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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila [作者：Benmimoun, B; Polesello, C; Waltzer, L; Haenlin, M,期刊：Development, 页码：1713-1717 , 文章类型： Article，,卷期：2012年139-10] The interconnected Insulin/IGF signaling (IlS) and Target of Rapamycin (TOR) signaling pathways constitute the main branches of the nutrient-sensing system that couples growth to nutritional conditions in Drosophila. Her... Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation [作者：Hindley, C; Ali, F; McDowell, G; Cheng, K; Jones, A; Guillemot, F; Philpott, A,期刊：Development, 页码：1718-1723 , 文章类型： Article，,卷期：2012年139-10] Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD, while simultaneously controlling progenitor maintenance non-cell-autonomously by upregulati... WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum [作者：Pei, YX; Brun, SN; Markant, SL; Lento, W; Gibson, P; Taketo, MM; Giovannini, M; Gilbertson, RJ; Wechsler-Reya, RJ,期刊：Development, 页码：1724-1733 , 文章类型： Article，,卷期：2012年139-10] The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT pathway mutations are associated with medulloblastoma, the most common malignant b... FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation [作者：Ishii, K; Kanatsu-Shinohara, M; Toyokuni, S; Shinohara, T,期刊：Development, 页码：1734-1743 , 文章类型： Article，,卷期：2012年139-10] Fibroblast growth factor 2 (FGF2) and glial cell line-derived neurotrophic factor (GDNF) are required to recapitulate spermatogonial stem cell (SSC) self-renewal in vitro. Although studies have revealed the role of the G... Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells [作者：Afelik, S; Qu, XL; Hasrouni, E; Bukys, MA; Deering, T; Nieuwoudt, S; Rogers, W; MacDonald, RJ; Jensen, J,期刊：Development, 页码：1744-1753 , 文章类型： Article，,卷期：2012年139-10] Early pancreatic morphogenesis is characterized by the transformation of an uncommitted pool of pancreatic progenitor cells into a branched pancreatic epithelium that consists of 'tip' and 'trunk' domains. These domains ... p120-catenin is essential for terminal end bud function and mammary morphogenesis [作者：Kurley, SJ; Bierie, B; Carnahan, RH; Lobdell, NA; Davis, MA; Hofmann, I; Moses, HL; Muller, WJ; Reynolds, AB,期刊：Development, 页码：1754-1764 , 文章类型： Article，,卷期：2012年139-10] Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems reveal markedly different effects. Here, we examine for the first time the conseque... The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity [作者：Rodrigues, F; Thuma, L; Klambt, C,期刊：Development, 页码：1765-1776 , 文章类型： Article，,卷期：2012年139-10] The differentiation of the blood-brain barrier (BBB) is an essential process in the development of a complex nervous system and depends on alternative splicing. In the fly BBB, glial cells establish intensive septate jun... The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle [作者：Stooke-Vaughan, GA; Huang, P; Hammond, KL; Schier, AF; Whitfield, TT,期刊：Development, 页码：1777-1787 , 文章类型： Article，,卷期：2012年139-10] Otoliths are biomineralised structures required for the sensation of gravity, linear acceleration and sound in the zebrafish ear. Otolith precursor particles, initially distributed throughout the otic vesicle lumen, beco... Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function [作者：Chawla, G; Sokol, NS,期刊：Development, 页码：1788-1797 , 文章类型： Article，,卷期：2012年139-10] Steroid hormones and their nuclear receptors drive developmental transitions in diverse organisms, including mammals. In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear re... A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor [作者：Zarin, AA; Daly, AC; Holsmeier, J; Asadzadeh, J; Labrador, JP,期刊：Development, 页码：1798-1805 , 文章类型： Article，,卷期：2012年139-10] Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly und... Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity [作者：Saburi, S; Hester, I; Goodrich, L; McNeill, H,期刊：Development, 页码：1806-1820 , 文章类型： Article，,卷期：2012年139-10] The atypical cadherin fat (ft) was originally discovered as a tumor suppressor in Drosophila and later shown to regulate a form of tissue patterning known as planar polarity. In mammals, four ft homologs have been identi... Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development [作者：Jin, YR; Han, XH; Taketo, MM; Yoon, JK,期刊：Development, 页码：1821-1830 , 文章类型： Article，,卷期：2012年139-10] Outgrowth and fusion of the lateral and medial nasal processes and of the maxillary process of the first branchial arch are integral to lip and primary palate development. Wnt9b mutations are associated with cleft lip an... Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development [作者：John, A; Brylka, H; Wiegreffe, C; Simon, R; Liu, PT; Juttner, R; Crenshaw, EB; Luyten, FP; Jenkins, NA; Copeland, NG; Birchmeier, C; Britsch, S,期刊：Development, 页码：1831-1841 , 文章类型： Article，,卷期：2012年139-10] Dorsal spinal cord neurons receive and integrate somatosensory information provided by neurons located in dorsal root ganglia. Here we demonstrate that dorsal spinal neurons require the Kruppel-(CH2)-H-2 zinc-finger tran... A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly [作者：Rotureau, B; Subota, I; Buisson, J; Bastin, P,期刊：Development, 页码：1842-1850 , 文章类型： Article，,卷期：2012年139-10] African trypanosomes are flagellated protozoan parasites that cause sleeping sickness and are transmitted by the bite of the tsetse fly. To complete their life cycle in the insect, trypanosomes reach the salivary glands ... The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1 [作者：Carberry, K; Wiesenfahrt, T; Geisler, F; Stocker, S; Gerhardus, H; Uberbach, D; Davis, W; Jorgensen, E; Leube, RE; Bossinger, O,期刊：Development, 页码：1851-1862 , 文章类型： Article，,卷期：2012年139-10] The nematode Caenorhabditis elegans is an excellent model system in which to study in vivo organization and function of the intermediate filament (IF) system for epithelial development and function. Using a transgenic if... Identification of molecular compartments and genetic circuitry in the developing mammalian kidney [作者：Yu, J; Valerius, MT; Duah, M; Staser, K; Hansard, JK; Guo, JJ; McMahon, J; Vaughan, J; Faria, D; Georgas, K; Rumballe, B; Ren, Q; Krautzberger, AM; Junker, JP; Thiagarajan, RD; Machanick, P; Gray, PA; van Oudenaarden, A; Rowitch, DH; Stiles, CD; Ma, QF; Grimmond, SM; Bailey, TL; Little, MH; McMahon, AP,期刊：Development, 页码：1863-1873 , 文章类型： Article，,卷期：2012年139-10] Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cel...