- Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
[作者:Pappalardi, MB; McNulty, DE; Martin, JD; Fisher, KE; Jiang, Y; Burns, MC; Zhao, HZ; Ho, T; Sweitzer, S; Schwartz, B; Annan, RS; Copeland, RA; Tummino, PJ; Luo, LS,期刊:Biochemical Journal, 页码:363-369 , 文章类型: Article,,卷期:2011年436-Part 2]
- The HIF (hypoxia-inducible factor) plays a central regulatory role in oxygen homoeostasis. HIF proteins are regulated by three Fe(II)- and alpha-KG (alpha-ketoglutarate)-dependent prolyl hydroxylase enzymes [PHD (prolyl ...
- A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
[作者:Sokolowska, I; Walchli, S; Wegrzyn, G; Sandvig, K; Slominska-Wojewodzka, M,期刊:Biochemical Journal, 页码:371-385 , 文章类型: Article,,卷期:2011年436-Part 2]
- Ricin is a potent plant cytotoxin composed of an A-chain [RTA (ricin A-chain)] connected by a disulfide bond to a cell binding lectin B-chain [RTB (ricin B-chain)]. After endocytic uptake, the toxin is transported retrog...
- The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response
[作者:Maruyama, A; Nishikawa, K; Kawatani, Y; Mimura, J; Hosoya, T; Harada, N; Yamamato, M; Itoh, K,期刊:Biochemical Journal, 页码:387-397 , 文章类型: Article,,卷期:2011年436-Part 2]
- The transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) co-ordinately regulates ARE (antioxidant-response element)-mediated induction of cytoprotective genes in response to electrophiles and oxidative...
- Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing
[作者:Ikeda, T; Sun, L; Tsuruoka, N; Ishigaki, Y; Yoshitomi, Y; Yoshitake, Y; Yonekura, H,期刊:Biochemical Journal, 页码:399-407 , 文章类型: Article,,卷期:2011年436-Part 2]
- sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates sFlt-1 expression in HMVECs (huma...
- Movement of hCIC-1 C-termini during common gating and limits on their cytoplasmic location
[作者:Ma, LL; Rychkov, GY; Bykova, EA; Zheng, J; Bretag, AH,期刊:Biochemical Journal, 页码:415-428 , 文章类型: Article,,卷期:2011年436-Part 2]
- Functionally, the dimeric human skeletal muscle chloride channel hClC-1 is characterized by two distinctive gating processes, fast (protopore) gating and slow (common) gating. Of these, common gating is poorly understood...
- Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin
[作者:Chen, Z; Zhao, TJ; Li, J; Gao, YS; Meng, FG; Yan, YB; Zhou, HM,期刊:Biochemical Journal, 页码:437-445 , 文章类型: Article,,卷期:2011年436-Part 2]
- Muscle contraction requires high energy fluxes, which are supplied by MM-CK (muscle-type creatine kinase) which couples to the myofibril. However, little is known about the detailed molecular mechanisms of how MM-CK part...
- Biochemical correlation of activity of the alpha-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease
[作者:Voglmeir, J; Kaloo, S; Laurent, N; Meloni, MM; Bohlmann, L; Wilson, IBH; Flitsch, SL,期刊:Biochemical Journal, 页码:447-455 , 文章类型: Article,,卷期:2011年436-Part 2]
- Congenital muscular dystrophies have a broad spectrum of genotypes and phenotypes and there is a need for a better biochemical understanding of this group of diseases in order to aid diagnosis and treatment. Several muta...
- Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor kappa B (NF-kappa B) signalling pathway
[作者:Song, ZB; Bao, YL; Zhang, Y; Mi, XG; Wu, P; Wu, Y; Yu, CL; Sun, Y; Zheng, LH; Huang, YX; Liu, BA; Li, YX,期刊:Biochemical Journal, 页码:457-467 , 文章类型: Article,,卷期:2011年436-Part 2]
- TSP50 (testes-specific protease 50) is a testis-specific expression protein, which is expressed abnormally at high levels in breast cancer tissues. This makes it an attractive molecular marker and a potential target for ...
- Reversible membrane reorganizations during photosynthesis in vivo: revealed by small-angle neutron scattering
[作者:Nagy, G; Posselt, D; Kovacs, L; Holm, JK; Szabo, M; Ughy, B; Rosta, L; Peters, J; Timmins, P; Garab, G,期刊:Biochemical Journal, 页码:225-230 , 文章类型: Article,,卷期:2011年436-Part 2]
- In the present study, we determined characteristic repeat distances of the photosynthetic membranes in living cyanobacterial and eukaryotic algal cells, and in intact thylakoid membranes isolated from higher plants with ...
- InsP(3) receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences
[作者:Lur, G; Sherwood, MW; Ebisui, E; Haynes, L; Feske, S; Sutton, R; Burgoyne, RD; Mikoshiba, K; Petersen, OH; Tepikin, AV,期刊:Biochemical Journal, 页码:231-239 , 文章类型: Article,,卷期:2011年436-Part 2]
- Orai1 proteins have been recently identified as subunits of SOCE (store-operated Ca2+ entry) channels. In primary isolated PACs (pancreatic acinar cells), Orai 1 showed remarkable co-localization and co-immunoprecipitati...
- RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation
[作者:Kim, JH; Kim, K; Youn, BU; Jin, HM; Kim, JY; Moon, JB; Ko, A; Seo, SB; Lee, KY; Kim, N,期刊:Biochemical Journal, 页码:253-262 , 文章类型: Article,,卷期:2011年436-Part 2]
- NFATc1 (nuclear factor of activated T-cells c1), a key transcription factor, plays a role in regulating expression of osteoclast-specific downstream target genes such as TRAP (tartrate-resistant acid phosphatase) and OSC...
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