- Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma
[作者:Su, Y; Wagner, ER; Luo, Q; Huang, J; Chen, L; He, BC; Zuo, GW; Shi, Q; Zhang, BQ; Zhu, G; Bi, Y; Luo, J; Luo, X; Kim, SH; Shen, J; Rastegar, F; Huang, E; Gao, Y; Gao, JL; Yang, K; Wietholt, C; Li, M; Qin, J; Haydon, RC; He, TC; Luu, HH,期刊:Oncogene, 页码:3907-3917 , 文章类型: Article,,卷期:2011年30-37]
- Osteosarcoma (OS) is the most common primary malignancy of bone. There is a critical need to identify the events that lead to the poorly understood mechanism of OS development and metastasis. The goal of this investigati...
- BH3 mimetics activate multiple pro-autophagic pathways
[作者:Malik, SA; Orhon, I; Morselli, E; Criollo, A; Shen, S; Marino, G; BenYounes, A; Benit, P; Rustin, P; Maiuri, MC; Kroemer, G,期刊:Oncogene, 页码:3918-3929 , 文章类型: Article,,卷期:2011年30-37]
- The BH3 mimetic ABT737 induces autophagy by competitively disrupting the inhibitory interaction between the BH3 domain of Beclin 1 and the anti-apoptotic proteins Bcl-2 and Bcl-XL, thereby stimulating the Beclin 1-depend...
- Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription
[作者:Zhang, Q; Zhong, Q; Evans, AG; Levy, D; Zhong, S,期刊:Oncogene, 页码:3943-3952 , 文章类型: Article,,卷期:2011年30-37]
- Deregulation of RNA polymerase III (Pol III) transcription enhances cellular tRNAs and 5S rRNA production, leading to an increase in translational capacity to promote cell proliferation, transformation and tumor formatio...
- SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
[作者:Lind, GE; Raiborg, C; Danielsen, SA; Rognum, TO; Thiis-Evensen, E; Hoff, G; Nesbakken, A; Stenmark, H; Lothe, RA,期刊:Oncogene, 页码:3967-3978 , 文章类型: Article,,卷期:2011年30-37]
- Colorectal cancer is a common disease with high mortality. Suitable biomarkers for detection of tumors at an early curable stage would significantly improve patient survival. Here, we show that the SPG20 (spastic paraple...
- E2F1 suppresses Wnt/beta-catenin activity through transactivation of beta-catenin interacting protein ICAT
[作者:Wu, Z; Zheng, S; Li, Z; Tan, J; Yu, Q,期刊:Oncogene, 页码:3979-3984 , 文章类型: Article,,卷期:2011年30-37]
- Deregulation of the pRb/E2F or Wnt/beta-catenin pathway occurs frequently in human cancers, which is often associated with inappropriate cell proliferation. Although the oncogenic roles of pRb/E2F1 and Wnt/beta-catenin p...
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