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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Regulation of DNA replication during development [作者：Nordman, J; Orr-Weaver, TL,期刊：Development, 页码：455-464 , 文章类型： Article，,卷期：2012年139-3] As development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk betwe... Cdx2 determines the fate of postnatal intestinal endoderm [作者：Stringer, EJ; Duluc, I; Saandi, T; Davidson, I; Bialecka, M; Sato, T; Barker, N; Clevers, H; Pritchard, CA; Winton, DJ; Wright, NA; Freund, JN; Deschamps, J; Beck, F,期刊：Development, 页码：465-474 , 文章类型： Article，,卷期：2012年139-3] Knock out of intestinal Cdx2 produces different effects depending upon the developmental stage at which this occurs. Early in development it produces histologically ordered stomach mucosa in the midgut. Conditional inact... p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex [作者：Mairet-Coello, G; Tury, A; Van Buskirk, E; Robinson, K; Genestine, M; DiCicco-Bloom, E,期刊：Development, 页码：475-487 , 文章类型： Article，,卷期：2012年139-3] During cerebral cortex development, precise control of precursor cell cycle length and cell cycle exit is required for balanced precursor pool expansion and layer-specific neurogenesis. Here, we defined the roles of cycl... Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells [作者：VanDussen, KL; Carulli, AJ; Keeley, TM; Patel, SR; Puthoff, BJ; Magness, ST; Tran, IT; Maillard, I; Siebel, C; Kolterud, A; Grosse, AS; Gumucio, DL; Ernst, SA; Tsai, YH; Dempsey, PJ; Samuelson, LC,期刊：Development, 页码：488-497 , 文章类型： Article，,卷期：2012年139-3] Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however, direct cellular targets and specific functions of Notch signals had not been identified. We sho... LACHESIS-dependent egg-cell signaling regulates the development of female gametophytic cells [作者：Volz, R; von Lyncker, L; Baumann, N; Dresselhaus, T; Sprunck, S; Gross-Hardt, R,期刊：Development, 页码：498-502 , 文章类型： Article，,卷期：2012年139-3] In contrast to animals, plant germ cells are formed along with accessory cells in specialized haploid generations, termed gametophytes. The female gametophyte of flowering plants consists of four different cell types, wh... Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells [作者：Guilgur, LG; Prudencio, P; Ferreira, T; Pimenta-Marques, AR; Martinho, RG,期刊：Development, 页码：503-513 , 文章类型： Article，,卷期：2012年139-3] Epithelial cells mostly orient the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells. The correct orientation of the spindle relies on the interaction betw... Wnt/beta-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle [作者：Caron, A; Xu, XL; Lin, XY,期刊：Development, 页码：514-524 , 文章类型： Article，,卷期：2012年139-3] Cilia are essential for normal development. The composition and assembly of cilia has been well characterized, but the signaling and transcriptional pathways that govern ciliogenesis remain poorly studied. Here, we repor... Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways [作者：Dworkin, S; Darido, C; Georgy, SR; Wilanowski, T; Srivastava, S; Ellett, F; Pase, L; Han, YC; Meng, AM; Heath, JK; Lieschke, GJ; Jane, SM,期刊：Development, 页码：525-536 , 文章类型： Article，,卷期：2012年139-3] The isthmic organiser located at the midbrain-hindbrain boundary (MHB) is the crucial developmental signalling centre responsible for patterning mesencephalic and metencephalic regions of the vertebrate brain. Formation ... alpha E-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly [作者：Schepis, A; Sepich, D; Nelson, WJ,期刊：Development, 页码：537-546 , 文章类型： Article，,卷期：2012年139-3] alpha E-catenin is an actin-binding protein associated with the E-cadherin-based adherens junction that regulates cell-cell adhesion. Recent studies identified additional E-cadherin-independent roles of alpha E-catenin i... CycA is involved in the control of endoreplication dynamics in the Drosophila bristle lineage [作者：Salle, J; Campbell, SD; Gho, M; Audibert, A,期刊：Development, 页码：547-557 , 文章类型： Article，,卷期：2012年139-3] Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of termin... Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila [作者：Yamakawa, T; Yamada, K; Sasamura, T; Nakazawa, N; Kanai, M; Suzuki, E; Fortini, ME; Matsuno, K,期刊：Development, 页码：558-567 , 文章类型： Article，,卷期：2012年139-3] The Notch (N) signaling machinery is evolutionarily conserved and regulates a broad spectrum of cell-specification events, through local cell-cell communication. pecanex (pcx) encodes a multi-pass transmembrane protein o... DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress [作者：Kim, B; Cooke, HJ; Rhee, K,期刊：Development, 页码：568-578 , 文章类型： Article，,卷期：2012年139-3] Mammalian male germ cells should be maintained below body temperature for proper development. Here, we investigated how male germ cells respond to heat stress. A short exposure of mouse testes to core body temperature in... The genomic regulatory control of skeletal morphogenesis in the sea urchin [作者：Rafiq, K; Cheers, MS; Ettensohn, CA,期刊：Development, 页码：579-590 , 文章类型： Article，,卷期：2012年139-3] A central challenge of developmental and evolutionary biology is to understand how anatomy is encoded in the genome. Elucidating the genetic mechanisms that control the development of specific anatomical features will re... Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons [作者：Pan, YA; Choy, M; Prober, DA; Schier, AF,期刊：Development, 页码：591-600 , 文章类型： Article，,卷期：2012年139-3] How neurons connect to form functional circuits is central to the understanding of the development and function of the nervous system. In the somatosensory system, perception of sensory stimuli to the head requires speci... Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh [作者：Wang, WG; Lian, N; Ma, Y; Li, LZ; Gallant, RC; Elefteriou, F; Yang, XL,期刊：Development, 页码：601-611 , 文章类型： Article，,卷期：2012年139-3] Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the... The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation [作者：Carroll, CE; Marada, S; Stewart, DP; Ouyang, JXX; Ogden, SK,期刊：Development, 页码：612-621 , 文章类型： Article，,卷期：2012年139-3] The Hedgehog (Hh) signaling pathway plays an instructional role during development, and is frequently activated in cancer. Ligand-induced pathway activation requires signaling by the transmembrane protein Smoothened (Smo...