- Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes
[作者：MAURYA RANJANI; SONI AWAKASH; ANAND DEVIREDDY; RAVI MAKTHALA; RAJU KANUMURI S R; TANEJA ISHA; NAIKADE NIRAJ K; PURI S K; WAHAJUDDIN; KANOJIYA SANJEEV; YADAV PREM P,期刊：ACS Medicinal Chemistry Letters, 页码：165-169 , 文章类型： Article，,卷期：2013年4-2]
- Novel 3,3-spiroanellated 5-aryl, 6-arylvinyl-substituted 1,2,4-trioxanes 19-34 have been synthesized and appraised for their antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice b...
- Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents
[作者：CHAN SAU HING; CHUI CHUNG HIN; CHAN SHUN WAN; KOK STANTON HON LUN; CHAN DESSY; TSOI MIRIAM YUEN TUNG; LEUNG POLLY HANG MEI; LAM ALFRED KING YIN; CHAN ALBERT SUN CHI; LAM KIM HUNG; TANG JOHNNY CHEUK ON,期刊：ACS Medicinal Chemistry Letters, 页码：170-174 , 文章类型： Article，,卷期：2013年4-2]
- This letter describes the preparation of quinoline derivatives and their cytotoxic potentials toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2-quinolinecarbaldehyde (3) showed the best in vitr...
- Improving the Affinity of SL0101 for RSK Using Structure-Based Design
[作者：MROZOWSKI ROMAN M; VEMULA RAJENDER; WU BULAN; ZHANG QI; SCHROEDER BENJAMIN R; HILINSKI MICHAEL K; CLARK DAVID E; HECHT SIDNEY M; ODOHERTY GEORGE A; LANNIGAN DEBORAH A,期刊：ACS Medicinal Chemistry Letters, 页码：175-179 , 文章类型： Article，,卷期：2013年4-2]
- Enhanced activity of the Ser/Thr protein kinase, RSK, is associated with transformation and metastasis, which suggests that RSK is an attractive drug target. The natural product SL0101 (kaempferol 3-O-(3 '',4 ''-di-O-ace...
- The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein-Protein Interactions
[作者：TOURE B BARRY; MILLERMOSLIN KAREN; YUSUFF NAEEM; PEREZ LAWRENCE; DORE MICHAEL; JOUD CAROL; MICHAEL WALTER; DIPIETRO LUCIAN; VAN DER PLAS SIMON; MCEWAN MICHAEL; LENOIR FRANCOIS; HOE MADELENE; KARKI RAJESH; SPRINGER CLAYTON; SULLIVAN JOHN; LEVINE KYMBERLY; FIORILLA CATHERINE; XIE XIAOLING; KULATHILA RAVIRAJ; HERLIHY KARA; PORTER DALE; VISSER MICHAEL,期刊：ACS Medicinal Chemistry Letters, 页码：186-190 , 文章类型： Article，,卷期：2013年4-2]
- Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a se...
- Metal Impurities Cause False Positives in High-Throughput Screening Campaigns
[作者：HERMANN JOHANNES C; CHEN YINGSI; WARTCHOW CHARLES; MENKE JOHN; GAO LIN; GLEASON SHELLEY K; HAYNES NANCYELLEN; SCOTT NATHAN; PETERSEN ANN; GABRIEL STEPHEN; BINH VU; GEORGE KELLY M; NARAYANAN ARJUN; LI SHIRLEY H; QIAN HONG; BEATINI NANDA; NIU LINGHAO; GAN QINGFEN,期刊：ACS Medicinal Chemistry Letters, 页码：197-200 , 文章类型： Article，,卷期：2013年4-2]
- Organic impurities in compound libraries are known to often cause false-positive signals in screening campaigns for new leads, but organic impurities do not fully account for all false-positive results. We discovered ino...
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