- Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
[作者：De Palma, M; Mazzieri, R; Politi, LS; Pucci, F; Zonari, E; Sitia, G; Mazzoleni, S; Moi, D; Venneri, MA; Indraccolo, S; Falini, A; Guiclotti, LG; Galli, R; Naldini, L,期刊：Cancer Cell, 页码：299-311 , 文章类型： Article，,卷期：2008年14-4]
- The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to del...
- A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
[作者：Kolluri, SK; Zhu, XW; Zhou, X; Lin, BZ; Chen, Y; Sun, K; Tian, XF; Town, J; Cao, XH; Lin, F; Zhai, DY; Kitada, S; Luciano, F; O'Donnell, E; Cao, Y; He, F; Lin, JL; Reed, JC; Satterthwait, AC; Zhang, XK,期刊：Cancer Cell, 页码：285-298 , 文章类型： Article，,卷期：2008年14-4]
- Bcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anticancer therapeutics has not been explored. Here we report the identification of a Nur77-d...
- Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
[作者：Kotecha, N; Floress, NJ; Irish, JM; Simonds, EF; Sakai, DS; Archambeault, S; Diaz-Flores, E; Coram, M; Shannon, KM; Nolan, GP; Loh, ML,期刊：Cancer Cell, 页码：335-343 , 文章类型： Article，,卷期：2008年14-4]
- Progress in understanding the molecular pathogenesis of human myeloproliferative disorders (MPDs) has led to guidelines incorporating genetic assays with histopathology during diagnosis. Advances in flow cytometry have m...
- Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
[作者：Wang, RH; Sengupta, K; Li, CL; Kim, HS; Cao, L; Xiao, CY; Kim, SS; Xu, XL; Zheng, Y; Chilton, B; Jia, R; Zheng, ZM; Appella, E; Wang, XW; Ried, T; Deng, CX,期刊：Cancer Cell, 页码：312-323 , 文章类型： Article，,卷期：2008年14-4]
- In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function....
- Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
[作者：Bajou, K; Peng, H; Laug, WE; Maillard, C; Noel, A; Foidart, JM; Martial, JA; DeClerck, YA,期刊：Cancer Cell, 页码：324-334 , 文章类型： Article，,卷期：2008年14-4]
- Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is essential to protect e...
- Going with the flow: JAK-STAT signaling in JMML
[作者：Kalaitzidis, D; Gilliland, DG,期刊：Cancer Cell, 页码：279-280 , 文章类型： Editorial Material，,卷期：2008年14-4]
- Knowledge of the distinctive cellular and genetic traits of a cancer aids in diagnosis, prognosis, and potentially treatment. In this issue of Cancer Cell, Kotecha et al. (2008) demonstrate using a sophisticated flow cyt...
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