- Differential functions of phospholipid binding and palmitoylation of tumour suppressor EWI2/PGRL
[作者:He, B; Zhang, YHH; Richardson, MM; Zhang, JS; Rubinstein, E; Zhang, XA,期刊:Biochemical Journal, 页码:399-411 , 文章类型: Article,,卷期:2011年437-Part 3]
- The tumour suppressor EWI2 associates with tetraspanins and regulates tumour cell movement and proliferation. The short cytoplasmic domain of EWI2 is positively charged; five out of the ten residues of this domain are ba...
- The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development
[作者:Norville, IH; O'Shea, K; Sarkar-Tyson, M; Zheng, SX; Titball, RW; Varani, G; Harmer, NJ,期刊:Biochemical Journal, 页码:413-422 , 文章类型: Article,,卷期:2011年437-Part 3]
- Mips (macrophage infectivity potentiators) are a subset of immunophilins associated with virulence in a range of microorganisms. These proteins possess peptidylprolyl isomerase activity and are inhibited by drugs includi...
- Crystal structure of a novel type of odorant-binding protein from Anopheles gambiae, belonging to the C-plus class
[作者:Lagarde, A; Spinelli, S; Qiao, HL; Tegoni, M; Pelosi, P; Cambillau, C,期刊:Biochemical Journal, 页码:423-430 , 文章类型: Article,,卷期:2011年437-Part 3]
- Agam (Anopheles gambiae) relies on its olfactory system to target human prey, leading eventually to the injection of Plasmodium falciparum, the malaria vector. OBPs (odorant-binding proteins) are the first line of protei...
- Human and mouse granzyme M display divergent and species-specific substrate specificities
[作者:de Poot, SAH; Westgeest, M; Hostetter, DR; Van Damme, P; Plasman, K; Demeyer, K; Broekhuizen, R; Gevaert, K; Craik, CS; Bovenschen, N,期刊:Biochemical Journal, 页码:431-442 , 文章类型: Article,,卷期:2011年437-Part 3]
- Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) display extensive sequence homology, the substra...
- Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)(2)] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38(MAPK)/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
[作者:Filomeni, G; Cardaci, S; Ferreira, AMD; Rotilio, G; Ciriolo, MR,期刊:Biochemical Journal, 页码:443-453 , 文章类型: Article,,卷期:2011年437-Part 3]
- We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N']copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in ...
- GATA-4 transcription factor regulates hepatic hepcidin expression
[作者:Island, ML; Fatih, N; Leroyer, P; Brissot, P; Loreal, O,期刊:Biochemical Journal, 页码:477-482 , 文章类型: Article,,卷期:2011年437-Part 3]
- Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regulates iron release from macropha...
- Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts
[作者:Meszaros, P; Klappe, K; Hummel, I; Hoekstra, D; Kok, JW,期刊:Biochemical Journal, 页码:483-491 , 文章类型: Article,,卷期:2011年437-Part 3]
- MRP1 (multidrug-resistance-related protein 1)/ABCC1 (ATP-binding cassette transporter C1) has been localized in cholesterol-enriched lipid rafts, which suggests a role for these lipid rafts and/or cholesterol in MRP1 fun...
- NMR spectroscopy of 14-3-3 zeta reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3 zeta
[作者:Williams, DM; Ecroyd, H; Goodwin, KL; Dai, HQ; Fu, HA; Woodcock, JM; Zhang, LX; Carver, JA,期刊:Biochemical Journal, 页码:493-503 , 文章类型: Article,,卷期:2011年437-Part 3]
- Intracellular 14-3-3 proteins bind to many proteins, via a specific phosphoserine motif, regulating diverse cellular tasks including cell signalling and disease progression. The 14-3-3 zeta isoform is a molecular chapero...
- Evidence that ACN1 (acetate non-utilizing 1) prevents carbon leakage from peroxisomes during lipid mobilization in Arabidopsis seedlings
[作者:Allen, E; Moing, A; Wattis, JAD; Larson, T; Maucourt, M; Graham, IA; Rolin, D; Hooks, MA,期刊:Biochemical Journal, 页码:505-513 , 文章类型: Article,,卷期:2011年437-Part 3]
- ACN1 (acetate non-utilizing 1) is a short-chain acyl-CoA synthetase which recycles free acetate to acetyl-CoA in peroxisomes of Arabidopsis. Pulse-chase [2-C-13]acetate feeding of the mutant acn1-2 revealed that acetate ...
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