- Genetic variation in bone morphogenetic protein and colon and rectal cancer
[作者:Slattery, ML; Lundgreen, A; Herrick, JS; Kadlubar, S; Caan, BJ; Potter, JD; Wolff, RK,期刊:International Journal of Cancer, 页码:653-664 , 文章类型: Article,,卷期:2012年130-3]
- Bone morphogenetic proteins (BMP) are part of the TGF-beta-signaling pathway; genetic variation in these genes may be involved in colorectal cancer. In this study, we evaluated the association between genetic variation i...
- Family history of cancer and the risk of laryngeal cancer: a case-control study from Italy and Switzerland
[作者:Garavello, W; Turati, F; Bosetti, C; Talamini, R; Levi, F; Lucenteforte, E; Chiesa, F; Franceschi, S; La Vecchia, C; Negri, E,期刊:International Journal of Cancer, 页码:665-670 , 文章类型: Article,,卷期:2012年130-3]
- Only limited data is available on the relationship between family history of laryngeal and other neoplasms and laryngeal cancer risk. We investigated the issue using data from a multicentre case-control study conducted i...
- Host immune gene polymorphisms were associated with the prognosis of non-small-cell lung cancer in Chinese
[作者:Dai, JC; Hu, ZB; Dong, J; Xu, L; Pan, SY; Jiang, Y; Jin, GF; Chen, YJ; Shen, HB,期刊:International Journal of Cancer, 页码:671-676 , 文章类型: Article,,卷期:2012年130-3]
- Laboratory-based studies showed that host immune genes could influence the prognosis of non-small-cell lung cancer (NSCLC). Therefore, genetic polymorphisms in host immune genes may serve as predictors for NSCLC clinical...
- Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function
[作者:Maita, S; Yuasa, T; Tsuchiya, N; Mitobe, Y; Narita, S; Horikawa, Y; Hatake, K; Fukui, I; Kimura, S; Maekawa, T; Habuchi, T,期刊:International Journal of Cancer, 页码:677-684 , 文章类型: Article,,卷期:2012年130-3]
- We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was de...
- Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide
[作者:Jiang, Q; Rao, XY; Kim, CY; Freiser, H; Zhang, QB; Jiang, ZY; Li, GL,期刊:International Journal of Cancer, 页码:685-693 , 文章类型: Article,,卷期:2012年130-3]
- Although cell-based studies have shown that c-tocotrienol (gamma TE) exhibits stronger anticancer activities than other forms of vitamin E including c-tocopherol (gamma T), the molecular bases underlying gamma TE-exerted...
- Cytotoxic activity of the histone deacetylase inhibitor panobinostat (LBH589) in anaplastic thyroid cancer in vitro and in vivo
[作者:Catalano, MG; Pugliese, M; Gargantini, E; Grange, C; Bussolati, B; Asioli, S; Bosco, O; Poli, R; Compagnone, A; Bandino, A; Mainini, F; Fortunati, N; Boccuzzi, G,期刊:International Journal of Cancer, 页码:694-704 , 文章类型: Article,,卷期:2012年130-3]
- Anaplastic thyroid carcinoma (ATC) has a rapidly fatal clinical course, being resistant to multimodal treatments. Microtubules, alpha/beta tubulin heterodimers, are crucial in cell signaling, division and mitosis and are...
- Mechanism of cell death mediated by a BF(2)-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo
[作者:O'Connor, AE; Mc Gee, MM; Likar, Y; Ponomarev, V; Callanan, JJ; O'shea, DF; Byrne, AT; Gallagher, WM,期刊:International Journal of Cancer, 页码:705-715 , 文章类型: Article,,卷期:2012年130-3]
- Photodynamic therapy (PDT) is an established treatment modality for cancer. ADPM06 is an emerging non-porphyrin PDT agent which has been specifically designed for therapeutic application. Recently, we have demonstrated t...
- Hemin, an iron-binding porphyrin, inhibits HIF-1 alpha induction through its binding with heat shock protein 90
[作者:Lee, JM; Lee, WH; Kay, HY; Kim, ES; Moon, A; Kim, SG,期刊:International Journal of Cancer, 页码:716-727 , 文章类型: Article,,卷期:2012年130-3]
- Hypoxia and growth factor stimulation induce hypoxia-inducible factor-1 alpha (HIF-1 alpha), conferring upon cancer cells the ability to adapt to microenvironments and enhance proliferation, angiogenesis and metastasis. ...
- Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN
[作者:Pandey, V; Vijayakumar, MV; Ajay, AK; Malvi, P; Bhat, MK,期刊:International Journal of Cancer, 页码:497-508 , 文章类型: Article,,卷期:2012年130-3]
- Recent population-based epidemiological studies strongly hint towards a link between obesity and its occurrence as well as progression of several cancers including melanoma. Although effects of obesity on breast, colon a...
- MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression
[作者:Szmulewitz, RZ; Clark, R; Lotan, T; Otto, K; Veneris, JT; Macleod, K; Rinker-Schaeffer, C,期刊:International Journal of Cancer, 页码:509-520 , 文章类型: Article,,卷期:2012年130-3]
- Metastatic dissemination in prostate cancer is often early, but not all cancer cells form clinical metastases. Map kinase kinase 4 (MKK4) suppresses metastasis in a preclinical prostate cancer model. We hypothesize that ...
- The importance of integrin-linked kinase in the regulation of bladder cancer invasion
[作者:Matsui, Y; Assi, K; Ogawa, O; Raven, PA; Dedhar, S; Gleave, ME; Salh, B; So, AI,期刊:International Journal of Cancer, 页码:521-531 , 文章类型: Article,,卷期:2012年130-3]
- It is important to understand the molecular mechanisms of bladder cancer progression not only to prevent cancer progression but also to detect new therapeutic targets against advanced bladder cancer. The integrin-linked ...
- Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells
[作者:Liby, TA; Spyropoulos, P; Lindner, HB; Eldridge, J; Beeson, C; Hsu, T; Muise-Helmericks, RC,期刊:International Journal of Cancer, 页码:532-543 , 文章类型: Article,,卷期:2012年130-3]
- The PI3 kinase/Akt pathway is commonly deregulated in human cancers, functioning in such processes as proliferation, glucose metabolism, survival and motility. We have previously described a novel function for one of the...
- The novel lupus antigen related protein acheron enhances the development of human breast cancer
[作者:Shao, R; Scully, SJ; Yan, W; Bentley, B; Mueller, J; Brown, C; Bigelow, C; Schwartz, LM,期刊:International Journal of Cancer, 页码:544-554 , 文章类型: Article,,卷期:2012年130-3]
- Acheron (Achn) is a new member of the Lupus antigen family of RNA binding proteins. Previous studies have shown that Achn controls developmental decisions in neurons and muscle. In the human mammary gland, Achn expressio...
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