- Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
[作者:XU JIE; REUMERS JOKE; COUCEIRO JOSE R; DE SMET FREDERIK; GALLARDO RODRIGO; RUDYAK STANISLAV; CORNELIS ANN; ROZENSKI JEF; ZWOLINSKA ALEKSANDRA; MARINE JEANCHRISTOPHE; LAMBRECHTS DIETHER; SUH YOUNGAH; ROUSSEAU FREDERIC; SCHYMKOWITZ JOOST,期刊:NATURE CHEMICAL BIOLOGY, 页码:285-295 , 文章类型: Article,,卷期:2011年7-5]
- Many p53 missense mutations possess dominant-negative activity and oncogenic gain of function. We report that for structurally destabilized p53 mutants, these effects result from mutant-induced coaggregation of wild-type...
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