- Cerebral Metabolic Alterations in Rats With Diabetic Ketoacidosis Effects of Treatment With Insulin and Intravenous Fluids and Effects of Bumetanide
[作者：Glaser, N; Yuen, N; Anderson, SE; Tancredi, DJ; O'Donnell, ME,期刊：Diabetes, 页码：702-709 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) in children. Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but dat...
- Association Between Raised Inflammatory Markers and Cognitive Decline in Elderly People With Type 2 Diabetes The Edinburgh Type 2 Diabetes Study
[作者：Marioni, RE; Strachan, MWJ; Reynolds, RM; Lowe, GDO; Mitchell, RJ; Fowkes, FGR; Frier, BM; Lee, AJ; Butcher, I; Rumley, A; Murray, GD; Deary, IJ; Price, JF,期刊：Diabetes, 页码：710-713 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-To determine whether circulating levels of the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha are associated with cognitive ability and estimated lifeti...
- A Central Role of RLIP76 in Regulation of Glycemic Control
[作者：Awasthi, S; Singhal, SS; Yadav, S; Singhal, J; Vatsyayan, R; Zajac, E; Luchowski, R; Borvak, J; Gryczynski, K; Awasthi, YC,期刊：Diabetes, 页码：714-725 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Pathology associated with oxidative stress frequently results in insulin resistance. Glutathione (GSH) and GSH-linked metabolism is a primary defense against oxidative stress. Electrophilic lipid alkenals, such...
- Genetic Variation at the FTO Locus Influences RBL2 Gene Expression
[作者：Jowett, JBM; Curran, JE; Johnson, MP; Carless, MA; Goring, HHH; Dyer, TD; Cole, SA; Comuzzie, AG; MacCluer, JW; Moses, EK; Blangero, J,期刊：Diabetes, 页码：726-732 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Genome-wide association studies that compare the statistical association between thousands of DNA variations and a human trait have detected 958 loci across 127 different diseases and traits. However, these sta...
- A Novel Hypomorphic PDX1 Mutation Responsible for Permanent Neonatal Diabetes With Subclinical Exocrine Deficiency
[作者：Nicolino, M; Claiborn, KC; Senee, V; Boland, A; Stoffers, DA; Julier, C,期刊：Diabetes, 页码：733-740 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Genes responsible for monogenic forms of diabetes have proven very valuable for understanding key mechanisms involved in beta-cell development and function. Genetic study of selected families is a powerful stra...
- Detailed Investigation of the Role of Common and Low-Frequency WFS1 Variants in Type 2 Diabetes Risk
[作者：Fawcett, KA; Wheeler, E; Morris, AP; Ricketts, SL; Hallmans, G; Rolandsson, O; Daly, A; Wasson, J; Permutt, A; Hattersley, AT; Glaser, B; Franks, PW; McCarthy, MI; Wareham, NJ; Sandhu, MS; Barroso, I,期刊：Diabetes, 页码：741-746 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Wolfram syndrome 1 (WFS1) single nucleotide polymorphisms (SNPs) are associated with risk of type 2 diabetes. In this study we aimed to refine this association and investigate the role of low-frequency WFS1 var...
- Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
[作者：Haupt, A; Thamer, C; Heni, M; Ketterer, C; Machann, J; Schick, F; Machicao, F; Stefan, N; Claussen, CD; Haring, HU; Fritsche, A; Staiger, H,期刊：Diabetes, 页码：747-750 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-The impact of the diabetes risk gene transcription factor 7-like 2 (TCF7L2) on body weight is unclear. As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studi...
- Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI
[作者：Zhao, JH; Bradfield, JP; Zhang, HT; Annaiah, K; Wang, K; Kim, CE; Glessner, JT; Frackelton, EC; Otieno, FG; Doran, J; Thomas, KA; Garris, M; Hou, CP; Chiavacci, RM; Li, MY; Berkowitz, RI; Hakonarson, H; Grant, SFA,期刊：Diabetes, 页码：751-755 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-A number of studies have found that BMI in early life influences the risk of developing type 2 diabetes later in life. Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide a...
- AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
[作者：Um, JH; Park, SJ; Kang, H; Yang, ST; Foretz, M; McBurney, MW; Kim, MK; Viollet, B; Chung, JH,期刊：Diabetes, 页码：554-563 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and physical endurance and reduces fat accumulation in...
- A Possible Inflammatory Role of Twist1 in Human White Adipocytes
[作者：Pettersson, AT; Laurencikiene, J; Mejhert, N; Naslund, E; Bouloumie, A; Dahlman, I; Arner, P; Ryden, M,期刊：Diabetes, 页码：564-571 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Twist1 is a transcription factor that is highly expressed in murine brown and white adipose tissue (WAT) and negatively regulates fatty acid oxidation in mice. The role of twist1 in WAT is not known and was the...
- Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity
[作者：Meex, RCR; Schrauwen-Hinderling, VB; Moonen-Kornips, E; Schaart, G; Mensink, M; Phielix, E; van de Weijer, T; Sels, JP; Schrauwen, P; Hesselink, MKC,期刊：Diabetes, 页码：572-579 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. We examined whether exercise training could restor...
- Insulin Acutely Inhibits Intestinal Lipoprotein Secretion in Humans in Part by Suppressing Plasma Free Fatty Acids
[作者：Pavlic, M; Xiao, CT; Szeto, L; Patterson, BW; Lewis, GF,期刊：Diabetes, 页码：580-587 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in humans. Here, we investigated the effect of acute hyper...
- Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice
[作者：Gonzalez-Rodriguez, A; Gutierrez, JAM; Sanz-Gonzalez, S; Ros, M; Burks, DJ; Valverde, AM,期刊：Diabetes, 页码：588-599 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice deficient for protein tyrosine phosphatas...
- Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling
[作者：Blouin, CM; Prado, C; Takane, KK; Lasnier, F; Garcia-Ocana, A; Ferre, P; Dugail, I; Hajduch, E,期刊：Diabetes, 页码：600-610 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation. In different cells, two distinct mechanisms have been proposed to mediate ceramide inh...
- Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in US Women A Prospective Study
[作者：Sun, Q; van Dam, RM; Meigs, JB; Franco, OH; Mantzoros, CS; Hu, FB,期刊：Diabetes, 页码：611-618 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex rel...
- Diet-Induced Obesity Prevents Interstitial Dispersion of Insulin in Skeletal Muscle
[作者：Kolka, CM; Harrison, LN; Lottati, M; Chiu, JD; Kirkman, EL; Bergman, RN,期刊：Diabetes, 页码：619-626 , 文章类型： Article，,卷期：2010年59-3]
- OBJECTIVE-Obesity causes insulin resistance, which has been interpreted as reduced downstream insulin signaling. However, changes in access of insulin to sensitive tissues such as skeletal muscle may also play a role. In...
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