- A Basis for Reduced Chemical Library Inhibition of Firefly Luciferase Obtained from Directed Evolution.
[作者:Auld, Douglas S.;Zhang, Ya-Qin;Southall, Noel T.;Rai, Ganesha;Landsman, Marc;MacLure, Jennifer;Langevin, Daniel;Thomas, Craig J.;Austin, Christopher P.;Inglese, James;,期刊:Journal of Medicinal Chemistry, 页码:1450-1458 , 文章类型: 研究论文,,卷期:2009年52-5]
- We measured the "druggability" of the ATP-dependent luciferase derived from the firefly Photuris pennsylvanica that was optimized using directed evolution (Ultra-Glo, Promega). Quant. high-throughput screening (qHTS) wa...
- Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1, 2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-o ne (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor.
[作者:Li, Hui;Tatlock, John;Linton, Angelica;Gonzalez, Javier;Jewell, Tanya;Patel, Leena;Ludlum, Sarah;Drowns, Matthew;Rahavendran, Sadayappan V.;Skor, Heather;Hunter, Robert;Shi, Stephanie T.;Herlihy, Koleen J.;Parge, Hans;Hickey, Michael;Yu, Xiu;Chau, Fannie;,期刊:Journal of Medicinal Chemistry, 页码:1255-1258 , 文章类型: 研究论文,,卷期:2009年52-5]
- The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compd. aq. soly. an...
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