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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formation [作者：Deng, XY; Habel, JE; Kabaleeswaran, V; Snell, EH; Wold, MS; Borgstahl, GEO,期刊：Journal of Molecular Biology, 页码：865-876 , 文章类型： Article，,卷期：2007年374-4] Replication protein A (RPA) is the ubiquitous, eukaryotic single-stranded DNA (ssDNA) binding protein and is essential for DNA replication, recombination, and repair. Here, crystal structures of the soluble RPA heterodim... Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: Crystallographic analysis of a glutathione amide reductase [作者：Van Petegem, F; De Vos, D; Savvides, S; Vergauwen, B; Van Beelumen, J,期刊：Journal of Molecular Biology, 页码：883-889 , 文章类型： Article，,卷期：2007年374-4] Glutathione reductase (GR) plays a vital role in maintaining the antioxidant levels of the cytoplasm by catalyzing the reduction of glutathione disulfide to reduced glutathione, thereby using NADPH and flavin adenine din... Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases [作者：Wehenkel, A; Bellinzoni, M; Schaeffer, F; Villarino, A; Alzari, PM,期刊：Journal of Molecular Biology, 页码：890-898 , 文章类型： Article，,卷期：2007年374-4] Phospho-Ser/Thr protein phosphatases (PPs) are dinuclear metalloenzymes classed into two large families, PPP and PPM, on the basis of sequence similarity and metal ion dependence. The archetype of the PPM family is the a... A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity [作者：Roma-Mateo, C; Rios, P; Tabernero, L; Attwood, TK; Pulido, R,期刊：Journal of Molecular Biology, 页码：899-909 , 文章类型： Article，,卷期：2007年374-4] Members of the superfamily of protein tyrosine phosphatases (PTPs) share the presence of an evolutionarily conserved PTP catalytic domain. Among them, the dual-specificity phosphatases (DSPs) constitute a diverse group o... Ultrastructural analysis of the nuclear localization sequences on influenza A ribonucleoprotein complexes [作者：Wu, WWH; Weaver, LL; Pante, N,期刊：Journal of Molecular Biology, 页码：910-916 , 文章类型： Article，,卷期：2007年374-4] The influenza A genome consists of eight single-stranded RNA molecules, each associated with an oligomeric core of the structural protein, nucleoprotein, to form a distinct viral ribonucleoprotein (vRNP) complex. vRNPs a... Pathways and intermediates of amyloid fibril formation [作者：Pellarin, R; Guarnera, E; Caflisch, A,期刊：Journal of Molecular Biology, 页码：917-924 , 文章类型： Article，,卷期：2007年374-4] The lack of understanding of amyloid fibril formation at the molecular level is a major obstacle in devising strategies to interfere with the pathologies linked to peptide or protein aggregation. In particular, little is... Sorting of early and late flagellar subunits after docking at the membrane ATPase of the type III export pathway [作者：Stafford, GP; Evans, LDB; Krumscheid, R; Dhillon, P; Fraser, GM; Hughes, C,期刊：Journal of Molecular Biology, 页码：877-882 , 文章类型： Article，,卷期：2007年374-4] The bacterial flagellum assembles in a strict order, with structural subunits delivered to the growing flagellum by a type III export pathway. Early rod-and-hook subunits are exported before completion of the hook, at wh... Transcription-coupled hypernegative supercoiling of plasmid DNA by T7 RNA polymerase in Escherichia coli topoisomerase I-deficient strains [作者：Samul, R; Leng, FF,期刊：Journal of Molecular Biology, 页码：925-935 , 文章类型： Article，,卷期：2007年374-4] Transcription by RNA polymerase can stimulate negative DNA supercoiling in Escherichia coli topA strains. This phenomenon has been explained by a "twin-supercoiled-domain" model of transcription in which positive DNA sup... unc-94 encodes a tropomodulin in Caenorhabditis elegans [作者：Stevenson, TO; Mercer, KB; Cox, EA; Szewczyk, NJ; Conley, CA; Hardin, JD; Benian, GM,期刊：Journal of Molecular Biology, 页码：936-950 , 文章类型： Article，,卷期：2007年374-4] unc-94 is one of about 40 genes in Caenorhabditis elegans that, when mutant, displays an abnormal muscle phenotype. Two mutant alleles of unc-94, su177 and sf20, show reduced motility and brood size and disorganization o... Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activity [作者：Madan, V; Sanchez-Martinez, S; Vedovato, N; Rispoli, G; Carrasco, L; Nieva, JL,期刊：Journal of Molecular Biology, 页码：951-964 , 文章类型： Article，,卷期：2007年374-4] Picornavirus 2B, a non-structural protein required for effective viral replication, has been implicated in cell membrane permeabilization during the late phases of infection. Here, we have approached the molecular mechan... Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants [作者：Kozisek, M; Bray, J; Rezacova, P; Saskova, K; Brynda, J; Pokorna, J; Mammano, F; Rulisek, L; Konvalinka, J,期刊：Journal of Molecular Biology, 页码：1005-1016 , 文章类型： Article，,卷期：2007年374-4] Human immunodeficiency virus (HIV) encodes an aspartic protease (PR) that cleaves viral polyproteins into mature proteins, thus leading to the formation of infectious particles. Protease inhibitors (PIs) are successful v... Crystal structures of the luciferase and green fluorescent protein from Renilla reniformis [作者：Loening, AM; Fenn, TD; Gambhir, SS,期刊：Journal of Molecular Biology, 页码：1017-1028 , 文章类型： Article，,卷期：2007年374-4] Due to its ability to emit light, the luciferase from Renilla reniformis (RLuc) is widely employed in molecular biology as a reporter gene in cell culture experiments and small animal imaging. To accomplish this biolumin... Impact of DNA hairpin folding energetics on antibody-ssDNA association [作者：Ou, ZH; Bottoms, CA; Henzl, MT; Tanner, JJ,期刊：Journal of Molecular Biology, 页码：1029-1040 , 文章类型： Article，,卷期：2007年374-4] Deposition of anti-DNA antibodies in the kidney contributes to the pathogenesis of the autoimmune disease, systemic lupus erythematosus. Antibodies that bind to hairpin-forming DNA ligands may be particularly prone to de... Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli [作者：Savchenko, A; Proudfoot, M; Skarina, T; Singer, A; Litvinova, O; Sanishvili, R; Brown, G; Chirgadze, N; Yakunin, AF,期刊：Journal of Molecular Biology, 页码：1091-1103 , 文章类型： Article，,卷期：2007年374-4] Inosine triphosphate pyrophosphatases, which are ubiquitous house-cleaning enzymes, hydrolyze noncanonical nucleoside triphosphates (inosine triphosphate (ITP) and xanthosine triphosphate (XTP)) and prevent the incorpora... The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG [作者：Wang, YC; Maegawa, S; Akiyama, Y; Ha, Y,期刊：Journal of Molecular Biology, 页码：1104-1113 , 文章类型： Article，,卷期：2007年374-4] Intramembrane proteases are important enzymes in biology. The recently solved crystal structures of rhomboid protease GlpG have provided useful insights into the mechanism of these membrane proteins. Besides revealing an... A large conformational change couples the ATP binding site of SecA to the SecY protein channel [作者：Robson, A; Booth, AEG; Gold, VAM; Clarke, AR; Collinson, I,期刊：Journal of Molecular Biology, 页码：965-976 , 文章类型： Article，,卷期：2007年374-4] In bacteria, the SecYEG protein translocation complex employs the cytosolic ATPase SecA to couple the energy of ATP binding and hydrolysis to the mechanical force required to push polypeptides through the membrane. The m...