- A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
[作者：Wooldridge, L; Ekeruche-Makinde, J; van den Berg, HA; Skowera, A; Miles, JJ; Tan, MP; Dolton, G; Clement, M; Llewellyn-Lacey, S; Price, DA; Peakman, M; Sewell, AK,期刊：Journal of Biological Chemistry, 页码：1168-1177 , 文章类型： Article，,卷期：2012年287-2]
- The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex (MHC) molecules. Effective immunity requires that al...
- CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling
[作者：Palazuelos, J; Ortega, Z; Diaz-Alonso, J; Guzman, M; Galve-Roperh, I,期刊：Journal of Biological Chemistry, 页码：1198-1209 , 文章类型： Article，,卷期：2012年287-2]
- The endocannabinoid system is known to regulate neural progenitor (NP) cell proliferation and neurogenesis. In particular, CB2 cannabinoid receptors have been shown to promote NP proliferation. As CB2 receptors are not e...
- Activation of PDE10 and PDE11 Phosphodiesterases
[作者：Jager, R; Russwurm, C; Schwede, F; Genieser, HG; Koesling, D; Russwurm, M,期刊：Journal of Biological Chemistry, 页码：1210-1219 , 文章类型： Article，,卷期：2012年287-2]
- The most recently identified cyclic nucleotide phosphodiesterases, PDE10 and PDE11, contain a tandem of so-called GAF domains in their N-terminal regulatory regions. In PDE2 and PDE5, the GAF domains mediate cGMP stimula...
- Identification of Molecular Determinants from Moloney Leukemia Virus 10 Homolog (MOV10) Protein for Virion Packaging and Anti-HIV-1 Activity
[作者：Abudu, A; Wang, XJ; Dang, Y; Zhou, T; Xiang, SH; Zheng, YH,期刊：Journal of Biological Chemistry, 页码：1220-1228 , 文章类型： Article，,卷期：2012年287-2]
- Discovery of novel antiretroviral mechanism is essential for the design of innovative antiretroviral therapy. Recently, we and others reported that ectopic expression of Moloney leukemia virus 10 (MOV10) protein strongly...
- Jarid2 (Jumonji, AT Rich Interactive Domain 2) Regulates NOTCH1 Expression via Histone Modification in the Developing Heart
[作者：Mysliwiec, MR; Carlson, CD; Tietjen, J; Hung, H; Ansari, AZ; Lee, Y,期刊：Journal of Biological Chemistry, 页码：1235-1241 , 文章类型： Article，,卷期：2012年287-2]
- Jarid2/Jumonji, the founding member of the Jmj factor family, critically regulates various developmental processes, including cardiovascular development. The Jmj family was identified as histone demethylases, indicating ...
- Long Glucocorticoid-induced Leucine Zipper (L-GILZ) Protein Interacts with Ras Protein Pathway and Contributes to Spermatogenesis Control
[作者：Bruscoli, S; Velardi, E; Di Sante, M; Bereshchenko, O; Venanzi, A; Coppo, M; Berno, V; Mameli, MG; Colella, R; Cavaliere, A; Riccardi, C,期刊：Journal of Biological Chemistry, 页码：1242-1251 , 文章类型： Article，,卷期：2012年287-2]
- Correct function of spermatogonia is critical for the maintenance of spermatogenesis throughout life, but the cellular pathways regulating undifferentiated spermatogonia proliferation, differentiation, and survival are o...
- Origin of Initial Burst in Activity for Trichoderma reesei endo-Glucanases Hydrolyzing Insoluble Cellulose
[作者：Murphy, L; Cruys-Bagger, N; Damgaard, HD; Baumann, MJ; Olsen, SN; Borch, K; Lassen, SF; Sweeney, M; Tatsumi, H; Westh, P,期刊：Journal of Biological Chemistry, 页码：1252-1260 , 文章类型： Article，,卷期：2012年287-2]
- The kinetics of cellulose hydrolysis have longbeen described by an initial fast hydrolysis rate, tapering rapidly off, leading to a process that takes days rather than hours to complete. This behavior has been mainly att...
- Functional Blockade of the Voltage-gated Potassium Channel Kv1.3 Mediates Reversion of T Effector to Central Memory Lymphocytes through SMAD3/p21(cip1) Signaling
[作者：Hu, LN; Gocke, AR; Knapp, E; Rosenzweig, JM; Grishkan, IV; Baxi, EG; Zhang, H; Margolick, JB; Whartenby, KA; Calabresi, PA,期刊：Journal of Biological Chemistry, 页码：1261-1268 , 文章类型： Article，,卷期：2012年287-2]
- The maintenance of T cell memory is critical for the development of rapid recall responses to pathogens, but may also have the undesired side effect of clonal expansion of T effector memory (T-EM) cells in chronic autoim...
- Structural Basis for the Recognition of C20:2-alpha GalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363
[作者：Yu, ED; Girardi, E; Wang, J; Mac, TT; Yu, KOA; Van Calenbergh, S; Porcelli, SA; Zajonc, DM,期刊：Journal of Biological Chemistry, 页码：1269-1278 , 文章类型： Article，,卷期：2012年287-2]
- Natural killer T (NKT) cells express a semi-invariant V alpha 14T cell receptor (TCR) and recognize structurally diverse antigens presented by the antigen-presenting molecule CD1d that range from phosphoglycerolipids to ...
- Prothymosin-alpha Interacts with Mutant Huntingtin and Suppresses Its Cytotoxicity in Cell Culture
[作者：Dong, GF; Callegari, EA; Gloeckner, CJ; Ueffing, M; Wang, HM,期刊：Journal of Biological Chemistry, 页码：1279-1289 , 文章类型： Article，,卷期：2012年287-2]
- Huntington disease (HD), a fatal neurodegenerative disorder, is caused by a lengthening of the polyglutamine tract in the huntingtin (Htt) protein. Despite considerable effort, thus far there is no cure or treatment avai...
- Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones
[作者：Ma, LJ; Liu, Y; El-Achkar, TM; Wu, XR,期刊：Journal of Biological Chemistry, 页码：1290-1305 , 文章类型： Article，,卷期：2012年287-2]
- Correct folding of a nascent polypeptide in the lumen of the endoplasmic reticulum (ER) into a three-dimensional conformation is a crucial step in the stability, intracellular trafficking, and targeting to the final dest...
- Plasmodium falciparum Inhibitor-3 Homolog Increases Protein Phosphatase Type 1 Activity and Is Essential for Parasitic Survival
[作者：Freville, A; Landrieu, I; Garcia-Gimeno, MA; Vicogne, J; Montbarbon, M; Bertin, B; Verger, A; Kalamou, H; Sanz, P; Werkmeister, E; Pierrot, C; Khalife, J,期刊：Journal of Biological Chemistry, 页码：1306-1321 , 文章类型： Article，,卷期：2012年287-2]
- Growing evidence indicates that the protein regulators governing protein phosphatase 1 (PP1) activity have crucial functions because their deletion drastically affects cell growth and division. PP1 has been found to be e...
- Makorin Ring Zinc Finger Protein 1 (MKRN1), a Novel Poly(A)-binding Protein-interacting Protein, Stimulates Translation in Nerve Cells
[作者：Miroci, H; Schob, C; Kindler, S; Olschlager-Schutt, J; Fehr, S; Jungenitz, T; Schwarzacher, SW; Bagni, C; Mohr, E,期刊：Journal of Biological Chemistry, 页码：1322-1334 , 文章类型： Article，,卷期：2012年287-2]
- The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein complexes, plays a crucial role in the control of mRNA translation rates, stability, and subcellular targeting. In this study we identify...
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