A (SAA), monocyte chemoattractant protein (...
- Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake
[作者：Gardiner, JV; Bataveljic, A; Patel, NA; Bewick, GA; Roy, D; Campbell, D; Greenwood, HC; Murphy, KG; Hameed, S; Jethwa, PH; Ebling, FJP; Vickers, SP; Cheetham, S; Ghatei, MA; Bloom, SR; Dhillo, WS,期刊：Diabetes, 页码：397-406 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis. RESEARCH...
- Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4(+) CD25(+) Regulatory T-Cells of Type 1 Diabetic Subjects
[作者：Long, SA; Cerosaletti, K; Bollyky, PL; Tatum, M; Shilling, H; Zhang, S; Zhang, ZY; Pihoker, C; Sanda, S; Greenbaum, C; Buckner, JH,期刊：Diabetes, 页码：407-415 , 文章类型： Article，,卷期：2010年59-2]
- OBJECTIVE-In humans, multiple genes in the interleukin (IL)-2/IL-2 receptor (IL-2R) pathway are associated with type 1 diabetes. However, no link between IL-2 responsiveness and CD4(+)CD25(+)FOXP3(+) regulatory T-cells (...
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