- Muc-2-Deficient Mice Display a Sex-Specific, COX-2-Related Impairment of Gastric Mucosal Repair
[作者:Wallace, JL; Vong, L; Dharmani, P; Srivastava, V; Chadee, K,期刊:American Journal of Pathology, 页码:1126-1133 , 文章类型: Article,,卷期:2011年178-3]
- Mucus is known to contribute significantly to the prevention and repair of mucosal damage throughout the gastrointestinal tract. Although not normally expressed in the stomach, mucin-2 (MUC-2, encoded by the MUC2 gene) i...
- Discoidin Domain Receptor 1 Isoform Expression and Potential Functions in Cirrhotic Human Liver
[作者:Song, SM; Shackel, NA; Wang, XM; Ajami, K; McCaughan, GW; Gorrell, MD,期刊:American Journal of Pathology, 页码:1134-1144 , 文章类型: Article,,卷期:2011年178-3]
- Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and is activated by collagens. Transcriptional profiling of cirrhosis in human liver using a DNA array and quantitative PCR detected elevated mR...
- Down-Regulation of Methylthioadenosine Phosphorylase (MTAP) Induces Progression of Hepatocellular Carcinoma via Accumulation of 5 '-Deoxy-5 '-Methylthioadenosine (MTA)
[作者:Kirovski, G; Stevens, AP; Czech, B; Dettmer, K; Weiss, TS; Wild, P; Hartmann, A; Bosserhoff, AK; Oefner, PJ; Hellerbrand, C,期刊:American Journal of Pathology, 页码:1145-1152 , 文章类型: Article,,卷期:2011年178-3]
- Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at inv...
- beta-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPAR gamma Pathway
[作者:Bento, AF; Marcon, R; Dutra, RC; Claudino, RF; Cola, M; Leite, DFP; Calixto, JB,期刊:American Journal of Pathology, 页码:1153-1166 , 文章类型: Article,,卷期:2011年178-3]
- Cannabinoid receptor 2 (CB2) activation is suggested to trigger the peroxisome proliferator-activated receptor-gamma (PPAR gamma) pathway, and agonists of both receptors improve colitis. Recently, the plant metabolite (E...
- gamma delta T Cells Attenuate Bleomycin-Induced Fibrosis through the Production of CXCL10
[作者:Pociask, DA; Chen, K; Choi, SM; Oury, TD; Steele, C; Kolls, JK,期刊:American Journal of Pathology, 页码:1167-1176 , 文章类型: Article,,卷期:2011年178-3]
- gamma delta T cells are a subset of T cells associated with epithelial mucosal tissues and play a prominent role in both promoting and dampening inflammatory responses to pathogens; in addition, they strongly mediate epi...
- Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia
[作者:Nadeem, L; Munir, S; Fu, GD; Dunk, C; Baczyk, D; Caniggia, I; Lye, S; Peng, C,期刊:American Journal of Pathology, 页码:1177-1189 , 文章类型: Article,,卷期:2011年178-3]
- Trophoblast cell invasion into the uterus is an essential process for successful pregnancy, and shallow invasion of trophoblasts into the maternal decidua is linked to preeclampsia. We have reported that Nodal, a member ...
- Chemokine Receptor CXCR2 Mediates Bacterial Clearance Rather Than Neutrophil Recruitment in a Murine Model of Pneumonic Plague
[作者:Eisele, NA; Lee-Lewis, H; Besch-Williford, C; Brown, CR; Anderson, DM,期刊:American Journal of Pathology, 页码:1190-1200 , 文章类型: Article,,卷期:2011年178-3]
- Pulmonary infection by Yersinia pestis causes pneumonic plague, a necrotic bronchopneumonia that is rapidly lethal and highly contagious. Acute pneumonic plague accompanies the up-regulation of pro-inflammatory cytokines...
- Endogenous Galectin-1 and Acute Inflammation Emerging Notion of a Galectin-9 Pro-Resolving Effect
[作者:Iqbal, AJ; Sampaio, ALF; Maione, F; Greco, KV; Niki, T; Hirashima, M; Perretti, M; Cooper, D,期刊:American Journal of Pathology, 页码:1201-1209 , 文章类型: Article,,卷期:2011年178-3]
- The role of endogenous galectin-1 (Gal-1) in acute inflammation has been poorly investigated. We therefore performed the carrageenan-induced paw edema model in wild-type and Gal-1(-/-) mice. On subplantar injection of ca...
