- Extensive X-linked adaptive evolution in central chimpanzees
[作者:Hvilsom, C; Qian, Y; Bataillon, T; Li, YR; Mailund, T; Salle, B; Carlsen, F; Li, RQ; Zheng, HC; Jiang, T; Jiang, H; Jin, X; Munch, K; Hobolth, A; Siegismund, HR; Wang, J; Schierup, MH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2054-2059 , 文章类型: Article,,卷期:2012年109-6]
- Surveying genome-wide coding variation within and among species gives unprecedented power to study the genetics of adaptation, in particular the proportion of amino acid substitutions fixed by positive selection. Additio...
- Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms
[作者:Amos-Landgraf, JM; Irving, AA; Hartman, C; Hunter, A; Laube, B; Chen, XD; Clipson, L; Newton, MA; Dove, WF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2060-2065 , 文章类型: Article,,卷期:2012年109-6]
- Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of th...
- Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
[作者:Shime, H; Matsumoto, M; Oshiumi, H; Tanaka, S; Nakane, A; Iwakura, Y; Tahara, H; Inoue, N; Seya, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2066-2071 , 文章类型: Article,,卷期:2012年109-6]
- Smoldering inflammation often increases the risk of progression for malignant tumors and simultaneously matures myeloid dendritic cells (mDCs) for cell-mediated immunity. PolyI:C, a dsRNA analog, is reported to induce in...
- Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination
[作者:Olvera-Gomez, I; Hamilton, SE; Xiao, ZG; Guimaraes, CP; Ploegh, HL; Hogquist, KA; Wang, LC; Jameson, SC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2072-2077 , 文章类型: Article,,卷期:2012年109-6]
- The ability to induce humoral and cellular immunity via antigen delivery through the unbroken skin (epicutaneous immunization, EPI) has immediate relevance for vaccine development. However, it is unclear which adjuvants ...
- Three differentiation states risk-stratify bladder cancer into distinct subtypes
[作者:Volkmer, JP; Sahoo, D; Chin, RK; Ho, PL; Tang, C; Kurtova, AV; Willingham, SB; Pazhanisamy, SK; Contreras-Trujillo, H; Storm, TA; Lotan, Y; Beck, AH; Chung, BI; Alizadeh, AA; Godoy, G; Lerner, SP; van de Rijng, M; Shortliffe, LD; Weissman, IL; Chan, KS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2078-2083 , 文章类型: Article,,卷期:2012年109-6]
- Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and grade. We investigated whether a molecular classification of tumor cell differentiation, based on a developmental biology approa...
- Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema
[作者:Lucas, R; Sridhar, S; Rick, FG; Gorshkov, B; Umapathy, NS; Yang, G; Oseghale, A; Verin, AD; Chakraborty, T; Matthay, MA; Zemskov, EA; White, R; Block, NL; Schally, AV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2084-2089 , 文章类型: Article,,卷期:2012年109-6]
- Aggressive treatment with antibiotics in patients infected with Streptococcus pneumoniae induces release of the bacterial virulence factor pneumolysin (PLY). Days after lungs are sterile, this pore-forming toxin can stil...
- Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction
[作者:Ma, LM; Yang, YJ; Sikka, SC; Kadowitz, PJ; Ignarro, LJ; Abdel-Mageed, AB; Hellstrom, WJG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2090-2095 , 文章类型: Article,,卷期:2012年109-6]
- Porcine small intestinal submucosa (SIS) has been widely used in tunica albuginea (TA) reconstructive surgery. Adipose tissue-derived stem cells (ADSCs) can repair damaged tissue, augment cellular differentiation, and st...
- Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner
[作者:Wawra, S; Bain, J; Durward, E; de Bruijn, I; Minor, KL; Matena, A; Lobach, L; Whisson, SC; Bayer, P; Porter, AJ; Birch, PRJ; Secombes, CJ; van West, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2096-2101 , 文章类型: Article,,卷期:2012年109-6]
- The eukaryoticoomycetes, or water molds, contain several species that are devastating pathogens of plants and animals. During infection, oomycetes translocate effector proteins into host cells, where they interfere with ...
- Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid
[作者:Cox, G; Thompson, GS; Jenkins, HT; Peske, F; Savelsbergh, A; Rodnina, MV; Wintermeyer, W; Homans, SW; Edwards, TA; O'Neill, AJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2102-2107 , 文章类型: Article,,卷期:2012年109-6]
- Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC). These proteins bind to elongation factor G (EF-G), the targ...
- Predictable and efficient carbon sequestration in the North Pacific Ocean supported by symbiotic nitrogen fixation
[作者:Karl, DM; Church, MJ; Dore, JE; Letelier, RM; Mahaffey, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:1842-1849 , 文章类型: Article,,卷期:2012年109-6]
- The atmospheric and deep sea reservoirs of carbon dioxide are linked via physical, chemical, and biological processes. The last of these include photosynthesis, particle settling, and organic matter remineralization, and...
|