- Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
[作者:ELSAYED MAGDA A A; ABDELAZIZ NAGLAA I; ABDELAZIZ ALAA A M; ELAZAB ADEL S; ASIRI YOUSIF A; ELTAHIR KAMAL E H,期刊:Bioorganic & Medicinal Chemistry, 页码:3416-3424 , 文章类型: Article,,卷期:2011年19-11]
- New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4-trifuorobutane-1,3-dione 1. The newly synthesized compounds were investigated in vivo for t...
- Synthesis and biological evaluation of loxoprofen derivatives
[作者:YAMAKAWA NAOKI; SUEMASU SHINTARO; MATOYAMA MASAAKI; TANAKA KENICHIRO; KATSU TAKASHI; MIYATA KEISHI; OKAMOTO YOSHINARI; OTSUKA MASAMI; MIZUSHIMA TOHRU,期刊:Bioorganic & Medicinal Chemistry, 页码:3299-3311 , 文章类型: Article,,卷期:2011年19-11]
- Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX acti...
- Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles
[作者:KHOJE ABHIJIT DATTA; CHARNOCK COLIN; WAN BAOJIE; FRANZBLAU SCOTT; GUNDERSEN LISELOTTE,期刊:Bioorganic & Medicinal Chemistry, 页码:3483-3491 , 文章类型: Article,,卷期:2011年19-11]
- 6,9-Disubstituted purines and 7-deazapurines are known to be powerful inhibitors of Mycobacterium tuberculosis (Mtb) in vitro. Analogs modified in the six-membered ring (imidazopyridines, pyrrolopyridines, benzimidazoles...
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