- Inhibition of Transforming Growth Factor beta Worsens Elastin Degradation in a Murine Model of Kawasaki Disease
[作者:Alvira, CM; Guignabert, C; Kim, YM; Chen, CH; Wang, LL; Duong, TT; Yeung, RSM; Li, DY; Rabinovitch, M,期刊:American Journal of Pathology, 页码:1210-1220 , 文章类型: Article,,卷期:2011年178-3]
- Kawasaki disease (KD) is an acute inflammatory illness marked by coronary arteritis. However, the factors increasing susceptibility to coronary artery lesions are unknown. Because transforming growth factor (TGF) beta in...
- Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
[作者:Conklin, MW; Eickhoff, JC; Riching, KM; Pehlke, CA; Eliceiri, KW; Provenzano, PP; Friedl, A; Keely, PJ,期刊:American Journal of Pathology, 页码:1221-1232 , 文章类型: Article,,卷期:2011年178-3]
- Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. We have performed a rigorous examination of the relationship of a tumor-associated colla...
- Molecular Mechanisms of Bladder Outlet Obstruction in Transgenic Male Mice Overexpressing Aromatase (Cyp19a1)
[作者:Lin, W; Rahman, NA; Lin, JA; Zhang, H; Gou, KM; Yu, WP; Zhu, DH; Li, N; Huhtaniemi, I; Li, XD,期刊:American Journal of Pathology, 页码:1233-1244 , 文章类型: Article,,卷期:2011年178-3]
- We investigated the etiology and molecular mechanisms of bladder outlet obstruction (BOO). Transgenic (Tg) male mice overexpressing aromatase (cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57B1/6j ...
- Albuminuria and Glomerular Damage in Mice Lacking the Metabotropic Glutamate Receptor 1
[作者:Puliti, A; Rossi, PIA; Caridi, G; Corbelli, A; Ikehata, M; Armelloni, S; Li, M; Zennaro, C; Conti, V; Vaccari, CM; Cassanello, M; Calevo, MG; Emionite, L; Ravazzolo, R; Rastaldi, MP,期刊:American Journal of Pathology, 页码:1257-1269 , 文章类型: Article,,卷期:2011年178-3]
- The metabotropic glutamate (mGlu) receptor 1 (GRM1) has been shown to play an important role in neuronal cells by triggering, through calcium release from intracellular stores, various signaling pathways that finally mod...
- Impaired Vibration of Auditory Ossicles in Osteopetrotic Mice
[作者:Kanzaki, S; Takada, Y; Niida, S; Takeda, Y; Udagawa, N; Ogawa, K; Nango, N; Momose, A; Matsuo, K,期刊:American Journal of Pathology, 页码:1270-1278 , 文章类型: Article,,卷期:2011年178-3]
- In the middle ear, a chain of three tiny bones (ie, malleus, incus, and stapes) vibrates to transmit sound from the tympanic membrane to the inner ear. Little is known about whether and how bone-resorbing osteoclasts pla...
- M2 Polarized Macrophages and Giant Cells Contribute to Myofibrosis in Neuromuscular Sarcoidosis
[作者:Prokop, S; Heppner, FL; Goebel, HH; Stenzel, W,期刊:American Journal of Pathology, 页码:1279-1286 , 文章类型: Article,,卷期:2011年178-3]
- The etiopathogenesis of sarcoidosis, a systemic granulomatous disease, still remains obscure. A multitude of organs have been described to be affected in systemic sarcoidosis. Skeletal muscles may also be affected, leadi...
- Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
[作者:Pistilli, EE; Bogdanovich, S; Goncalves, MD; Ahima, RS; Lachey, J; Seehra, J; Khurana, T,期刊:American Journal of Pathology, 页码:1287-1297 , 文章类型: Article,,卷期:2011年178-3]
- The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth factor-a superfamily members, including myostatin, that are involved in the negative regulation of skeletal muscle mass. We test...
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