- Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
[作者：Chakrabarti, P; English, T; Shi, J; Smas, CM; Kandror, KV,期刊：Diabetes, 页码：775-781 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-In metazoans, target of rapamycin complex 1 (TORC1) plays the key role in nutrient- and hormone-dependent control of metabolism. However, the role of TORC1 in regulation of triglyceride storage and metabolism r...
- Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes
[作者：Togliatto, G; Trombetta, A; Dentelli, P; Baragli, A; Rosso, A; Granata, R; Ghigo, D; Pegoraro, L; Ghigo, E; Brizzi, MF,期刊：Diabetes, 页码：1016-1025 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Acylated ghrelin (AG) is a diabetogenic and orexigenic gastric polypeptide. These properties are not shared by the most abundant circulating form, which is unacylated (UAG). An altered UAG/AG profile together w...
- Serum Soluble Glycoprotein 130 Concentration Is Inversely Related to Insulin Sensitivity in Women With Polycystic Ovary Syndrome
[作者：Nikolajuk, A; Kowalska, I; Karczewska-Eupczewska, M; Adamska, A; Otziomek, E; Wolczynski, S; Kinalska, I; Gorska, M; Straczkowski, M,期刊：Diabetes, 页码：1026-1029 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Insulin resistance might play a role in the pathogenesis of polycystic ovarian syndrome (PCOS). The family of glycoprotein 130 (gp130) cytokines could influence insulin action. One of these cytokines is interle...
- Insufficiency of Janus Kinase 2-Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions
[作者：Robertson, S; Ishida-Takahashi, R; Tawara, I; Hu, J; Patterson, CM; Jones, JC; Kulkarni, RN; Myers, MG,期刊：Diabetes, 页码：782-790 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes th...
- Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis
[作者：Luo, NL; Liu, J; Chung, BH; Yang, QL; Klein, RL; Garvey, WT; Fu, YC,期刊：Diabetes, 页码：791-799 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Adiponectin is one of several important metabolically active cytokines secreted from adipose tissue. Epidemiologic studies have associated low-circulating levels of this adipokine with multiple metabolic disord...
- Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4
[作者：Arakawa, M; Mita, T; Azuma, K; Ebato, C; Goto, H; Nomiyama, T; Fujitani, Y; Hirose, T; Kawamori, R; Watada, H,期刊：Diabetes, 页码：1030-1037 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonists such as an exenclin-4 has direct beneficial effects on the cardiovascular system. However, their effects on atherosclerogen...
- Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin
[作者：Rabbani, N; Chittari, MV; Bodmer, CW; Zehnder, D; Ceriello, A; Thornalley, PJ,期刊：Diabetes, 页码：1038-1045 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metform...
- Acute Inhibition of Fatty Acid Import Inhibits GLUT4 Transcription in Adipose Tissue, but Not Skeletal or Cardiac Muscle Tissue, Partly Through Liver X Receptor (LXR) Signaling
[作者：Griesel, BA; Weems, J; Russell, RA; Abel, ED; Humphries, K; Olson, AL,期刊：Diabetes, 页码：800-807 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Insulin-mediated glucose uptake is highly sensitive to the levels of the facilitative GLUT protein GLUT4. Transcription of the GLUT4 gene is repressed in states of insulin deficiency and insulin resistance and ...
- The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator-Activated Receptor delta
[作者：Riahi, Y; Sin-Malia, Y; Cohen, G; Alpert, E; Gruzman, A; Eckel, J; Staels, B; Guichardant, M; Sasson, S,期刊：Diabetes, 页码：808-818 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Vascular endothelial cells (VECs) downregulate their rate of glucose uptake in response to hyperglycemia by decreasing the expression of their typical glucose transporter GLUT-1. Hitherto, we discovered critica...
- Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy
[作者：Barutta, F; Corbelli, A; Mastrocola, R; Gambino, R; Di Marzo, V; Pinach, S; Rastaldi, MP; Perin, PC; Gruden, G,期刊：Diabetes, 页码：1046-1054 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Cannabinoid receptor 1 (CR1) is localized in the central nervous system and in peripheral tissues involved in energy metabolism control. However, CB1 receptors are also expressed at low level within the glomeru...
- Recurrent Moderate Hypoglycemia Ameliorates Brain Damage and Cognitive Dysfunction Induced by Severe Hypoglycemia
[作者：Puente, EC; Silverstein, J; Bree, AJ; Musikantow, DR; Wozniak, DF; Maloney, S; Daphna-Iken, D; Fisher, SJ,期刊：Diabetes, 页码：1055-1062 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Although intensive glycemic control achieved with insulin therapy increases the incidence of both moderate and severe hypoglycemia, clinical reports of cognitive impairment due to severe hypoglycemia have been ...
- Compensatory Increases in Nuclear PGC1 alpha Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats
[作者：Holloway, GP; Gurd, BJ; Snook, LA; Lally, J; Bonen, A,期刊：Diabetes, 页码：819-828 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-We examined in insulin-resistant muscle if, in contrast to long-standing dogma, mitochondrial fatty acid oxidation is increased and whether this is attributed to an increased nuclear content of peroxisome proli...
- SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
[作者：Rutanen, J; Yaluri, N; Modi, S; Pihlajamaki, J; Vanttinen, M; Itkonen, P; Kainulainen, S; Yamamoto, H; Lagouge, M; Sinclair, DA; Elliott, P; Westphal, C; Auwerx, J; Laakso, M,期刊：Diabetes, 页码：829-835 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in ins...
- Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice
[作者：Sauve, M; Ban, K; Momen, MA; Zhou, YQ; Henkelman, RM; Husain, M; Drucker, DJ,期刊：Diabetes, 页码：1063-1073 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-Glucagon-like peptide-1 (7-36)amide (GLP-1) is cleaved by dipeptidyl peptidase-4 (DPP-4) to GLP-1 (9-36)amide. We examined whether chemical inhibition or genetic elimination of DPP-4 activity affects cardiovasc...
- Effects of Antecedent GABA(A) Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia hi Healthy Humans
[作者：Hedrington, MS; Farmerie, S; Ertl, AC; Wang, ZH; Tate, DB; Davis, SN,期刊：Diabetes, 页码：1074-1081 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-To date, there are no data investigating the effects of GABA(A) activation on counterregulatory responses during repeated hypoglycemia in humans. The aim of this study was to determine the effects of prior GABA...
- The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest
[作者：Alibegovic, AC; Sonne, MP; Hojbjerre, L; Hansen, T; Pedersen, O; van Hall, G; Holst, JJ; Stallknecht, B; Dela, F; Vaag, A,期刊：Diabetes, 页码：836-843 , 文章类型： Article，,卷期：2010年59-4]
- OBJECTIVE-The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin re...
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