- Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of beta-glucuronidase in tumors
[作者:Huang, PT; Chen, KC; Prijovich, ZM; Cheng, TL; Leu, YL; Roffler, SR,期刊:Cancer gene therapy, 页码:381-389 , 文章类型: Article,,卷期:2011年18-6]
- CPT-11 is a clinically important prodrug that requires conversion into the active metabolite SN-38, a potent topoisomerase I poison, for antitumor activity. However, SN-38 is rapidly metabolized to the inactive SN-38 glu...
- The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target
[作者:Ong, HT; Tan, PK; Wang, SM; Low, DTH; Ooi, LLP; Hui, KM,期刊:Cancer gene therapy, 页码:399-406 , 文章类型: Article,,卷期:2011年18-6]
- Vascular invasion is one of the clinicopathologic features that are associated with early recurrence of human hepatocellular carcinoma (HCC). In this study, we have employed high-density Affymetrix oligonucleotide GeneCh...
- Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models
[作者:Liu, Y; Tuve, S; Persson, J; Beyer, I; Yumul, R; Li, ZY; Tragoolpua, K; Hellstrom, KE; Roffler, S; Lieber, A,期刊:Cancer gene therapy, 页码:407-418 , 文章类型: Article,,卷期:2011年18-6]
- Tumor-associated antigens (TAAs) include overexpressed self-antigens (for example, Her2/neu) and tumor virus antigens (for example, HPV-16 E6/E7). Although in cancer patients, TAA-specific CD4+ and CD8+ cells are often p...
- Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma
[作者:Malla, RR; Gopinath, S; Gondi, CS; Alapati, K; Dinh, DH; Gujrati, M; Rao, JS,期刊:Cancer gene therapy, 页码:419-434 , 文章类型: Article,,卷期:2011年18-6]
- Angiogenesis, which is the process of sprouting of new blood vessels from pre-existing vessels, is vital for tumor progression. Proteolytic remodeling of extracellular matrix is a key event in vessel sprouting during ang...
- Docetaxel plus trans-tracheal injection of adenoviral-mediated p53 versus docetaxel alone in patients with previously treated non-small-cell lung cancer
[作者:Ning, X; Sun, Z; Wang, Y; Zhou, J; Chen, S; Chen, D; Zhang, H,期刊:Cancer gene therapy, 页码:444-449 , 文章类型: Article,,卷期:2011年18-6]
- This phase II clinical trial compared the efficacy and safety of two types of treatment in patients with non-small-cell lung cancer (NSCLC) who had previously been treated with chemotherapy. Patients diagnosed with NSCLC...
- RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells
[作者:Yan, T; Tang, G; Ren, T; Shen, D; Sun, K; Liang, W; Guo, W,期刊:Cancer gene therapy, 页码:450-456 , 文章类型: Article,,卷期:2011年18-6]
- Metastatic disease is the primary cause of mortality among patients with osteogenic sarcoma (OGS). In this study, we aimed to identify the relationship of COPS3 gene expression to metastasis. Immunohistochemical staining...
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