- Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models
[作者:Otte, A; Sauter, M; Alleva, L; Baumgarte, S; Klingel, K; Gabriel, G,期刊:American Journal of Pathology, 页码:230-239 , 文章类型: Article,,卷期:2011年179-1]
- Influenza viruses are responsible for high morbidities in humans and may, eventually, cause pandemics. Herein, we compared the pathogenesis and host innate immune responses of a seasonal H1N1, two 2009 pandemic H1N1, and...
- Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury
[作者:Radi, ZA; Koza-Taylor, PH; Bell, RR; Obert, LA; Runnels, HA; Beebe, JS; Lawton, MP; Sadis, S,期刊:American Journal of Pathology, 页码:240-247 , 文章类型: Article,,卷期:2011年179-1]
- Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that is responsible for the survival and proliferation of monocytes and the differentiation of monocytes into macrophages, including Kupffer c...
- IL-17-Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease
[作者:Mukherjee, S; Lindell, DM; Berlin, AA; Morris, SB; Shanley, TP; Hershenson, MB; Lukacs, NW,期刊:American Journal of Pathology, 页码:248-258 , 文章类型: Article,,卷期:2011年179-1]
- Severe respiratory syncytial virus (RSV) infections are characterized by airway epithelial cell damage, mucus hypersecretion, and Th2 cytokine production. Less is known about the role of IL-17. We observed increased IL-6...
- The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties
[作者:Montero-Melendez, T; Patel, HB; Seed, M; Nielsen, S; Jonassen, TEN; Perretti, M,期刊:American Journal of Pathology, 页码:259-269 , 文章类型: Article,,卷期:2011年179-1]
- Synthetic and natural melanocortin (MC) peptides afford inhibitory properties in inflammation and tissue injury, but characterization of receptor involvement is still elusive. We used the agonist AP214 to test MC-depende...
- Low-Dose Exposure of C57BL/6 Mice to Burkholderia pseudomallei Mimics Chronic Human Melioidosis
[作者:Conejero, L; Patel, N; de Reynal, M; Oberdorf, S; Prior, J; Felgner, PL; Titball, RW; Salguero, FJ; Bancroft, GJ,期刊:American Journal of Pathology, 页码:270-280 , 文章类型: Article,,卷期:2011年179-1]
- Burkholderia pseudomallei is the etiological agent of human melioidosis, a disease with a broad spectrum of clinical manifestations ranging from fatal septicemia to chronic localized infection or asymptomatic latent infe...
- Cavia porcellus as a Model for Experimental Infection by Trypanosoma cruzi
[作者:Castro-Sesquen, YE; Gilman, RH; Yauri, V; Angulo, N; Verastegui, M; Velasquez, DE; Sterling, CR; Martin, D; Bern, C,期刊:American Journal of Pathology, 页码:281-288 , 文章类型: Article,,卷期:2011年179-1]
- The guinea pig (Cavia porcellus) is a natural reservoir for Trypanosoma cruzi but has seldom been used as an experimental infection model. We developed a guinea pig infection model for acute and chronic Chagas disease. S...
- Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology
[作者:Subbian, S; Tsenova, L; O'Brien, P; Yang, G; Koo, MS; Peixoto, B; Fallows, D; Zeldis, JB; Muller, G; Kaplan, G,期刊:American Journal of Pathology, 页码:289-301 , 文章类型: Article,,卷期:2011年179-1]
- Tuberculosis (TB) is responsible for significant morbidity and mortality worldwide. Even after successful microbiological cure of TB, many patients are left with residual pulmonary damage that can lead to chronic respira...
- Pathogenesis of Influenza A/H5N1 Virus Infection in Ferrets Differs between Intranasal and Intratracheal Routes of Inoculation
[作者:Bodewes, R; Kreijtz, JHCM; van Amerongen, G; Fouchier, RAM; Osterhaus, ADME; Rimmelzwaan, GF; Kuiken, T,期刊:American Journal of Pathology, 页码:30-36 , 文章类型: Article,,卷期:2011年179-1]
- Most patients infected with highly pathogenic avian influenza A/H5N1 virus develop severe pneumonia resulting in acute respiratory distress syndrome, with extrarespiratory disease as an uncommon complication. Intranasal ...
- Dual Functions of Prostaglandin D2 in Murine Contact Hypersensitivity via DP and CRTH2
[作者:Yamamoto, Y; Otani, S; Hirai, H; Nagata, K; Aritake, K; Urade, Y; Narumiya, S; Yokozeki, H; Nakamura, M; Satoh, T,期刊:American Journal of Pathology, 页码:302-314 , 文章类型: Article,,卷期:2011年179-1]
- Prostaglandin D2 (PGD2) exerts its effects through two distinct receptors: the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and the D prostanoid (DP) receptor. Our previous study demonstrat...
- Time-Course and Regional Analyses of the Physiopathological Changes Induced after Cerebral Injection of an Amyloid beta Fragment in Rats
[作者:Zussy, C; Brureau, A; Delair, B; Marchal, S; Keller, E; Ixart, G; Naert, G; Meunier, J; Chevallier, N; Maurice, T; Givalois, L,期刊:American Journal of Pathology, 页码:315-334 , 文章类型: Article,,卷期:2011年179-1]
- Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss. The major component of senile plaques is a...
- Bmp6 Regulates Retinal Iron Homeostasis and Has Altered Expression in Age-Related Macular Degeneration
[作者:Hadziahmetovic, M; Song, Y; Wolkow, N; Lacovelli, J; Kautz, L; Roth, MP; Dunaief, JL,期刊:American Journal of Pathology, 页码:335-348 , 文章类型: Article,,卷期:2011年179-1]
- Iron-induced oxidative stress causes hereditary macular degeneration in patients with aceruloplastninemia. Similarly, retinal iron accumulation in age-related macular degeneration (AMD) may exacerbate the disease. The ca...
- Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
[作者:Ramaprakash, H; Shibata, T; Duffy, KE; Ismailoglu, UB; Bredernitz, RM; Moreira, AP; Coelho, AL; Das, AM; Fursov, N; Chupp, GL; Hogaboam, CM,期刊:American Journal of Pathology, 页码:104-115 , 文章类型: Article,,卷期:2011年179-1]
- IL-33 and its soluble receptor and cell-associated receptor (ST2L) are all increased in clinical and experimental asthma. The present study addressed the hypothesis that ST2L impairs the therapeutic effects of CpG in a f...
- Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease
[作者:Darisipudi, MN; Kulkarni, OP; Sayyed, SG; Ryu, M; Migliorini, A; Sagrinati, C; Parente, E; Vater, A; Eulberg, D; Klussmann, S; Romagnani, P; Anders, HJ,期刊:American Journal of Pathology, 页码:116-124 , 文章类型: Article,,卷期:2011年179-1]
- Monocyte/chemoattractant protein-l/chemokine ligand (CCL) 2 and stromal cell derived factor-1/CXCL12 both contribute to glomerulosclerosis in mice with type 2 diabetes mellitus, through different mechanisms. CCL2 mediate...
- Restoring Dystrophin Expression in Duchenne Muscular Dystrophy Muscle Progress in Exon Skipping and Stop Codon Read Through
[作者:Hoffman, EP; Bronson, A; Levin, AA; Takeda, S; Yokota, T; Baudy, AR; Connor, EM,期刊:American Journal of Pathology, 页码:12-22 , 文章类型: Review,,卷期:2011年179-1]
- The identification of the Duchenne muscular dystrophy gene and protein in the late 1980s led to high hopes of rapid translation to molecular therapeutics. These hopes were fueled by early reports of delivering new functi...
- Lung-Targeted Overexpression of the NF-kappa B Member RelB Inhibits Cigarette Smoke-Induced Inflammation
[作者:McMillan, DH; Baglole, CJ; Thatcher, TH; Maggirwar, S; Sime, PJ; Phipps, RP,期刊:American Journal of Pathology, 页码:125-133 , 文章类型: Article,,卷期:2011年179-1]
- Acute lung inflammation can be caused by a variety of respirable agents, including cigarette smoke. Longterm cigarette smoke exposure can cause chronic obstructive pulmonary disease (COPD), a serious illness that affects...
- AP-1 Transcription Factor JunD Confers Protection from Accelerated Nephrotoxic Nephritis and Control Podocyte-Specific Vegfa Expression
[作者:Cook, HT; Tarzi, R; D'Souza, Z; Laurent, G; Lin, WC; Aitman, TJ; Mechta-Grigoriou, F; Behmoaras, J,期刊:American Journal of Pathology, 页码:134-140 , 文章类型: Article,,卷期:2011年179-1]
- Genetic investigation of crescentic glomerulonephritis (Crgn) susceptibility in the Wistar Kyoto rat, a strain uniquely susceptible to nephrotoxic nephritis (NTN), allowed us to positionally clone the activator protein-1...
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